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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 7
1966 22
1967 12
1968 13
1969 19
1970 15
1971 20
1972 20
1973 16
1974 12
1975 9
1976 23
1977 12
1978 27
1979 15
1980 20
1981 26
1982 18
1983 28
1984 32
1985 33
1986 25
1987 34
1988 27
1989 46
1990 37
1991 43
1992 32
1993 40
1994 37
1995 43
1996 40
1997 31
1998 45
1999 45
2000 63
2001 67
2002 64
2003 84
2004 95
2005 74
2006 103
2007 105
2008 92
2009 97
2010 85
2011 110
2012 99
2013 102
2014 114
2015 101
2016 102
2017 113
2018 100
2019 53
2020 0
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2,603 results
Results by year
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Page 1
Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial.
Self WH, et al. Ann Emerg Med 2018. PMID 29753517 Free PMC article.
Prompt intravenous fluid therapy is a fundamental treatment for patients with septic shock. However, the optimal approach for administering intravenous fluid in septic shock resuscitation is unknown. ...The purpose of this article is to review the current literature on approaches to early fluid resuscitation in adults with septic shock and outline the rationale for the upcoming trial....
Prompt intravenous fluid therapy is a fundamental treatment for patients with septic shock. However, the optimal approa …
Rules of anti-infection therapy for sepsis and septic shock.
Zhou X, et al. Chin Med J (Engl) 2019 - Review. PMID 30807357 Free PMC article.
The successful control of infection is a key factor of resuscitation for sepsis and septic shock. This review examines evidence for the treatment of sepsis. ...CONCLUSIONS: This review highlights how to recognize and treat sepsis and septic shock and provides rules and a standard flowchart for anti-infection therapy for sepsis and septic shock for use in the clinical setting....
The successful control of infection is a key factor of resuscitation for sepsis and septic shock. This review examines evidenc …
Vasopressors for the Treatment of Septic Shock: Systematic Review and Meta-Analysis.
Avni T, et al. PLoS One 2015 - Review. PMID 26237037 Free PMC article.
We included randomized controlled trials comparing different vasopressors for the treatment of adult patients with septic shock. ...Norepinephrine should be regarded as the first line vasopressor in the treatment of septic shock....
We included randomized controlled trials comparing different vasopressors for the treatment of adult patients with septic shock
Corticosteroids in septic shock: a systematic review and network meta-analysis.
Gibbison B, et al. Crit Care 2017 - Review. PMID 28351429 Free PMC article.
The objective of this study was to elucidate any differences between the drugs and their treatment regimens regarding outcomes for corticosteroid use in adult patients with septic shock. ...CONCLUSIONS: There was no clear evidence that any one corticosteroid drug or treatment regimen is more likely to be effective in reducing mortality or reducing the incidence of gastrointestinal bleeding or superinfection in septic shock. ...
The objective of this study was to elucidate any differences between the drugs and their treatment regimens regarding outcomes for corticost …
Vitamin C: The next step in sepsis management?
Teng J, et al. J Crit Care 2018 - Review. PMID 28934705
Over the past decades, there has been a focus on the early identification and treatment of sepsis primarily with bundled and goal directed therapy. ...Emerging evidence provides cursory data in support of the administration of vitamin C in addition to standard therapy to ameliorate the effects of inflammation and improve hemodynamic stability in patients with sepsis and septic shock; however, further evidence is needed to support this practice. ...
Over the past decades, there has been a focus on the early identification and treatment of sepsis primarily with bundled and goal directed …
Low-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis.
Rygård SL, et al. Intensive Care Med 2018 - Review. PMID 29761216
PURPOSE: To assess the effect of low dose corticosteroids on outcomes in adults with septic shock. METHODS: We systematically reviewed randomised clinical trials (RCTs) comparing low-dose corticosteroids to placebo in adults with septic shock. ...CONCLUSIONS: In adults with septic shock treated with low dose corticosteroids, short- and longer-term mortality are unaffected, adverse events increase, but duration of shock, mechanical ventilation and ICU stay are reduced. ...
PURPOSE: To assess the effect of low dose corticosteroids on outcomes in adults with septic shock. METHODS: We systematically …
Early goal-directed and lactate-guided therapy in adult patients with severe sepsis and septic shock: a meta-analysis of randomized controlled trials.
Ding XF, et al. J Transl Med 2018. PMID 30486885 Free PMC article.
BACKGROUND: The ProCESS, ARISE, and ProMISe trials have failed to show that early goal-directed therapy (EGDT) reduces mortality in patients with severe sepsis and septic shock. ...LGT or usual care (UC) in adult patients with severe sepsis and septic shock. METHODS: Relevant randomized controlled trials published from January 1, 2001 to March 30, 2017 were identified in PubMed, EMBASE, Web of Science, and the Cochrane Library. ...
BACKGROUND: The ProCESS, ARISE, and ProMISe trials have failed to show that early goal-directed therapy (EGDT) reduces mortality in p …
Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis.
Kumar A, et al. Crit Care Med 2010 - Review. PMID 20639750
BACKGROUND: Septic shock represents the major cause of infection-associated mortality in the intensive care unit. The possibility that combination antibiotic therapy of bacterial septic shock improves outcome is controversial. ...CONCLUSION: Early combination antibiotic therapy is associated with decreased mortality in septic shock. Prospective randomized trials are needed....
BACKGROUND: Septic shock represents the major cause of infection-associated mortality in the intensive care unit. The possibil …
Pooled analysis of higher versus lower blood pressure targets for vasopressor therapy septic and vasodilatory shock.
Lamontagne F, et al. Intensive Care Med 2018. PMID 29260272
PURPOSE: Guidelines for shock recommend mean arterial pressure (MAP) targets for vasopressor therapy of at least 65 mmHg and, until recently, suggested that patients with underlying chronic hypertension and atherosclerosis may benefit from higher targets. ...METHODS: We searched the MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials for randomized controlled trials of higher versus lower blood pressure targets for vasopressor therapy in adult patients in shock (until November 2017). ...
PURPOSE: Guidelines for shock recommend mean arterial pressure (MAP) targets for vasopressor therapy of at least 65 mmHg and, …
Antimicrobial therapy in patients with septic shock.
Pastene B, et al. Presse Med 2016 - Review. PMID 27062114
Providing antibiotics is a life-saving intervention in patients with septic shock. Cultures as clinically appropriate before antimicrobial therapy are required. Guidelines recommend providing broad-spectrum antibiotics within the first hour after recognition of shock. The site of infection, the patient's history and clinical status, and the local ecology all affect the choice of empirical treatment. ...
Providing antibiotics is a life-saving intervention in patients with septic shock. Cultures as clinically appropriate before a …
2,603 results
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