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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
1969 1
1971 2
1972 1
1980 1
1986 1
1988 1
1991 2
1992 3
1993 4
1995 3
1996 2
1997 4
1998 2
1999 6
2000 7
2001 4
2002 6
2003 4
2004 8
2005 10
2006 5
2007 2
2008 5
2009 3
2010 3
2011 5
2012 2
2013 2
2014 5
2015 2
2016 4
2017 3
2018 11
2019 1
2020 0
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122 results
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Page 1
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
Singer M, et al. JAMA 2016. PMID 26903338 Free PMC article.
Multiple definitions and terminologies are currently in use for sepsis, septic shock, and organ dysfunction, leading to discrepancies in reported incidence and observed mortality. ...Septic shock should be defined as a subset of sepsis in which particularly profound circulatory, cellular, and metabolic abnormalities are associated with a greater risk of mortality than with sepsis alone. ...
Multiple definitions and terminologies are currently in use for sepsis, septic shock, and organ dysfunction, leading to …
Septic shock-3 vs 2: an analysis of the ALBIOS study.
Vasques F, et al. Crit Care 2018 - Clinical Trial. PMID 30261898 Free PMC article.
BACKGROUND: A reanalysis of the ALBIOS trial suggested that patients with septic shock - defined by vasopressor-dependent hypotension in the presence of severe sepsis (Shock-2) - had a survival benefit when treated with albumin. The new septic shock definition (Shock-3) added the criterion of a lactate threshold of 2 mmol/L. We investigated how the populations defined according to Shock-2 and Shock-3 differed and whether the albumin benefit would be confirmed. ...
BACKGROUND: A reanalysis of the ALBIOS trial suggested that patients with septic shock - defined by vasopressor-dependent hypo …
Refractory septic shock: our pragmatic approach.
Nandhabalan P, et al. Crit Care 2018. PMID 30231909 Free PMC article.
Despite timely intervention, there exists a small subgroup of patients with septic shock who develop progressive multi-organ failure. ...In this article, we describe a pragmatic, multi-faceted approach to managing patients with refractory septic shock based on our experience of toxin-mediated sepsis in a specialist referral centre. ...
Despite timely intervention, there exists a small subgroup of patients with septic shock who develop progressive multi-organ f …
Six subphenotypes in septic shock: Latent class analysis of the PROWESS Shock study.
Gårdlund B, et al. J Crit Care 2018. PMID 29933169
PURPOSE: Septic shock is a highly heterogeneous condition which is part of the challenge in its diagnosis and treatment. In this study we aim to identify clinically relevant subphenotypes of septic shock using a novel statistic al approach. ...RESULTS: LCA identified six different, clinically meaningful subphenotypes of septic shock each with a typical profile: (1) "Uncomplicated Septic Shock, (2) "Pneumonia with adult respiratory distress syndrome (ARDS)", (3) "Postoperative Abdominal", (4) "Severe Septic Shock", (5): "Pneumonia with ARDS and multiple organ dysfunction syndrome (MODS)", (6) "Late Septic Shock". ...
PURPOSE: Septic shock is a highly heterogeneous condition which is part of the challenge in its diagnosis and treatment. In th …
Definitions and pathophysiology of vasoplegic shock.
Lambden S, et al. Crit Care 2018 - Review. PMID 29980217 Free PMC article.
The vasoplegic syndrome is encountered in many clinical scenarios, including septic shock, post-cardiac bypass and after surgery, burns and trauma, but despite this, uniform clinical definitions are lacking, which renders translational research in this area challenging. ...
The vasoplegic syndrome is encountered in many clinical scenarios, including septic shock, post-cardiac bypass and after surge …
Proof of concept study of mass cytometry in septic shock patients reveals novel immune alterations.
Gossez M, et al. Sci Rep 2018. PMID 30470767 Free PMC article.
So far, CyTOF has not been used in sepsis - a condition characterized by complex immune disorders. Here, we evaluated feasibility of CyTOF analysis in patients with septic shock. We designed a mass cytometry panel of 25 extracellular markers to study mononuclear cells from 5 septic shock patients and 5 healthy donors. ...
So far, CyTOF has not been used in sepsis - a condition characterized by complex immune disorders. Here, we evaluated feasibility of …
Judging quality of current septic shock definitions and criteria.
Shankar-Hari M, et al. Crit Care 2015. PMID 26702879 Free PMC article.
Septic shock definitions are being revisited. We assess the feasibility, reliability, and validity characteristics of the current definitions and criteria of septic shock. Septic shock is conceptualised as cardiovascular dysfunction, tissue perfusion and cellular abnormalities caused by infection. ...
Septic shock definitions are being revisited. We assess the feasibility, reliability, and validity characteristics of the curr
Prediction of pediatric sepsis mortality within 1 h of intensive care admission.
Schlapbach LJ, et al. Intensive Care Med 2017 - Clinical Trial. PMID 28220227
PURPOSE: The definitions of sepsis and septic shock have recently been revised in adults, but contemporary data are needed to inform similar approaches in children. METHODS: Multicenter cohort study including children <16 years admitted with sepsis or septic shock to ICUs in Australia and New Zealand in the period 2012-2015. ...
PURPOSE: The definitions of sepsis and septic shock have recently been revised in adults, but contemporary data are nee …
Prognosis of patients excluded by the definition of septic shock based on their lactate levels after initial fluid resuscitation: a prospective multi-center observational study.
Ko BS, et al. Crit Care 2018 - Clinical Trial. PMID 29475445 Free PMC article.
BACKGROUND: Septic shock can be defined both by the presence of hyperlactatemia and need of vasopressors. Lactate levels should be measured after volume resuscitation (as per the Sepsis-3 definition). ...METHODS: This observational study was performed using a prospective, multi-center registry of septic shock, with the participation of 10 hospitals in the Korean Shock Society, between October 2015 and February 2017. ...
BACKGROUND: Septic shock can be defined both by the presence of hyperlactatemia and need of vasopressors. Lactate levels shoul …
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