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Page 1
Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage.
Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vázquez-Martínez L, Girbl T, Poston RN, Golding M, Saleeb RS, Thiriot A, von Andrian UH, Duchene J, Voisin MB, Bishop CL, Voehringer D, Roers A, Rot A, Lämmermann T, Nourshargh S. Barkaway A, et al. Among authors: rolas l. Immunity. 2021 Jul 13;54(7):1494-1510.e7. doi: 10.1016/j.immuni.2021.04.025. Epub 2021 May 24. Immunity. 2021. PMID: 34033752 Free PMC article.
Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation.
Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS, Gonzalez-Nuñez M, Austin-Williams SN, Cooper D, Vázquez-Martínez L, Fu T, De Rossi G, Golding M, Voisin MB, Boulanger CM, Kubota Y, Muller WA, Tooze SA, Nightingale TD, Collinson L, Perretti M, Aksoy E, Nourshargh S. Reglero-Real N, et al. Among authors: rolas l. Immunity. 2021 Sep 14;54(9):1989-2004.e9. doi: 10.1016/j.immuni.2021.07.012. Epub 2021 Aug 6. Immunity. 2021. PMID: 34363750 Free PMC article.
Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis.
Girbl T, Lenn T, Perez L, Rolas L, Barkaway A, Thiriot A, Del Fresno C, Lynam E, Hub E, Thelen M, Graham G, Alon R, Sancho D, von Andrian UH, Voisin MB, Rot A, Nourshargh S. Girbl T, et al. Among authors: rolas l. Immunity. 2018 Dec 18;49(6):1062-1076.e6. doi: 10.1016/j.immuni.2018.09.018. Epub 2018 Nov 13. Immunity. 2018. PMID: 30446388 Free PMC article.
Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome.
Santiago-Fernández O, Osorio FG, Quesada V, Rodríguez F, Basso S, Maeso D, Rolas L, Barkaway A, Nourshargh S, Folgueras AR, Freije JMP, López-Otín C. Santiago-Fernández O, et al. Among authors: rolas l. Nat Med. 2019 Mar;25(3):423-426. doi: 10.1038/s41591-018-0338-6. Epub 2019 Feb 18. Nat Med. 2019. PMID: 30778239 Free PMC article.
Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues.
Rolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L, Golding M, Blacksell IA, Giblin MJ, Jaworska E, Bishop CL, Voisin MB, Gaston-Massuet C, Fossati-Jimack L, Pitzalis C, Cooper D, Nightingale TD, Lopez-Otin C, Lewis MJ, Nourshargh S. Rolas L, et al. EMBO Rep. 2024 Sep;25(9):3842-3869. doi: 10.1038/s44319-024-00182-x. Epub 2024 Jun 25. EMBO Rep. 2024. PMID: 38918502 Free PMC article.
Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells.
Benedicto I, Carmona RM, Barettino A, Espinós-Estévez C, Gonzalo P, Nevado RM, de la Fuente-Pérez M, Andrés-Manzano MJ, González-Gómez C, Rolas L, Dorado B, Nourshargh S, Hamczyk MR, Andrés V. Benedicto I, et al. Among authors: rolas l. Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2400752121. doi: 10.1073/pnas.2400752121. Epub 2024 Apr 22. Proc Natl Acad Sci U S A. 2024. PMID: 38648484 Free PMC article.
Cardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome.
Sánchez-López A, Espinós-Estévez C, González-Gómez C, Gonzalo P, Andrés-Manzano MJ, Fanjul V, Riquelme-Borja R, Hamczyk MR, Macías Á, Del Campo L, Camafeita E, Vázquez J, Barkaway A, Rolas L, Nourshargh S, Dorado B, Benedicto I, Andrés V. Sánchez-López A, et al. Among authors: rolas l. Circulation. 2021 Nov 30;144(22):1777-1794. doi: 10.1161/CIRCULATIONAHA.121.055313. Epub 2021 Oct 25. Circulation. 2021. PMID: 34694158 Free PMC article.
Leukocyte Trafficking: Time to Take Time Seriously.
Reglero-Real N, Rolas L, Nourshargh S. Reglero-Real N, et al. Among authors: rolas l. Immunity. 2019 Feb 19;50(2):273-275. doi: 10.1016/j.immuni.2019.01.013. Immunity. 2019. PMID: 30784571 Free article.
17 results