Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 12
1995 49
1996 91
1997 110
1998 141
1999 162
2000 211
2001 243
2002 300
2003 353
2004 405
2005 414
2006 529
2007 565
2008 645
2009 740
2010 774
2011 980
2012 1038
2013 1205
2014 1280
2015 1311
2016 1371
2017 1491
2018 1488
2019 664
2020 14
Text availability
Article attribute
Article type
Publication date

Search Results

14,676 results
Results by year
Filters applied: . Clear all
Page 1
Transcription Factor STAT3 Serves as a Negative Regulator Controlling IgE Class Switching in Mice.
Dascani P, et al. Immunohorizons 2018. PMID 31026806
We investigated the specific role of STAT3 in the germinal center (GC) B cells and plasma cells for IgE class switching. Through the use of STAT3 conditional knockout (cKO) mice in a Th2-type immunization model, we demonstrated that CD2-Cre-driven STAT3 cKO mice showed elevated IgE and decreased IgG(1) in the serum and a reduction in GC formation. ...Transcription factors critical for GC and plasma cell differentiation, including Bcl-6 and Aicda, were shown to function as downstream signals of STAT3 regulation. ...
We investigated the specific role of STAT3 in the germinal center (GC) B cells and plasma cells for IgE class switching. Through the …
Hepatocytes direct the formation of a pro-metastatic niche in the liver
Lee JW, et al. Nature 2019. PMID 30842658 Free PMC article.
During early pancreatic tumorigenesis in mice, hepatocytes show activation of signal transducer and activator of transcription 3 (STAT3) signalling and increased production of serum amyloid A1 and A2 (referred to collectively as SAA). ...Genetic ablation or blockade of components of IL-6-STAT3-SAA signalling prevents the establishment of a pro-metastatic niche and inhibits liver metastasis. ...
During early pancreatic tumorigenesis in mice, hepatocytes show activation of signal transducer and activator of transcription 3 ( …
Therapeutically exploiting STAT3 activity in cancer - using tissue repair as a road map.
Huynh J, et al. Nat Rev Cancer 2019 - Review. PMID 30578415
The tightly orchestrated temporal and spatial control of signal transducer and activator of transcription 3 (STAT3) activity in epithelial, immune and stromal cells is critical for wound healing and tissue repair. ...In addition to the canonical transcriptional pathways by which STAT3 promotes stem cell-like characteristics, survival, proliferation, metastatic potential and immune evasion, cytoplasmic STAT3 activity fuels tumour growth by metabolic and other non-transcriptional mechanisms. ...
The tightly orchestrated temporal and spatial control of signal transducer and activator of transcription 3 (STAT3) activity i …
Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model.
Reichenbach N, et al. EMBO Mol Med 2019. PMID 30617153 Free PMC article.
We here show that the transcription factor Stat3 (signal transducer and activator of transcription 3), a canonical inducer of astrogliosis, is activated in an AD mouse model and human AD Therefore, using a conditional knockout approach, we deleted Stat3 specifically in astrocytes in the APP/PS1 model of AD We found that Stat3-deficient APP/PS1 mice show decreased β-amyloid levels and plaque burden. ...In summary, our data implicate Stat3-mediated astrogliosis as an important therapeutic target in AD....
We here show that the transcription factor Stat3 (signal transducer and activator of transcription 3), a canonic …
Endothelin-1 stimulates expression of cyclin D1 and S-phase kinase-associated protein 2 by activating the transcription factor STAT3 in cultured rat astrocytes.
Koyama Y, et al. J Biol Chem 2019. PMID 30670587 Free PMC article.
Activation of signal transducer and activator of transcription 3 (STAT3), a member of the STAT family of transcription factors, plays a pivotal role in inducing reactive astrocytes and glial scar formation. ...Of note, STAT3 chemical inhibition (with stattic or 5,15-diphenyl-porphine (5,15-DPP)) or siRNA-mediated STAT3 silencing reduced ET-induced BrdU incorporation. ...
Activation of signal transducer and activator of transcription 3 (STAT3), a member of the STAT family of transcription
Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery
Ito M, et al. Nature 2019. PMID 30602786
Brain T(reg) cells suppress neurotoxic astrogliosis by producing amphiregulin, a low-affinity epidermal growth factor receptor (EGFR) ligand. ...
Brain T(reg) cells suppress neurotoxic astrogliosis by producing amphiregulin, a low-affinity epidermal growth factor receptor (EGFR) …
Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis.
Martínez-Fábregas J, et al. Nat Commun 2018. PMID 30559339 Free PMC article.
This response, exemplified here either by loss of asparagine endopeptidase (AEP) or other lysosomal cysteine proteases, or by increased endocytic substrate load, is not dependent on the transcription factor EB (TFEB) but rather is triggered by STAT3 activation downstream of lysosomal oxidative stress. ...In addition, STAT3 activation due to lysosomal stress likely explains the hyperproliferative kidney disease and splenomegaly observed in AEP-deficient mice....
This response, exemplified here either by loss of asparagine endopeptidase (AEP) or other lysosomal cysteine proteases, or by increased endo …
STAT3 inhibition enhances CDN-induced STING signaling and antitumor immunity.
Pei J, et al. Cancer Lett 2019. PMID 30790684 Free article.
The activation of the STING pathway and the induced antitumor immunity could be attenuated by the feedback activation of IL-6/STAT3 pathway. ...Our work provides a rationale for the combination of STAT3 inhibitors and STING agonists in cancer immunotherapy....
The activation of the STING pathway and the induced antitumor immunity could be attenuated by the feedback activation of IL-6/STAT3 p …
14,676 results
Jump to page
Feedback