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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1956 3
1957 7
1958 5
1959 6
1965 10
1966 31
1967 75
1968 163
1969 170
1970 169
1971 208
1972 266
1973 263
1974 240
1975 201
1976 194
1977 228
1978 277
1979 286
1980 327
1981 316
1982 433
1983 455
1984 427
1985 431
1986 398
1987 303
1988 348
1989 503
1990 742
1991 891
1992 985
1993 1196
1994 1275
1995 1361
1996 1390
1997 1513
1998 1785
1999 2033
2000 2693
2001 2994
2002 3413
2003 3526
2004 3825
2005 4167
2006 4623
2007 5689
2008 6342
2009 6558
2010 7319
2011 7931
2012 9018
2013 9505
2014 9792
2015 10935
2016 11176
2017 11195
2018 11230
2019 5231
2020 78
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140,147 results
Results by year
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Page 1
WNT Signaling in Cardiac and Vascular Disease
Foulquier S, et al. Pharmacol Rev 2018 - Review. PMID 29247129 Free PMC article.
WNT signaling is an elaborate and complex collection of signal transduction pathways mediated by multiple signaling molecules. ...
WNT signaling is an elaborate and complex collection of signal transduction pathways mediated by multiple signaling molecules. …
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
Takebe N, et al. Nat Rev Clin Oncol 2015 - Review. PMID 25850553 Free PMC article.
CSCs display many features of embryonic or tissue stem cells, and typically demonstrate persistent activation of one or more highly conserved signal transduction pathways involved in development and tissue homeostasis, including the Notch, Hedgehog (HH), and Wnt pathways. ...
CSCs display many features of embryonic or tissue stem cells, and typically demonstrate persistent activation of one or more highly conserve …
Targeting G protein-coupled receptor signalling by blocking G proteins
Campbell AP and Smrcka AV. Nat Rev Drug Discov 2018 - Review. PMID 30262890 Free PMC article.
G protein-coupled receptors (GPCRs) are the largest class of drug targets, largely owing to their druggability, diversity and physiological efficacy. ...
G protein-coupled receptors (GPCRs) are the largest class of drug targets, largely owing to their druggability, diversity and physiol …
Potential mechanisms of action of lithium in bipolar disorder. Current understanding
Malhi GS, et al. CNS Drugs 2013 - Review. PMID 23371914
For instance, the effects of lithium on the adenyl cyclase and phospho-inositide pathways, as well as protein kinase C, may serve to dampen excessive excitatory neurotransmission. In addition to these many putative mechanisms, it has also been proposed that the neuroprotective effects of lithium are key to its therapeutic actions. ...
For instance, the effects of lithium on the adenyl cyclase and phospho-inositide pathways, as well as protein kinase C, may serve to …
C-type Lectin Receptor: Old Friend and New Player
Hou H, et al. Med Chem 2017 - Review. PMID 28494724
Upon stimulation, CLRs induce multiple signal transduction cascades through their own immunereceptor tyrosine-based activation motifs (ITAMs) or interacting with ITAM-containing adaptor proteins such as FcRγ, which then lead to the activation of nuclear factor kappa B (NF-κB) through Syk- and CARD9-dependent pathway. Dissecting CLR signal cascades and their effects on host immune cells is essential to understand the molecular mechanisms in regulating host antifungal immunity. ...
Upon stimulation, CLRs induce multiple signal transduction cascades through their own immunereceptor tyrosine-based activation …
Emergence of TNIK inhibitors in cancer therapeutics
Yamada T and Masuda M. Cancer Sci 2017 - Review. PMID 28208209 Free PMC article.
To improve patient prognosis, it will be necessary to identify new drug targets based on molecules that are essential for colorectal carcinogenesis, and to develop therapeutics that target such molecules. ...Several small-molecule compounds targeting this protein kinase have been shown to have anti-tumor effects against various cancers. ...
To improve patient prognosis, it will be necessary to identify new drug targets based on molecules that are essential for colorectal …
Preface
Shukla AK. Eur J Pharmacol 2015. PMID 26407629
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