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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 8
1966 26
1967 23
1968 26
1969 43
1970 33
1971 45
1972 37
1973 40
1974 40
1975 26
1976 38
1977 24
1978 41
1979 28
1980 34
1981 56
1982 42
1983 67
1984 54
1985 61
1986 42
1987 49
1988 39
1989 75
1990 65
1991 66
1992 55
1993 73
1994 63
1995 69
1996 71
1997 60
1998 75
1999 72
2000 88
2001 106
2002 101
2003 134
2004 138
2005 124
2006 157
2007 152
2008 149
2009 158
2010 148
2011 168
2012 158
2013 157
2014 172
2015 163
2016 144
2017 171
2018 145
2019 90
2020 0
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4,254 results
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Page 1
Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial.
Self WH, et al. Ann Emerg Med 2018. PMID 29753517 Free PMC article.
Prompt intravenous fluid therapy is a fundamental treatment for patients with septic shock. However, the optimal approach for administering intravenous fluid in septic shock resuscitation is unknown. ...The purpose of this article is to review the current literature on approaches to early fluid resuscitation in adults with septic shock and outline the rationale for the upcoming trial....
Prompt intravenous fluid therapy is a fundamental treatment for patients with septic shock. However, the optimal approa …
Rules of anti-infection therapy for sepsis and septic shock.
Zhou X, et al. Chin Med J (Engl) 2019 - Review. PMID 30807357 Free PMC article.
The successful control of infection is a key factor of resuscitation for sepsis and septic shock. This review examines evidence for the treatment of sepsis. ...CONCLUSIONS: This review highlights how to recognize and treat sepsis and septic shock and provides rules and a standard flowchart for anti-infection therapy for sepsis and septic shock for use in the clinical setting....
The successful control of infection is a key factor of resuscitation for sepsis and septic shock. This review examines evidenc …
Vitamin C: The next step in sepsis management?
Teng J, et al. J Crit Care 2018 - Review. PMID 28934705
Over the past decades, there has been a focus on the early identification and treatment of sepsis primarily with bundled and goal directed therapy. ...Emerging evidence provides cursory data in support of the administration of vitamin C in addition to standard therapy to ameliorate the effects of inflammation and improve hemodynamic stability in patients with sepsis and septic shock; however, further evidence is needed to support this practice. ...
Over the past decades, there has been a focus on the early identification and treatment of sepsis primarily with bundled and goal directed …
Low-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis.
Rygård SL, et al. Intensive Care Med 2018 - Review. PMID 29761216
PURPOSE: To assess the effect of low dose corticosteroids on outcomes in adults with septic shock. METHODS: We systematically reviewed randomised clinical trials (RCTs) comparing low-dose corticosteroids to placebo in adults with septic shock. ...CONCLUSIONS: In adults with septic shock treated with low dose corticosteroids, short- and longer-term mortality are unaffected, adverse events increase, but duration of shock, mechanical ventilation and ICU stay are reduced. ...
PURPOSE: To assess the effect of low dose corticosteroids on outcomes in adults with septic shock. METHODS: We systematically …
Antimicrobial therapy in patients with septic shock.
Pastene B, et al. Presse Med 2016 - Review. PMID 27062114
Providing antibiotics is a life-saving intervention in patients with septic shock. Cultures as clinically appropriate before antimicrobial therapy are required. Guidelines recommend providing broad-spectrum antibiotics within the first hour after recognition of shock. The site of infection, the patient's history and clinical status, and the local ecology all affect the choice of empirical treatment. ...
Providing antibiotics is a life-saving intervention in patients with septic shock. Cultures as clinically appropriate before a …
Pooled analysis of higher versus lower blood pressure targets for vasopressor therapy septic and vasodilatory shock.
Lamontagne F, et al. Intensive Care Med 2018. PMID 29260272
PURPOSE: Guidelines for shock recommend mean arterial pressure (MAP) targets for vasopressor therapy of at least 65 mmHg and, until recently, suggested that patients with underlying chronic hypertension and atherosclerosis may benefit from higher targets. ...METHODS: We searched the MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials for randomized controlled trials of higher versus lower blood pressure targets for vasopressor therapy in adult patients in shock (until November 2017). ...
PURPOSE: Guidelines for shock recommend mean arterial pressure (MAP) targets for vasopressor therapy of at least 65 mmHg and, …
The influence of esmolol on septic shock and sepsis: A meta-analysis of randomized controlled studies.
Liu P, et al. Am J Emerg Med 2018 - Review. PMID 29269160
BACKGROUND: Esmolol may have some potential in treating septic shock and sepsis. However, the results remain controversial. We conduct a systematic review and meta-analysis to explore the efficacy of esmolol in patients with septic shock and sepsis. ...CONCLUSIONS: Esmolol treatment may be able to improve survival rate, and reduce heart rate and TnI, but has no influence on MAP, CVP and ScvO2 in patients with septic shock and sepsis....
BACKGROUND: Esmolol may have some potential in treating septic shock and sepsis. However, the results remain controversial. We …
Hydrocortisone in Vasodilatory Shock.
Venkatesh B and Cohen J. Crit Care Clin 2019 - Review. PMID 30784608
Vasodilatory shock is the most common type of circulatory shock in critically ill patients; sepsis the predominant cause. Steroid use in septic shock gained favor in the 1970s; however, studies of high-dose steroids demonstrated excess morbidity and mortality. ...Two recent trials are likely to reinforce the role of steroids in septic shock and change the recommendation in future clinical practice guidelines. ...
Vasodilatory shock is the most common type of circulatory shock in critically ill patients; sepsis the predominant cause. Ster …
Optimizing antimicrobial therapy of sepsis and septic shock: focus on antibiotic combination therapy.
Vazquez-Grande G and Kumar A. Semin Respir Crit Care Med 2015 - Review. PMID 25643278
This review explores the pathophysiology of sepsis in an attempt to produce a better understanding and define key determinants of antimicrobial therapy response in septic shock. ...These meta-analyses did not undertake subgroup analyses of the septic shock population. This article reviews the existing evidence supporting combination therapy for severe infections, sepsis, and septic shock....
This review explores the pathophysiology of sepsis in an attempt to produce a better understanding and define key determinants of antimicrob …
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