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375 results

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Page 1
The Skin Sensitisation of Cosmetic Ingredients: Review of Actual Regulatory Status.
Bialas I, Zelent-Kraciuk S, Jurowski K. Bialas I, et al. Toxics. 2023 Apr 21;11(4):392. doi: 10.3390/toxics11040392. Toxics. 2023. PMID: 37112619 Free PMC article. Review.
Thus, the EU cosmetics legislation requires skin sensitisation assessment for all cosmetics ingredients, including the regulated ones (for which the full toxicological dossier needs to be analysed by the Scientific Committee on Consumer Safety (SCCS)) and those (per …
Thus, the EU cosmetics legislation requires skin sensitisation assessment for all cosmetics ingredients, including the regulat …
Propylene glycol, skin sensitisation and allergic contact dermatitis: A scientific and regulatory conundrum.
Pemberton MA, Kimber I. Pemberton MA, et al. Regul Toxicol Pharmacol. 2023 Feb;138:105341. doi: 10.1016/j.yrtph.2023.105341. Epub 2023 Jan 23. Regul Toxicol Pharmacol. 2023. PMID: 36702195 Free article. Review.
PG is not classified as hazardous under the Globally Harmonised System of Classification and Labelling of Chemicals (GHS) but poses an intriguing scientific and regulatory conundrum with respect to allergic contact dermatitis (ACD), the uncertainty being whether and to what exten …
PG is not classified as hazardous under the Globally Harmonised System of Classification and Labelling of Chemicals (GHS) but poses an intri …
Are skin sensitisation test methods relevant for proteins?
Basketter DA, Kimber I. Basketter DA, et al. Regul Toxicol Pharmacol. 2018 Nov;99:244-248. doi: 10.1016/j.yrtph.2018.09.028. Epub 2018 Sep 27. Regul Toxicol Pharmacol. 2018. PMID: 30268830 Review.
Tests for identification of chemical skin sensitisation hazard have been available for decades, evolving from guinea pig assays, through the first validated method, the local lymph node assay, to several validated in vitro methods. ...However, the absence of any spe …
Tests for identification of chemical skin sensitisation hazard have been available for decades, evolving from guinea pig assay …
Skin sensitisation, adverse outcome pathways and alternatives.
Basketter D. Basketter D. Altern Lab Anim. 2016 Oct;44(5):431-436. doi: 10.1177/026119291604400501. Altern Lab Anim. 2016. PMID: 27805825 Review.
For toxicologists who are in any way associated with skin sensitisation, the last two decades have seen a series of fundamental changes. We have migrated from old-style guinea-pig assays, via the refined and reduced Local Lymph Node Assay (LLNA), to witness the immi …
For toxicologists who are in any way associated with skin sensitisation, the last two decades have seen a series of fundamenta …
The activity of methacrylate esters in skin sensitisation test methods: A review.
Kimber I. Kimber I. Regul Toxicol Pharmacol. 2019 Jun;104:14-20. doi: 10.1016/j.yrtph.2019.02.014. Epub 2019 Feb 28. Regul Toxicol Pharmacol. 2019. PMID: 30826317 Free article. Review.
Skin sensitisation associated with allergic contact dermatitis is an important occupational and environmental disease. The identification of skin sensitisation hazards was traditionally performed using animal tests; originally guinea pig assays and sub …
Skin sensitisation associated with allergic contact dermatitis is an important occupational and environmental disease. The ide …
Skin sensitisation testing--new perspectives and recommendations.
Steiling W, Basketter D, Berthold K, Butler M, Garrigue JL, Kimber I, Lea L, Newsome C, Roggeband R, Stropp G, Waterman S, Wiemann C. Steiling W, et al. Food Chem Toxicol. 2001 Apr;39(4):293-301. doi: 10.1016/s0278-6915(00)00147-2. Food Chem Toxicol. 2001. PMID: 11295477 Review.
Various methodological aspects of skin sensitisation testing have been explored, particularly in the context of animal welfare considerations and reliability and sensitivity of test methods. Recommendations are made for the conduct of current and proposed OECD sk …
Various methodological aspects of skin sensitisation testing have been explored, particularly in the context of animal welfare …
Devising a Tier-based Skin Sensitisation Screening Strategy for Personal Care and Cosmetic Products.
Fung ES, Towle KM, Monnot AD. Fung ES, et al. Altern Lab Anim. 2020 Mar;48(2):70-77. doi: 10.1177/0261192920924401. Epub 2020 May 22. Altern Lab Anim. 2020. PMID: 32441989 Review.
The goal of this study was to develop a proof-of-concept tier-based screening strategy for the assessment of skin sensitisation potential by using non-animal methodologies. As a case example, this screening framework was applied to three WEN by Chaz Dean cleansing c …
The goal of this study was to develop a proof-of-concept tier-based screening strategy for the assessment of skin sensitisation …
Standardisation and international adoption of defined approaches for skin sensitisation.
Casati S, Asturiol D, Browne P, Kleinstreuer N, Régimbald-Krnel M, Therriault P. Casati S, et al. Front Toxicol. 2022 Aug 11;4:943152. doi: 10.3389/ftox.2022.943152. eCollection 2022. Front Toxicol. 2022. PMID: 36032790 Free PMC article. Review.
In the absence of stand-alone one-to-one replacements for existing animal tests, efforts were made to integrate data from in silico, in chemico and in vitro methods to ensure sufficient mechanistic coverage of the skin sensitisation Adverse Outcome Pathway (AOP) and …
In the absence of stand-alone one-to-one replacements for existing animal tests, efforts were made to integrate data from in silico, in chem …
Skin sensitisation.
Basketter D, Casati S, Gerberick GF, Griem P, Philips B, Worth A. Basketter D, et al. Altern Lab Anim. 2005 Jul;33 Suppl 1:83-103. doi: 10.1177/026119290503301s10. Altern Lab Anim. 2005. PMID: 16194142 No abstract available.
375 results