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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1952 1
1956 2
1957 1
1958 5
1960 3
1962 1
1965 5
1966 12
1967 7
1968 14
1969 20
1970 11
1971 25
1972 21
1973 27
1974 36
1975 31
1976 35
1977 39
1978 28
1979 53
1980 44
1981 113
1982 91
1983 81
1984 60
1985 88
1986 82
1987 70
1988 74
1989 87
1990 66
1991 69
1992 82
1993 112
1994 110
1995 132
1996 123
1997 146
1998 155
1999 180
2000 198
2001 178
2002 197
2003 231
2004 283
2005 212
2006 214
2007 240
2008 268
2009 304
2010 394
2011 488
2012 545
2013 652
2014 640
2015 685
2016 712
2017 642
2018 659
2019 366
2020 6
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9,628 results
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Page 1
Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment.
Sandquist M and Wong HR. Expert Rev Clin Immunol 2014 - Review. PMID 25142036 Free PMC article.
Biomarkers have great potential to improve the diagnosis and treatment of sepsis. The available literature supports the potential utility of sTREM-1, IL-27, suPAR, neutrophil CD64, presepsin, cfDNA and miRNAs as novel diagnostic, prognostic and treatment response biomarkers. The future of sepsis biomarkers lies in extensive validation studies of such novel biomarkers across heterogeneous populations and exploration of their power in combination. ...
Biomarkers have great potential to improve the diagnosis and treatment of sepsis. The available literature supports the potent …
Early-onset neonatal sepsis.
Simonsen KA, et al. Clin Microbiol Rev 2014 - Review. PMID 24396135 Free PMC article.
The diagnosis of neonatal sepsis is based on a combination of clinical presentation; the use of nonspecific markers, including C-reactive protein and procalcitonin (where available); blood cultures; and the use of molecular methods, including PCR. ...Viruses, in particular enteroviruses, parechoviruses, and herpes simplex virus (HSV), should be considered in the differential diagnosis. ...
The diagnosis of neonatal sepsis is based on a combination of clinical presentation; the use of nonspecific markers, including …
Pediatric Sepsis.
Prusakowski MK and Chen AP. Emerg Med Clin North Am 2017 - Review. PMID 27908329
Pediatric sepsis is distinct from adult sepsis in its definitions, clinical presentations, and management. Recognition of pediatric sepsis is complicated by the various pediatric-specific comorbidities that contribute to its mortality and the age- and development-specific vital sign and clinical parameters that obscure its recognition. This article outlines the clinical presentation and management of sepsis in neonates, infants, and children, and highlights some key populations who require specialized care....
Pediatric sepsis is distinct from adult sepsis in its definitions, clinical presentations, and management. Recognition of pedi …
Molecular assays for the diagnosis of sepsis in neonates.
Pammi M, et al. Cochrane Database Syst Rev 2017 - Review. PMID 28236648 Free PMC article.
BACKGROUND: Microbial cultures for diagnosis of neonatal sepsis have low sensitivity and reporting delay. Advances in molecular microbiology have fostered new molecular assays that are rapid and may improve neonatal outcomes. OBJECTIVES: To assess the diagnostic accuracy of various molecular methods for the diagnosis of culture-positive bacterial and fungal sepsis in neonates and to explore heterogeneity among studies by analyzing subgroups classified by gestational age and type of sepsis onset and compare molecular tests with one another. ...
BACKGROUND: Microbial cultures for diagnosis of neonatal sepsis have low sensitivity and reporting delay. Advances in molecula …
Sepsis and septic shock: current approaches to management.
Thompson K, et al. Intern Med J 2019 - Review. PMID 30754087
Sepsis, defined as life-threatening organ dysfunction due to a dysregulated host response to infection, is recognised by the World Health Organization as a global health priority. ...While early recognition and improved management of the acute episode are important steps in reducing death and disability from sepsis, a substantial reduction in the burden of sepsis-related disease requires action across the entire healthcare system. ...
Sepsis, defined as life-threatening organ dysfunction due to a dysregulated host response to infection, is recognised by the World He
[Biomarkers for the early diagnosis of sepsis].
Yuan Z, et al. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019. PMID 30914107 Chinese.
More than 170 different biomarkers have been assessed for potential use in sepsis, more for prognosis than for diagnosis. None have sufficient specificity or sensitivity to be routinely employed in clinical practice. Therefore, it is essential for clinicians to seek more specific and sensitive biomarkers to early identify and diagnosis of sepsis patients, and further assess the severity and predict prognosis. ...
More than 170 different biomarkers have been assessed for potential use in sepsis, more for prognosis than for diagnosis. None …
[Inflammatory markers in diagnosis and prognosis of abdominal sepsis].
Lebedev NV, et al. Khirurgiia (Mosk) 2018. PMID 30531745 Russian.
Early diagnostics and targeted therapy are the key points for improving of sepsis outcome. At present, researchers around the world have proposed a large number of biological markers for diagnosing sepsis and predicting mortality. ...We have analyzed literature data and summarized information on the possible use of biological markers and their combinations in the early detection of sepsis, for monitoring sepsis and predicting its outcome....
Early diagnostics and targeted therapy are the key points for improving of sepsis outcome. At present, researchers around the world h …
Multicentre validation of a sepsis prediction algorithm using only vital sign data in the emergency department, general ward and ICU.
Mao Q, et al. BMJ Open 2018 - Clinical Trial. PMID 29374661 Free PMC article.
OBJECTIVES: We validate a machine learning-based sepsis-prediction algorithm (InSight) for the detection and prediction of three sepsis-related gold standards, using only six vital signs. ...CONCLUSIONS: InSight outperforms existing sepsis scoring systems in identifying and predicting sepsis, severe sepsis and septic shock. ...
OBJECTIVES: We validate a machine learning-based sepsis-prediction algorithm (InSight) for the detection and prediction of three s
Sepsis in Pediatric Cardiac Intensive Care.
Wheeler DS and Wong HR. Pediatr Crit Care Med 2016 - Review. PMID 27490609 Free PMC article.
OBJECTIVES: In this review, we will discuss risk factors for developing sepsis; the role of biomarkers in establishing an early diagnosis, in monitoring therapeutic efficacy, in stratification, and for the identification of sepsis endotypes; and the pathophysiology and management of severe sepsis and septic shock, with an emphasis on the impact of sepsis on cardiovascular function. ...CONCLUSIONS: There is a lot of excitement in the field of sepsis research today. Scientific advances in the diagnosis and clinical staging of sepsis, as well as a personalized approach to the treatment of sepsis, offer tremendous promise for the future. ...
OBJECTIVES: In this review, we will discuss risk factors for developing sepsis; the role of biomarkers in establishing an early di
New Microbiological Techniques in the Diagnosis of Bloodstream Infections.
Idelevich EA, et al. Dtsch Arztebl Int 2018 - Review. PMID 30678752 Free PMC article.
RESULTS: A number of technical advances now enable more rapid microbiological diagnosis of bloodstream infections. DNA- based techniques for the direct detection of pathogenic organisms in whole blood have not yet become established in routine use because of various limitations. On the other hand, matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry (MS) has become available for routine use in clinical laboratories and has markedly shortened the time to diagnosis after blood samples that have been cultured in automated blood-culture systems turn positive. ...
RESULTS: A number of technical advances now enable more rapid microbiological diagnosis of bloodstream infections. DNA- based techniq …
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