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Page 1
Chaperone-mediated autophagy regulates adipocyte differentiation.
Kaushik S, Juste YR, Lindenau K, Dong S, Macho-González A, Santiago-Fernández O, McCabe M, Singh R, Gavathiotis E, Cuervo AM. Kaushik S, et al. Among authors: santiago fernandez o. Sci Adv. 2022 Nov 18;8(46):eabq2733. doi: 10.1126/sciadv.abq2733. Epub 2022 Nov 16. Sci Adv. 2022. PMID: 36383673 Free PMC article.
Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome.
Santiago-Fernández O, Osorio FG, Quesada V, Rodríguez F, Basso S, Maeso D, Rolas L, Barkaway A, Nourshargh S, Folgueras AR, Freije JMP, López-Otín C. Santiago-Fernández O, et al. Nat Med. 2019 Mar;25(3):423-426. doi: 10.1038/s41591-018-0338-6. Epub 2019 Feb 18. Nat Med. 2019. PMID: 30778239 Free PMC article.
NF-κB signaling as a driver of ageing.
Osorio FG, Soria-Valles C, Santiago-Fernández O, Freije JM, López-Otín C. Osorio FG, et al. Among authors: santiago fernandez o. Int Rev Cell Mol Biol. 2016;326:133-74. doi: 10.1016/bs.ircmb.2016.04.003. Epub 2016 May 30. Int Rev Cell Mol Biol. 2016. PMID: 27572128 Review.
Calorie restriction and calorie-restriction mimetics activate chaperone-mediated autophagy.
Jafari M, Macho-González A, Diaz A, Lindenau K, Santiago-Fernández O, Zeng M, Massey AC, de Cabo R, Kaushik S, Cuervo AM. Jafari M, et al. Among authors: santiago fernandez o. Proc Natl Acad Sci U S A. 2024 Jun 25;121(26):e2317945121. doi: 10.1073/pnas.2317945121. Epub 2024 Jun 18. Proc Natl Acad Sci U S A. 2024. PMID: 38889154 Free PMC article.
Reduced endosomal microautophagy activity in aging associates with enhanced exocyst-mediated protein secretion.
Krause GJ, Diaz A, Jafari M, Khawaja RR, Agullo-Pascual E, Santiago-Fernández O, Richards AL, Chen KH, Dmitriev P, Sun Y, See SK, Abdelmohsen K, Mazan-Mamczarz K, Krogan NJ, Gorospe M, Swaney DL, Sidoli S, Bravo-Cordero JJ, Kampmann M, Cuervo AM. Krause GJ, et al. Among authors: santiago fernandez o. Aging Cell. 2022 Oct;21(10):e13713. doi: 10.1111/acel.13713. Epub 2022 Sep 18. Aging Cell. 2022. PMID: 36116133 Free PMC article.
Partial Loss of USP9X Function Leads to a Male Neurodevelopmental and Behavioral Disorder Converging on Transforming Growth Factor β Signaling.
Johnson BV, Kumar R, Oishi S, Alexander S, Kasherman M, Vega MS, Ivancevic A, Gardner A, Domingo D, Corbett M, Parnell E, Yoon S, Oh T, Lines M, Lefroy H, Kini U, Van Allen M, Grønborg S, Mercier S, Küry S, Bézieau S, Pasquier L, Raynaud M, Afenjar A, Billette de Villemeur T, Keren B, Désir J, Van Maldergem L, Marangoni M, Dikow N, Koolen DA, VanHasselt PM, Weiss M, Zwijnenburg P, Sa J, Reis CF, López-Otín C, Santiago-Fernández O, Fernández-Jaén A, Rauch A, Steindl K, Joset P, Goldstein A, Madan-Khetarpal S, Infante E, Zackai E, Mcdougall C, Narayanan V, Ramsey K, Mercimek-Andrews S, Pena L, Shashi V; Undiagnosed Diseases Network; Schoch K, Sullivan JA, Pinto E Vairo F, Pichurin PN, Ewing SA, Barnett SS, Klee EW, Perry MS, Koenig MK, Keegan CE, Schuette JL, Asher S, Perilla-Young Y, Smith LD, Rosenfeld JA, Bhoj E, Kaplan P, Li D, Oegema R, van Binsbergen E, van der Zwaag B, Smeland MF, Cutcutache I, Page M, Armstrong M, Lin AE, Steeves MA, Hollander ND, Hoffer MJV, Reijnders MRF, Demirdas S, Koboldt DC, Bartholomew D, Mosher TM, Hickey SE, Shieh C, Sanchez-Lara PA, Graham JM Jr, Tezcan K, Schaefer GB, Danylchuk NR, Asamoah A, Jackson KE, Yachelevich N, Au M, Pérez-Jurado LA… See abstract for full author list ➔ Johnson BV, et al. Among authors: santiago fernandez o. Biol Psychiatry. 2020 Jan 15;87(2):100-112. doi: 10.1016/j.biopsych.2019.05.028. Epub 2019 Jun 29. Biol Psychiatry. 2020. PMID: 31443933 Free PMC article.
Autophagy gene expression in skeletal muscle of older individuals is associated with physical performance, muscle volume and mitochondrial function in the study of muscle, mobility and aging (SOMMA).
Coen PM, Huo Z, Tranah GJ, Barnes HN, Zhang X, Wolff CA, Wu K, Cawthon PM, Hepple RT, Toledo FGS, Evans DS, Santiago-Fernández O, Cuervo AM, Kritchevsky SB, Newman AB, Cummings SR, Esser KA. Coen PM, et al. Among authors: santiago fernandez o. Aging Cell. 2024 Jun;23(6):e14118. doi: 10.1111/acel.14118. Epub 2024 Apr 16. Aging Cell. 2024. PMID: 38627910 Free PMC article.
Giant tortoise genomes provide insights into longevity and age-related disease.
Quesada V, Freitas-Rodríguez S, Miller J, Pérez-Silva JG, Jiang ZF, Tapia W, Santiago-Fernández O, Campos-Iglesias D, Kuderna LFK, Quinzin M, Álvarez MG, Carrero D, Beheregaray LB, Gibbs JP, Chiari Y, Glaberman S, Ciofi C, Araujo-Voces M, Mayoral P, Arango JR, Tamargo-Gómez I, Roiz-Valle D, Pascual-Torner M, Evans BR, Edwards DL, Garrick RC, Russello MA, Poulakakis N, Gaughran SJ, Rueda DO, Bretones G, Marquès-Bonet T, White KP, Caccone A, López-Otín C. Quesada V, et al. Among authors: santiago fernandez o. Nat Ecol Evol. 2019 Jan;3(1):87-95. doi: 10.1038/s41559-018-0733-x. Epub 2018 Dec 3. Nat Ecol Evol. 2019. PMID: 30510174 Free PMC article.
Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.
Osorio FG, Soria-Valles C, Santiago-Fernández O, Bernal T, Mittelbrunn M, Colado E, Rodríguez F, Bonzon-Kulichenko E, Vázquez J, Porta-de-la-Riva M, Cerón J, Fueyo A, Li J, Green AR, Freije JM, López-Otín C. Osorio FG, et al. Among authors: santiago fernandez o. Nat Med. 2016 Jan;22(1):91-6. doi: 10.1038/nm.4013. Epub 2015 Dec 21. Nat Med. 2016. PMID: 26692333