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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1949 1
1950 2
1951 2
1954 1
1957 1
1959 1
1960 1
1962 3
1963 1
1964 1
1989 18
1990 42
1991 79
1992 119
1993 150
1994 185
1995 232
1996 289
1997 328
1998 364
1999 410
2000 412
2001 418
2002 373
2003 373
2004 394
2005 366
2006 341
2007 349
2008 323
2009 269
2010 303
2011 299
2012 279
2013 294
2014 273
2015 254
2016 178
2017 151
2018 108
2019 50
2020 1
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7,573 results
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Page 1
Ki-67: more than a proliferation marker
Sun X and Kaufman PD. Chromosoma 2018 - Review. PMID 29322240 Free PMC article.
Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular functions of this large protein have become better understood. ...
Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular …
NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination
Ruscetti M, et al. Science 2018. PMID 30573629 Free PMC article.
We show that mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 4/6 inhibitors act in combination to suppress the proliferation of KRAS-mutant lung cancer cells while simultaneously provoking a natural killer (NK) cell surveillance program leading to tumor cell death. The drug combination, but neither agent alone, promotes retinoblastoma (RB) protein-mediated cellular senescence and activation of the immunomodulatory senescence-associated secretory phenotype (SASP). ...
We show that mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 4/6 inhibitors act in combination to suppress the pr …
Merkel Cell Carcinoma
Pulitzer M. Surg Pathol Clin 2017 - Review. PMID 28477888 Free PMC article.
Merkel cell carcinoma (MCC) encompasses neuroendocrine carcinomas primary to skin and occurs most commonly in association with clonally integrated Merkel cell polyomavirus with related retinoblastoma protein sequestration or in association with UV radiation-induced alterations involving the TP53 gene and mutations, heterozygous deletion, and hypermethylation of the Retinoblastoma gene. ...
Merkel cell carcinoma (MCC) encompasses neuroendocrine carcinomas primary to skin and occurs most commonly in association with clonally inte …
Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix.
Topacio BR, et al. Mol Cell 2019. PMID 30982746 Free PMC article.
A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, which inhibits cell-cycle progression until its inactivation by phosphorylation. ...Our work conclusively demonstrates that the cyclin D-Rb interaction drives cell division and expands the diversity of known cyclin-based protein docking mechanisms....
A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, which inhibits cell-cycle progression until its inact …
A parapoxviral virion protein targets the retinoblastoma protein to inhibit NF-κB signaling.
Nagendraprabhu P, et al. PLoS Pathog 2017. PMID 29244863 Free PMC article.
A C-terminal LxCxE motif in ORFV119 enabled the protein to interact with the retinoblastoma protein (pRb) a multifunctional protein best known for its tumor suppressor activity. ...ORFV119 represents the first poxviral protein to interfere with NF-κB signaling through interaction with pRb....
A C-terminal LxCxE motif in ORFV119 enabled the protein to interact with the retinoblastoma protein (pRb) a multifuncti …
MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition.
Rand TA, et al. Cell Rep 2018. PMID 29641997 Free article.
These changes inactivated retinoblastoma protein (RB) and reactivated proliferation. The RB-regulated proliferation pause does not occur in immortalized fibroblasts, leading to high reprogramming efficiency even without exogenous MYC....
These changes inactivated retinoblastoma protein (RB) and reactivated proliferation. The RB-regulated proliferation pause does …
Targeting retinoblastoma protein phosphorylation in combination with EGFR inhibition in pancreatic cancer cells.
Thomas NA, et al. Int J Oncol 2019. PMID 30535494 Free PMC article.
The retinoblastoma (Rb) tumor suppressor protein is an additional target in pancreatic cancer, due to its documented inactivation in PDAC. ...
The retinoblastoma (Rb) tumor suppressor protein is an additional target in pancreatic cancer, due to its documented inactivat …
Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression
Jin X, et al. Mol Cell 2019. PMID 30527665 Free article.
The retinoblastoma protein RB is a tumor suppressor known to regulate the cell cycle, DNA damage response, and differentiation. Here, we demonstrate that RB interacts with nuclear factor κB (NF-κB) protein p65 and that their interaction is primarily dependent on CDK4/6-mediated serine-249/threonine-252 (S249/T252) phosphorylation of RB. ...
The retinoblastoma protein RB is a tumor suppressor known to regulate the cell cycle, DNA damage response, and differentiation …
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