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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 5
1947 6
1948 8
1949 5
1950 10
1951 18
1952 14
1953 21
1954 30
1955 16
1956 12
1957 13
1958 20
1959 5
1960 10
1961 12
1962 14
1963 21
1964 26
1965 29
1966 16
1967 20
1968 14
1969 23
1970 27
1971 27
1972 32
1973 47
1974 79
1975 96
1976 96
1977 105
1978 95
1979 77
1980 91
1981 117
1982 148
1983 174
1984 238
1985 265
1986 274
1987 294
1988 301
1989 271
1990 280
1991 294
1992 393
1993 450
1994 554
1995 574
1996 646
1997 654
1998 714
1999 795
2000 979
2001 1025
2002 1093
2003 1051
2004 1164
2005 1233
2006 1429
2007 1405
2008 1612
2009 1658
2010 1802
2011 2119
2012 2142
2013 2156
2014 2212
2015 2302
2016 2272
2017 2163
2018 2072
2019 1220
2020 35
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38,054 results
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Page 1
Tricyclic Sesquiterpenes from Marine Origin.
Le Bideau F, et al. Chem Rev 2017 - Review. PMID 28379015
The structure elucidation, biosynthesis, and biological activity of marine carbotricyclic sesquiterpene compounds are reviewed from the pioneering results to the end of 2015. ...Tricyclic sesquiterpenes constitute an important group of natural products. Their structural diversity and biological activities have generated further interest in the field of drug discovery research, although the exact mechanisms of action of these species are not well known. ...
The structure elucidation, biosynthesis, and biological activity of marine carbotricyclic sesquiterpene compounds are reviewed from t …
Tremulane sesquiterpenes from cultures of the basidiomycete Irpex lacteus.
Ding JH, et al. Fitoterapia 2018. PMID 29221704
Five new tremulane sesquiterpenes, named irlactins F-J (1-5), were isolated from cultures of the basidiomycete Irpex lacteus together with two known analogues (6 and 7). ...
Five new tremulane sesquiterpenes, named irlactins F-J (1-5), were isolated from cultures of the basidiomycete Irpex lacteus together …
Cytotoxic activity of halogenated sesquiterpenes from Laurencia dendroidea.
Barcellos Marini M, et al. Phytother Res 2018. PMID 29480520
These data demonstrated the effective apoptosis-inducing activity of the sesquiterpene (-)-elatol and obtusol in the treatment of Colo-205 strain. Therefore, more studies should be done so that the sesquiterpenes (-)-elatol and obtusol might become promising chemotherapy....
These data demonstrated the effective apoptosis-inducing activity of the sesquiterpene (-)-elatol and obtusol in the treatment of Col …
Diterpenes and Sesquiterpenes from the Marine Algicolous Fungus Trichoderma harzianum X-5.
Song YP, et al. J Nat Prod 2018. PMID 30351930
Six new terpenes, including one harziane diterpene, 3 R-hydroxy-9 R,10 R-dihydroharzianone (1), one proharziane diterpene, 11 R-methoxy-5,9,13-proharzitrien-3-ol (2), three cyclonerane sesquiterpenes, 11-methoxy-9-cycloneren-3,7-diol (3), 10-cycloneren-3,5,7-triol (4), and methyl 3,7-dihydroxy-15-cycloneranate (5), and one acorane sesquiterpene, 8-acoren-3,11-diol (6), were isolated from the culture of Trichoderma harzianum X-5, an endophytic fungus obtained from the marine brown alga Laminaria japonica. ...
Six new terpenes, including one harziane diterpene, 3 R-hydroxy-9 R,10 R-dihydroharzianone (1), one proharziane diterpene, 11 R-methoxy-5,9, …
β-caryophyllene Delivery Systems: Enhancing the Oral Pharmacokinetic and Stability
Santos PS, et al. Curr Pharm Des 2018 - Review. PMID 30207226
Despite this recognized potential, this hydrophobic compound is a volatile and acid-sensitive sesquiterpene that readily oxidizes when exposed to air, and has low bioavailability in oral formulations. ...These systems proved to be promising for improving solubility, stability and controlled release of this pharmacological relevant sesquiterpene. ...
Despite this recognized potential, this hydrophobic compound is a volatile and acid-sensitive sesquiterpene that readily oxidizes whe …
Lepistatins A-C, chlorinated sesquiterpenes from the cultured basidiomycete Lepista sordida.
Kang HS, et al. Phytochemistry 2017. PMID 28803994
Three new chlorinated sesquiterpenes, named lepistatins A-C, were isolated from the culture broth of Basidiomycete Lepista sordida. ...This indicates that lepistatins A-C probably possess a new sesquiterpene scaffold derived from the common precursor, trans-humulyl cation, by an alternative cyclization....
Three new chlorinated sesquiterpenes, named lepistatins A-C, were isolated from the culture broth of Basidiomycete Lepista sordida. . …
Trichocarotins A-H and trichocadinin A, nine sesquiterpenes from the marine-alga-epiphytic fungus Trichoderma virens.
Shi ZZ, et al. Bioorg Chem 2018. PMID 30176571
In addition to CAF-603, 14-hydroxy CAF-603 (trichocarane B), 7-β-hydroxy CAF-603, and trichocarane A, eight new carotane sesquiterpenes, trichocarotins A-H, and one new cadinane sesquiterpene, trichocadinin A, were isolated from the culture of Trichoderma virens Y13-3, obtained from the surface of a marine red alga. ...These compounds represent two rarely occurring sesquiterpene types from filamentous fungi, and six of them feature potent inhibition against some marine plankton species....
In addition to CAF-603, 14-hydroxy CAF-603 (trichocarane B), 7-β-hydroxy CAF-603, and trichocarane A, eight new carotane sesquiterpenes
Enzyme-mediated synthesis of sesquiterpenes.
Serra S. Nat Prod Commun 2015 - Review. PMID 25920240
This review article focuses mainly on the scientific developments concerning the enzyme-mediated synthesis of sesquiterpenes which have been reported in the academic and patent literature during the last twenty years. Nevertheless, this is not a comprehensive description of every single biotransformation involving sesquiterpenes. Only synthetic approaches that have represented a new and innovative perspective from a scientific standpoint are reported. ...
This review article focuses mainly on the scientific developments concerning the enzyme-mediated synthesis of sesquiterpenes which ha …
Synthesis of Neurotrophic Seco-prezizaane Sesquiterpenes (1R,10S)-2-Oxo-3,4-dehydroneomajucin, (2S)-Hydroxy-3,4-dehydroneomajucin, and (-)-Jiadifenin.
Cheng X and Micalizio GC. J Am Chem Soc 2016. PMID 26785051 Free PMC article.
An asymmetric approach to the synthesis of neurotrophic seco-prezizaane sesquiterpenes is described that is based on the strategic application of a hydroxyl-directed metallacycle-mediated [2 + 2 + 2] annulation and an intramolecular radical cyclization cascade. ...
An asymmetric approach to the synthesis of neurotrophic seco-prezizaane sesquiterpenes is described that is based on the strategic ap …
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