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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
1995 3
1997 8
1998 52
1999 52
2000 97
2001 110
2002 132
2003 154
2004 164
2005 105
2006 13
2007 14
2008 25
2009 31
2010 37
2011 59
2012 50
2013 66
2014 89
2015 107
2016 115
2017 120
2018 121
2019 49
2020 0
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1,614 results
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Page 1
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.
Minakaki G, et al. Autophagy 2018. PMID 29198173 Free PMC article.
The autophagy-lysosome pathway (ALP) regulates intracellular homeostasis of the cytosolic protein SNCA/alpha-synuclein and is impaired in synucleinopathies, including Parkinson disease and dementia with Lewy bodies (DLB). ...Thus, macroautophagy/autophagy may regulate EV protein composition and consequently progression in synucleinopathies....
The autophagy-lysosome pathway (ALP) regulates intracellular homeostasis of the cytosolic protein SNCA/alpha-synuclein and is …
NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein
Goedert M. Science 2015 - Review. PMID 26250687
Overexpression of these mutant proteins can give rise to disease-associated phenotypes. Protein assembly begins in specific regions of the brain during the process of Alzheimer's and Parkinson's diseases, from where it spreads to other areas....
Overexpression of these mutant proteins can give rise to disease-associated phenotypes. Protein assembly begins in specific re …
Alpha-synuclein and the prion hypothesis in Parkinson's disease
Melki R. Rev Neurol (Paris) 2018 - Review. PMID 30201422
Protein intracellular inclusions within the central nervous system are hallmarks of several progressive neurodegenerative disorders in man. ...Until recently, the vicious circle consisting of spread, seeded assembly and accumulation over time within the central nervous system of misfolded proteins aggregates was thought to be restricted to the prion protein PrP. ...
Protein intracellular inclusions within the central nervous system are hallmarks of several progressive neurodegenerative disorders i
Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.
Kantor B, et al. Mol Ther 2018. PMID 30266652 Free PMC article.
We ought to develop new therapeutic strategies targeting the regulation of SNCA expression. DNA methylation at SNCA intron 1 regulates SNCA transcription, and PD brains showed differential methylation levels compared to controls. ...Applying the system to human induced pluripotent stem cell (hiPSC)-derived dopaminergic neurons from a PD patient with the SNCA triplication resulted in fine downregulation of SNCA mRNA and protein mediated by targeted DNA methylation at intron 1. ...
We ought to develop new therapeutic strategies targeting the regulation of SNCA expression. DNA methylation at SNCA intron 1 r …
Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons.
Heman-Ackah SM, et al. Hum Mol Genet 2017. PMID 28973645 Free PMC article.
We used the double-nicking CRISPR/Cas9 system to conduct site-specific mutagenesis of SNCA in these cells, generating an isogenic iPSC line with normalized SNCA gene dosage. Comparative gene expression analysis of neuronal derivatives from these iPSCs revealed an ER stress phenotype, marked by induction of the IRE1α/XBP1 axis of the unfolded protein response (UPR) and culminating in terminal UPR activation. ...
We used the double-nicking CRISPR/Cas9 system to conduct site-specific mutagenesis of SNCA in these cells, generating an isogenic iPS …
Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature
Schneider SA and Alcalay RN. Mov Disord 2017 - Review. PMID 29124790 Free PMC article.
We review the literature of genetic PD autopsies from cases with molecularly confirmed PD or parkinsonism and summarize main findings on SNCA (n = 25), Parkin (n = 20, 17 bi-allelic and 3 heterozygotes), PINK1 (n = 5, 1 bi-allelic and 4 heterozygotes), DJ-1 (n = 1), LRRK2 (n = 55), GBA (n = 10 Gaucher disease patients with parkinsonism), DNAJC13, GCH1, ATP13A2, PLA2G6 (n = 8 patients, 2 with PD), MPAN (n = 2), FBXO7, RAB39B, and ATXN2 (SCA2), as well as on 22q deletion syndrome (n = 3). ...Interventions that reduce alpha-synuclein load may be more justified in SNCA-PD or GBA-PD than in other genetic forms of PD. ...
We review the literature of genetic PD autopsies from cases with molecularly confirmed PD or parkinsonism and summarize main findings on …
Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.
Poehler AM, et al. Autophagy 2014. PMID 25484190 Free PMC article.
In summary, our study revealed a novel role of the ALP by linking protein degradation to nonclassical secretion for toxic SNCA species. ...These findings suggest that the major toxic role of SNCA is related to its extracellular species and further supports a protective role of intracellular SNCA aggregation....
In summary, our study revealed a novel role of the ALP by linking protein degradation to nonclassical secretion for toxic SNCA
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