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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1948 1
1966 4
1967 16
1968 18
1969 19
1970 27
1971 40
1972 34
1973 30
1974 39
1975 23
1976 31
1977 31
1978 35
1979 38
1980 31
1981 42
1982 41
1983 41
1984 39
1985 62
1986 51
1987 56
1988 55
1989 87
1990 78
1991 80
1992 82
1993 100
1994 105
1995 151
1996 135
1997 143
1998 147
1999 160
2000 197
2001 187
2002 239
2003 278
2004 315
2005 350
2006 377
2007 414
2008 456
2009 436
2010 524
2011 638
2012 653
2013 702
2014 781
2015 816
2016 798
2017 848
2018 829
2019 386
2020 5
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11,185 results
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Page 1
Sepsis and septic shock.
Cecconi M, et al. Lancet 2018 - Review. PMID 29937192
Sepsis is a common condition that is associated with unacceptably high mortality and, for many of those who survive, long-term morbidity. ...In 2016, a new definition of sepsis (Sepsis-3) was developed. Sepsis is now defined as infection with organ dysfunction. This definition codifies organ dysfunction using the Sequential Organ Failure Assessment score. ...
Sepsis is a common condition that is associated with unacceptably high mortality and, for many of those who survive, long-term
Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations.
Fleischmann C, et al. Am J Respir Crit Care Med 2016. PMID 26414292
RATIONALE: Reducing the global burden of sepsis, a recognized global health challenge, requires comprehensive data on the incidence and mortality on a global scale. ...Hospital mortality was 17% for sepsis and 26% for severe sepsis during this period. There were no population-level sepsis incidence estimates from lower-income countries, which limits the prediction of global cases and deaths. ...
RATIONALE: Reducing the global burden of sepsis, a recognized global health challenge, requires comprehensive data on the incidence a …
Time to Treatment and Mortality during Mandated Emergency Care for Sepsis.
Seymour CW, et al. N Engl J Med 2017. PMID 28528569 Free PMC article.
Multilevel models were used to assess the associations between the time until completion of the 3-hour bundle and risk-adjusted mortality. ...CONCLUSIONS: More rapid completion of a 3-hour bundle of sepsis care and rapid administration of antibiotics, but not rapid completion of an initial bolus of intravenous fluids, were associated with lower risk-adjusted in-hospital mortality. ...
Multilevel models were used to assess the associations between the time until completion of the 3-hour bundle and risk-adjusted mortality
Severe Sepsis and Septic Shock Trials (ProCESS, ARISE, ProMISe): What is Optimal Resuscitation?
Osborn TM. Crit Care Clin 2017 - Review. PMID 28284298
Between 2014 and 2015, 3 independent, multicenter, randomized controlled trials evaluated early goal-directed therapy (EGDT) in severe sepsis and septic shock: Protocolized Care for Early Septic Shock (ProCESS) from the United States; Australasian Resuscitation in Sepsis Evaluation (ARISE), and Protocolised Management in Sepsis (ProMISe) in the United Kingdom. ...How should we define usual care for sepsis given these study findings? Furthermore, the definition of sepsis has now been updated. ...
Between 2014 and 2015, 3 independent, multicenter, randomized controlled trials evaluated early goal-directed therapy (EGDT) in severe se
The global burden of paediatric and neonatal sepsis: a systematic review.
Fleischmann-Struzek C, et al. Lancet Respir Med 2018 - Review. PMID 29508706
Mortality ranged from 1% to 5% for sepsis and 9% to 20% for severe sepsis. The population-level estimate for neonatal sepsis was 2202 (95% CI 1099-4360) per 100 000 livebirths, with mortality between 11% and 19%. ...Robust epidemiological monitoring to define global sepsis incidence and mortality in children is urgently needed....
Mortality ranged from 1% to 5% for sepsis and 9% to 20% for severe sepsis. The population-level estimate for neonatal
Liver dysfunction in sepsis.
Woźnica EA, et al. Adv Clin Exp Med 2018 - Review. PMID 29558045 Free article.
Despite continuous progress in medicine, sepsis remains the main cause of deaths in the intensive care unit. Liver failure complicating sepsis/septic shock has a significant impact on mortality in this group of patients. ...Clinical manifestations of sepsis-associated liver dysfunction include hypoxic hepatitis, sepsis-induced cholestasis and dysfunction of protein synthesis manifesting with, e.g., coagulopathies. ...
Despite continuous progress in medicine, sepsis remains the main cause of deaths in the intensive care unit. Liver failure complicati …
Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program.
Ferrer R, et al. Crit Care Med 2014. PMID 24717459
Delay in the initiation of appropriate antibiotic therapy has been recognized as a risk factor for mortality. To perform a retrospective analysis on the Surviving Sepsis Campaign database to evaluate the relationship between timing of antibiotic administration and mortality. ...INTERVENTIONS: Antibiotic administration and hospital mortality. MEASUREMENTS AND MAIN RESULTS: A total of 17,990 patients received antibiotics after sepsis identification and were included in the analysis. ...
Delay in the initiation of appropriate antibiotic therapy has been recognized as a risk factor for mortality. To perform a retrospect …
Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012.
Kaukonen KM, et al. JAMA 2014 - Clinical Trial. PMID 24638143
IMPORTANCE: Severe sepsis and septic shock are major causes of mortality in intensive care unit (ICU) patients. It is unknown whether progress has been made in decreasing their mortality rate. ...In the absence of comorbidities and older age, mortality was less than 5%. CONCLUSIONS AND RELEVANCE: In critically ill patients in Australia and New Zealand with severe sepsis with and without shock, there was a decrease in mortality from 2000 to 2012. ...
IMPORTANCE: Severe sepsis and septic shock are major causes of mortality in intensive care unit (ICU) patients. It is unknown …
Does Early and Appropriate Antibiotic Administration Improve Mortality in Emergency Department Patients with Severe Sepsis or Septic Shock?
Sherwin R, et al. J Emerg Med 2017 - Review. PMID 28916120
CONCLUSIONS: Patients with severe sepsis and septic shock should receive early and appropriate antibiotics in the emergency department. Patients with septic shock who received appropriate antimicrobial therapy within 1 h of recognition had the greatest benefit in mortality....
CONCLUSIONS: Patients with severe sepsis and septic shock should receive early and appropriate antibiotics in the emergency departmen …
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