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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1991 6
1992 23
1993 33
1994 37
1995 59
1996 61
1997 58
1998 74
1999 59
2000 67
2001 58
2002 38
2003 42
2004 40
2005 40
2006 42
2007 37
2008 47
2009 47
2010 49
2011 49
2012 51
2013 35
2014 39
2015 40
2016 32
2017 25
2018 18
2019 10
2020 0
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1,138 results
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Page 1
Natural RNA circles function as efficient microRNA sponges
Hansen TB, et al. Nature 2013. PMID 23446346
We further show that the testis-specific circRNA, sex-determining region Y (Sry), serves as a miR-138 sponge, suggesting that miRNA sponge effects achieved by circRNA formation are a general phenomenon. ...
We further show that the testis-specific circRNA, sex-determining region Y (Sry), serves as a miR-138 sponge, su …
Bovine Sex Determining Region Y: Cloning, Optimized Expression, and Purification.
Soleymani B, et al. Anim Biotechnol 2017. PMID 27715460
Sex determining region Y gene (SRY) is located on Y chromosome and encodes a protein with 229 amino acids. In this study, ORF region of SRY with a length of 690 bp was synthesized using PCR and ligated to pET28a (+), then transformed in E.coli DH5α. ...Results showed that temperature points and different concentrations of IPTG and glucose had a significant effect (p < 0.01) on total protein and recombinant bovine SRY. ...
Sex determining region Y gene (SRY) is located on Y chromosome and encodes a protein with 229 amin
Label-free detection of sex determining region Y (SRY) via capacitive biosensor.
Sivashankar S, et al. Conf Proc IEEE Eng Med Biol Soc 2016. PMID 28269241
In this work, we present for the first time, the use of a simple fractal capacitive biosensor for the quantification and detection of sex-determining region Y (SRY) genes. This section of genetic code, which is found on the Y chromosome, finds importance for study as it causes fetuses to develop characteristics of male sex-like gonads when a mutation occurs. ...
In this work, we present for the first time, the use of a simple fractal capacitive biosensor for the quantification and detection of sex
Sex reversal following deletion of a single distal enhancer of Sox9.
Gonen N, et al. Science 2018. PMID 29903884 Free PMC article.
Sox9, a direct target of SRY, is pivotal in mammalian sex determination. In vivo high-throughput chromatin accessibility techniques, transgenic assays, and genome editing revealed several novel gonadal regulatory elements in the 2-megabase gene desert upstream of Sox9 Although others are redundant, enhancer 13 (Enh13), a 557-base pair element located 565 kilobases 5' from the transcriptional start site, is essential to initiate mouse testis development; its deletion results in XY females with Sox9 transcript levels equivalent to those in XX gonads. ...Enh13 is conserved and embedded within a 32.5-kilobase region whose deletion in humans is associated with XY sex reversal, suggesting that it is also critical in humans....
Sox9, a direct target of SRY, is pivotal in mammalian sex determination. In vivo high-throughput chromatin accessibility techniques, …
Sry and SoxE genes: How they participate in mammalian sex determination and gonadal development?
She ZY and Yang WX. Semin Cell Dev Biol 2017 - Review. PMID 27481580
In mammals, sex determination defines the differentiation of the bipotential genital ridge into either testes or ovaries. Sry, the mammalian Y-chromosomal testis-determining gene, is a master regulator of male sex determination. ...The mutual antagonisms between male and female sex-determining pathways are crucial in not just the initiation but also the maintenance of the somatic sex of the gonad throughout the organism's lifetime. ...
In mammals, sex determination defines the differentiation of the bipotential genital ridge into either testes or ovaries. Sry, the ma …
Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9.
Croft B, et al. Nat Commun 2018. PMID 30552336 Free PMC article.
Disorders of sex development (DSDs) are conditions affecting development of the gonads or genitalia. Variants in two key genes, SRY and its target SOX9, are an established cause of 46,XY DSD, but the genetic basis of many DSDs remains unknown. ...This is the first study to identify SOX9 enhancers that, when duplicated or deleted, result in 46,XX or 46,XY sex reversal, respectively. ...
Disorders of sex development (DSDs) are conditions affecting development of the gonads or genitalia. Variants in two key genes, SRY a …
Identification of sex-determining region Y (SRY) in maternal plasma after paternal lymphocyte immunization: is it possible?
Machado IN, et al. Am J Reprod Immunol 2012. PMID 22032865
This study evaluated the applicability of fetal sex determination using fragments of sex-determining region Y (SRY) in the plasma of women submitted to paternal lymphocyte immunization. ...For the 26 pregnant women, the results of the identification of sex -determining in maternal plasma were completely in agreement with the infant sex. ...
This study evaluated the applicability of fetal sex determination using fragments of sex-determining region Y
XX sex chromosome complement promotes atherosclerosis in mice.
AlSiraj Y, et al. Nat Commun 2019. PMID 31201301 Free PMC article.
While sex hormones such as estrogens decrease CAD risk, hormone replacement therapy increases risk. Biological sex is determined by sex hormones and chromosomes, but effects of sex chromosomes on circulating lipids and atherosclerosis are unknown. ...Together, our results show that an XX sex chromosome complement promotes the bioavailability of dietary fat to accelerate atherosclerosis....
While sex hormones such as estrogens decrease CAD risk, hormone replacement therapy increases risk. Biological sex is determin …
Defective calmodulin-mediated nuclear transport of the sex-determining region of the Y chromosome (SRY) in XY sex reversal.
Sim H, et al. Mol Endocrinol 2005. PMID 15746192
The sex-determining region of the Y chromosome (SRY) plays a key role in human sex determination, as mutations in SRY can cause XY sex reversal. ...The SRY N-terminal NLS (n-NLS) binds calmodulin (CaM) in vitro, and here we show that this protein interaction is reduced in vivo by calmidazolium, a CaM antagonist. ...
The sex-determining region of the Y chromosome (SRY) plays a key role in human sex determination, as muta …
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