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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 2
1995 8
1996 15
1997 8
1998 12
1999 12
2000 13
2001 27
2002 27
2003 22
2004 38
2005 40
2006 35
2007 55
2008 65
2009 42
2010 44
2011 58
2012 71
2013 77
2014 76
2015 87
2016 99
2017 95
2018 90
2019 39
2020 1
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1,032 results
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Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9.
Croft B, et al. Nat Commun 2018. PMID 30552336 Free PMC article.
All three enhancers showed synergistic activity and together drive SOX9 in the testis. This is the first study to identify SOX9 enhancers that, when duplicated or deleted, result in 46,XX or 46,XY sex reversal, respectively. These enhancers provide a hitherto missing link by which SRY activates SOX9 in humans, and establish SOX9 enhancer mutations as a significant cause of DSD....
All three enhancers showed synergistic activity and together drive SOX9 in the testis. This is the first study to identify SOX9
Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas
Liu Y, et al. Cancer Cell 2018. PMID 29622466 Free PMC article.
We identified a group of tumors in the colon and rectum lacking hypermutation and aneuploidy termed genome stable and enriched in DNA hypermethylation and mutations in KRAS, SOX9, and PCBP1....
We identified a group of tumors in the colon and rectum lacking hypermutation and aneuploidy termed genome stable and enriched in DNA hyperm …
A Sox2-Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells.
Domenici G, et al. Oncogene 2019. PMID 30622340 Free PMC article.
Here, we show that Sox2 increases and estrogen reduces the expression of the transcription factor Sox9. Gain and loss of function assays indicate that Sox9 is implicated in the maintenance of human breast luminal progenitor cells. CRISPR/Cas knockout of Sox9 reduces growth of tamoxifen-resistant breast tumours in vivo. Mechanistically, Sox9 acts downstream of Sox2 to control luminal progenitor cell content and is required for expression of the cancer stem cell marker ALDH1A3 and Wnt signalling activity. ...
Here, we show that Sox2 increases and estrogen reduces the expression of the transcription factor Sox9. Gain and loss of function ass …
SOX9 and the many facets of its regulation in the chondrocyte lineage.
Lefebvre V and Dvir-Ginzberg M. Connect Tissue Res 2017 - Review. PMID 27128146 Free PMC article.
Since heterozygous mutations within and around SOX9 were shown to cause the severe skeletal malformation syndrome called campomelic dysplasia, researchers around the world have worked assiduously to decipher the many facets of SOX9 actions and regulation in chondrogenesis. The more we learn, the more we realize the complexity of the molecular networks in which SOX9 fulfills its functions and is regulated at the levels of its gene, RNA, and protein, and the more we measure the many gaps remaining in knowledge. ...
Since heterozygous mutations within and around SOX9 were shown to cause the severe skeletal malformation syndrome called campomelic d …
Rapid and efficient induction of functional astrocytes from human pluripotent stem cells.
Canals I, et al. Nat Methods 2018. PMID 30127505
The derivation of astrocytes from human pluripotent stem cells is currently slow and inefficient. We demonstrate that overexpression of the transcription factors SOX9 and NFIB in human pluripotent stem cells rapidly and efficiently yields homogeneous populations of induced astrocytes. ...Our method provides new possibilities for the study of human astrocytes in health and disease....
The derivation of astrocytes from human pluripotent stem cells is currently slow and inefficient. We demonstrate that overexpression …
SOX9 regulated proliferation and apoptosis of human lung carcinoma cells by the Wnt/β-catenin signaling pathway.
Guo YZ, et al. Eur Rev Med Pharmacol Sci 2018. PMID 30070325 Free article.
In the present study, the effects of SOX9 on proliferation and apoptosis of human lung carcinoma cells and its mechanisms were investigated. ...RESULTS: Results showed that SOX9 expression was elevated in human lung carcinoma cells. Knocking down cellular SOX9 by short hairpin RNA (shRNA) decreased cell proliferation while promoted apoptosis of A549 cells. ...
In the present study, the effects of SOX9 on proliferation and apoptosis of human lung carcinoma cells and its mechanisms were …
Expression of Reg IV and SOX9 and their correlation in human gastric cancer.
Zhang N, et al. BMC Cancer 2018. PMID 29587675 Free PMC article.
Reg IV expression vectors and a siRNA of Reg IV and SOX9 were transfected into human gastric cancer cells and the protein and mRNA levels of Reg IV and SOX9 were investigated by western blot and real-time PCR. ...SOX9 protein expression also had no significant correlations with age, clinical stage, tumor invasion depth or lymph node metastasis. ...
Reg IV expression vectors and a siRNA of Reg IV and SOX9 were transfected into human gastric cancer cells and the protein
TGF-β-mediated upregulation of Sox9 in fibroblast promotes renal fibrosis.
Li H, et al. Biochim Biophys Acta Mol Basis Dis 2018. PMID 29158184 Free article.
Sox9 exhibits diverse roles in regulating the production of extracellular matrix proteins. Here we found that Sox9 was induced by TGF-β in the kidney fibroblast and acted as an important downstream mediator of TGF-β signaling in promoting renal fibrosis. ...Immunostaining confirmed the upregulation of Sox9 in the kidney fibroblast during renal fibrosis. Delivery of Sox9 knockdown plasmid to the kidney by ultrasound microbubble-mediated gene transfer suppressed the unilateral ureteral obstruction (UUO) or folic acid-induced mouse renal fibrosis, whereas ectopic expression of Sox9 aggravated renal fibrosis. ...
Sox9 exhibits diverse roles in regulating the production of extracellular matrix proteins. Here we found that Sox9 was induced
Differential Regulation of SOX9 Protein During Chondrogenesis of Induced Pluripotent Stem Cells Versus Mesenchymal Stromal Cells: A Shortcoming for Cartilage Formation.
Diederichs S, et al. Stem Cells Dev 2016. PMID 26906619
In search for shortcomings of iPSC chondrogenesis, this study investigated whether SOX9 protein was adequately regulated during multiphase chondrogenic differentiation of two human iPSC lines in a comparable manner like during mesenchymal stromal cell (MSC) chondrogenesis. ...In iMPCs, but not MSCs, high levels of the SOX9-antagonizing hsa-miR-145 correlated with low SOX9 protein quantity. Thus, considerable iMPC heterogeneity with variable SOX9 protein levels, an altered condensation pattern, and low early SOX9 inducibility appeared as critical shortcomings of iPSC chondrogenesis. ...
In search for shortcomings of iPSC chondrogenesis, this study investigated whether SOX9 protein was adequately regulated durin …
Sox9 facilitates proliferation, differentiation and lipogenesis in primary cultured human sebocytes.
Shi G, et al. J Dermatol Sci 2017. PMID 27771230
OBJECTIVE: We investigated the effect of Sox9 on human sebocyte proliferation, differentiation and lipogenesis. METHODS: Sox9 expression was detected by immunohistochemistry in normal skin and acne lesion. ...RESULTS: Sox9 immunostaining was increased in mature sebocytes of acne lesion compared with normal skin. Expression of Sox9 mRNA and protein and PPARγ protein was elevated with cell confluent levels in sebocytes. ...
OBJECTIVE: We investigated the effect of Sox9 on human sebocyte proliferation, differentiation and lipogenesis. METHODS: So
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