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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 2
1967 3
1968 8
1969 8
1970 7
1971 9
1972 11
1973 13
1974 9
1975 7
1976 9
1977 6
1978 12
1979 7
1980 6
1981 10
1982 15
1983 15
1984 12
1985 18
1986 7
1987 9
1988 17
1989 27
1990 21
1991 31
1992 35
1993 38
1994 39
1995 37
1996 51
1997 34
1998 45
1999 44
2000 67
2001 56
2002 55
2003 71
2004 80
2005 72
2006 82
2007 103
2008 124
2009 83
2010 113
2011 132
2012 131
2013 138
2014 216
2015 202
2016 183
2017 216
2018 174
2019 68
2020 0
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2,753 results
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Page 1
Sepsis and septic shock.
Cecconi M, et al. Lancet 2018 - Review. PMID 29937192
Sepsis is a common condition that is associated with unacceptably high mortality and, for many of those who survive, long-term morbidity. ...
Sepsis is a common condition that is associated with unacceptably high mortality and, for many of those who survive, long-term morbid …
Severe Sepsis and Septic Shock Trials (ProCESS, ARISE, ProMISe): What is Optimal Resuscitation?
Osborn TM. Crit Care Clin 2017 - Review. PMID 28284298
Between 2014 and 2015, 3 independent, multicenter, randomized controlled trials evaluated early goal-directed therapy (EGDT) in severe sepsis and septic shock: Protocolized Care for Early Septic Shock (ProCESS) from the United States; Australasian Resuscitation in Sepsis Evaluation (ARISE), and Protocolised Management in Sepsis (ProMISe) in the United Kingdom. ...
Between 2014 and 2015, 3 independent, multicenter, randomized controlled trials evaluated early goal-directed therapy (EGDT) in severe sepsi …
Corticosteroids in septic shock: a systematic review and network meta-analysis.
Gibbison B, et al. Crit Care 2017 - Review. PMID 28351429 Free PMC article.
The objective of this study was to elucidate any differences between the drugs and their treatment regimens regarding outcomes for corticosteroid use in adult patients with septic shock. ...CONCLUSIONS: There was no clear evidence that any one corticosteroid drug or treatment regimen is more likely to be effective in reducing mortality or reducing the incidence of gastrointestinal bleeding or superinfection in septic shock. ...
The objective of this study was to elucidate any differences between the drugs and their treatment regimens regarding outcomes for corticost …
Goal-directed resuscitation for patients with early septic shock.
ARISE Investigators , et al. N Engl J Med 2014 - Clinical Trial. PMID 25272316 Free article.
BACKGROUND: Early goal-directed therapy (EGDT) has been endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to decrease mortality among patients presenting to the emergency department with septic shock. ...CONCLUSIONS: In critically ill patients presenting to the emergency department with early septic shock, EGDT did not reduce all-cause mortality at 90 days. ...
BACKGROUND: Early goal-directed therapy (EGDT) has been endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to dec …
Frequency and mortality of septic shock in Europe and North America: a systematic review and meta-analysis.
Vincent JL, et al. Crit Care 2019. PMID 31151462 Free PMC article.
Random effects meta-analyses were performed to estimate pooled frequency of septic shock diagnosed at admission and during the ICU stay and to estimate septic shock mortality in the ICU, hospital, and at 28 or 30 days. ...CONCLUSIONS: Our literature review reaffirms the continued common occurrence of septic shock and estimates a high mortality of around 38%. ...
Random effects meta-analyses were performed to estimate pooled frequency of septic shock diagnosed at admission and during the …
High versus low blood-pressure target in patients with septic shock.
Asfar P, et al. N Engl J Med 2014 - Clinical Trial. PMID 24635770 Free article.
BACKGROUND: The Surviving Sepsis Campaign recommends targeting a mean arterial pressure of at least 65 mm Hg during initial resuscitation of patients with septic shock. ...CONCLUSIONS: Targeting a mean arterial pressure of 80 to 85 mm Hg, as compared with 65 to 70 mm Hg, in patients with septic shock undergoing resuscitation did not result in significant differences in mortality at either 28 or 90 days. ...
BACKGROUND: The Surviving Sepsis Campaign recommends targeting a mean arterial pressure of at least 65 mm Hg during initial resuscitation of …
Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE.
Nguyen HB, et al. Crit Care 2016 - Review. PMID 27364620 Free PMC article.
Prior to 2001 there was no standard for early management of severe sepsis and septic shock in the emergency department. In the presence of standard or usual care, the prevailing mortality was over 40-50 %. ...Recently a trio of trials (ProCESS, ARISE, and ProMISe), while reporting an all-time low sepsis mortality, question the continued need for all of the elements of early goal-directed therapy or the need for protocolized care for patients with severe and septic shock. ...
Prior to 2001 there was no standard for early management of severe sepsis and septic shock in the emergency department. In the …
Severe Sepsis and Septic Shock: Timing of Septic Shock Onset Matters.
Huang CT, et al. Shock 2016. PMID 26717110
The primary outcome of interest was the impact of timing of septic shock onset on in-hospital mortality. We also sought to identify potential factors predicting development of septic shock after ICU admission. ...Timing of onset of septic shock was an independent predictor of in-hospital outcome, and there was an increasing trend of in-hospital mortality with later onset of septic shock. ...
The primary outcome of interest was the impact of timing of septic shock onset on in-hospital mortality. We also sought …
Blood Purification and Mortality in Sepsis and Septic Shock: A Systematic Review and Meta-analysis of Randomized Trials.
Putzu A, et al. Anesthesiology 2019. PMID 31246600
BACKGROUND: Sepsis and septic shock are severe inflammatory conditions related to high morbidity and mortality. We performed a systematic review with meta-analysis of randomized trials to assess whether extracorporeal blood purification reduces mortality in this setting. ...CONCLUSIONS: Very low-quality randomized evidence demonstrates that the use of hemoperfusion, hemofiltration, or plasmapheresis may reduce mortality in sepsis or septic shock. ...
BACKGROUND: Sepsis and septic shock are severe inflammatory conditions related to high morbidity and mortality. We perf …
The controversial role of corticosteroids in septic shock.
Pourmand A, et al. Am J Emerg Med 2019 - Review. PMID 31056383
In this review, we discuss recent studies evaluating the impact of corticosteroids on morbidity and mortality in septic shock and explore future directions to fully elucidate when and how the administration of corticosteroid therapies can be beneficial. ...CONCLUSIONS: There remains a need for improved therapy for patients in septic shock. Corticosteroids have shown some potential in improving mortality rates and clinical markers. ...
In this review, we discuss recent studies evaluating the impact of corticosteroids on morbidity and mortality in septic sho
2,753 results
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