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1990 1
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1998 36
1999 29
2000 33
2001 36
2002 17
2003 12
2004 15
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Page 1
The human SRY protein is present in fetal and adult Sertoli cells and germ cells.
Salas-Cortés L, et al. Int J Dev Biol 1999. PMID 10235389 Free article.
Sex determination in mammals is controlled by the Y chromosome located SRY gene. Despite recent advances towards understanding the mechanisms that regulate sex determination in mammals, the expression profile of the SRY protein in human tissues is unknown. To localize the SRY protein and determine its cellular distribution, we prepared monoclonal antibodies (mAb) against the recombinant SRY protein. ...
Sex determination in mammals is controlled by the Y chromosome located SRY gene. Despite recent advances towards understanding the me …
NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY.
Thevenet L, et al. J Biol Chem 2005. PMID 16166090 Free article.
We previously isolated SIP-1/NHERF2 as a human SRY-interacting protein. SIP-1/NHERF2, a PDZ protein, interacts with the C-terminal extremity of the human SRY protein. Here we showed that the interaction of SIP-1/NHERF2 and SRY via the SIP-1/NHERF2 PDZ1 domain is conserved in mice. However, the interaction occurs via a domain that is internal to the mouse SRY protein and involves a different recognition mechanism than human SRY. ...
We previously isolated SIP-1/NHERF2 as a human SRY-interacting protein. SIP-1/NHERF2, a PDZ protein, interacts w …
Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9.
Croft B, et al. Nat Commun 2018. PMID 30552336 Free PMC article.
Variants in two key genes, SRY and its target SOX9, are an established cause of 46,XY DSD, but the genetic basis of many DSDs remains unknown. ...These enhancers provide a hitherto missing link by which SRY activates SOX9 in humans, and establish SOX9 enhancer mutations as a significant cause of DSD....
Variants in two key genes, SRY and its target SOX9, are an established cause of 46,XY DSD, but the genetic basis of many DSDs remains …
Expression of the human SRY protein during development in normal male gonadal and sex-reversed tissues.
Salas-Cortés L, et al. J Exp Zool 2001. PMID 11748609
One of these antibodies, LSRY1.1, recognizes a protein of 27 kDa in total lysates of HeLa SRYB3, a human cell line transfected with the SRY gene under the control of the SV40 promoter. Immunocytochemical analysis in the cell lines shows nuclear localization of the SRY protein. We have studied SRY protein expression in human tissues at different stage of fetal development until adult life and have demonstrated that the SRY protein is located in the nuclei of somatic cells and germ cells in the genital ridge during testis development. ...
One of these antibodies, LSRY1.1, recognizes a protein of 27 kDa in total lysates of HeLa SRYB3, a human cell line transfected …
Phosphorylation of an N-terminal motif enhances DNA-binding activity of the human SRY protein.
Desclozeaux M, et al. J Biol Chem 1998. PMID 9525897 Free article.
To conclusively demonstrate that the human sex-determining gene SRY is affected by such a post-translational control mechanism, we have analyzed its phosphorylation status in living cells. In the present study, we show that the cyclic AMP-dependent protein kinase (PKA) phosphorylates the human SRY protein in vitro as well as in vivo on serine residues located in the N-terminal part of the protein. ...
To conclusively demonstrate that the human sex-determining gene SRY is affected by such a post-translational control mechanism …
SRY protein is expressed in ovotestis and streak gonads from human sex-reversal.
Salas-Cortés L, et al. Cytogenet Cell Genet 2000. PMID 11173859
Here, we demonstrate that the SRY protein is expressed in the tubules of streak gonads and rete testis, indicating that the SRY protein is normally expressed early during testis determination. ...This suggests that the SRY protein does not inhibit ovary development. These results confirm that other factors are needed for complete testis development, in particular, those downstream of the SRY protein....
Here, we demonstrate that the SRY protein is expressed in the tubules of streak gonads and rete testis, indicating that the …
Regulation of CATSPER1 expression by the testis-determining gene SRY.
Olivares A, et al. PLoS One 2018. PMID 30379860 Free PMC article.
CATSPER1 gene encodes a pore-forming and pH-sensing subunit of the CatSper Ca2+- permeable channel, a protein in the flagellum essential for sperm hyperactivation. ...Therefore, in this work, we sought to determine whether the human CATSPER1 gene expression is regulated by the SRY transcription factor. ...
CATSPER1 gene encodes a pore-forming and pH-sensing subunit of the CatSper Ca2+- permeable channel, a protein in the flagellum essent …
The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domains.
Poulat F, et al. J Biol Chem 1997. PMID 9054412 Free article.
The human Y-linked testis determining gene SRY encodes a protein with a DNA binding domain from the high mobility group box family. ...Here, we identify in a yeast two-hybrid screen a PDZ protein termed SIP-1, as an interacting protein with human SRY. In vitro, biochemical analysis, immunoprecipitation experiments, as well as expression of SIP-1 in human embryonic testis confirm that the two proteins can interact together. ...
The human Y-linked testis determining gene SRY encodes a protein with a DNA binding domain from the high mobility group …
Human chromosome Y and SRY.
Shah VC and Smart V. Cell Biol Int 1996 - Review. PMID 8936401
The precise location of the SRY gene on the human Y chromosome has been revealed through studies of sex reversal cases involving deletion, cross-linking and mutations of the SRY gene. ...Similarity of SRY with Sry of mice and its interaction with other genes in male sex determination are discussed....
The precise location of the SRY gene on the human Y chromosome has been revealed through studies of sex reversal cases involvi …
Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.
Peng H, et al. J Biol Chem 2009. PMID 19850934 Free PMC article.
Further, altered expression of SRY and related SOX genes contribute to oncogenesis in many human cancers. Little is known of the mechanisms by which SRY regulates its target genes. ...These results suggest that SRY has co-opted the KRAB-O protein to recruit the KAP1 repression machinery to sex determination target genes. ...
Further, altered expression of SRY and related SOX genes contribute to oncogenesis in many human cancers. Little is known of t …
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