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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 1
1993 12
1994 24
1995 26
1996 32
1997 25
1998 23
1999 21
2000 19
2001 23
2002 21
2003 22
2004 28
2005 33
2006 32
2007 37
2008 43
2009 48
2010 40
2011 42
2012 46
2013 64
2014 52
2015 56
2016 48
2017 40
2018 45
2019 22
2020 0
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852 results
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Page 1
Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial.
Jaber S, et al. Lancet 2018 - Clinical Trial. PMID 29910040 Free article.
Therefore, we aimed to evaluate whether sodium bicarbonate infusion would improve these outcomes in critically ill patients. ...We randomly assigned patients (1:1), by stratified randomisation with minimisation via a restricted web platform, to receive either no sodium bicarbonate (control group) or 4·2% of intravenous sodium bicarbonate infusion (bicarbonate group) to maintain the arterial pH above 7·30. ...
Therefore, we aimed to evaluate whether sodium bicarbonate infusion would improve these outcomes in critically ill patients. . …
Sodium bicarbonate therapy in patients with metabolic acidosis.
Adeva-Andany MM, et al. ScientificWorldJournal 2014 - Review. PMID 25405229 Free PMC article.
Replacement of sodium bicarbonate to patients with sodium bicarbonate loss due to diarrhea or renal proximal tubular acidosis is useful, but there is no definite evidence that sodium bicarbonate administration to patients with acute metabolic acidosis, including diabetic ketoacidosis, lactic acidosis, septic shock, intraoperative metabolic acidosis, or cardiac arrest, is beneficial regarding clinical outcomes or mortality rate. ...Sodium bicarbonate is the predominant buffer used in dialysis fluids and patients on maintenance dialysis are subjected to a load of sodium bicarbonate during the sessions, suffering a transient metabolic alkalosis of variable severity. ...
Replacement of sodium bicarbonate to patients with sodium bicarbonate loss due to diarrhea or renal proximal tub …
Sodium bicarbonate: A review and its uses in dentistry.
Madeswaran S and Jayachandran S. Indian J Dent Res 2018 - Review. PMID 30409952 Free article.
Sodium bicarbonate, the common baking soda, has been reported to be versatile. A search of the resources through Medline and Google Scholar was made to understand the current status of the mouth rinses and the use of sodium bicarbonate. ...
Sodium bicarbonate, the common baking soda, has been reported to be versatile. A search of the resources through Medline and G
Uses and misuses of sodium bicarbonate in the neonatal intensive care unit.
Collins A and Sahni R. Semin Fetal Neonatal Med 2017 - Review. PMID 28801177
Clinicians often feel compelled to use bicarbonate since acidosis implies a need for such therapy and thus the justification for its use is based on hearsay rather than science. This review summarizes the evidence and refutes the clinical practice of administering sodium bicarbonate to treat metabolic acidosis associated with several specific clinical syndromes in neonates....
Clinicians often feel compelled to use bicarbonate since acidosis implies a need for such therapy and thus the justification f …
Sodium bicarbonate for the treatment of lactic acidosis.
Forsythe SM and Schmidt GA. Chest 2000 - Review. PMID 10631227
Can sodium bicarbonate raise the pH in vivo? Does increasing the blood pH with sodium bicarbonate have any salutary effects? Does sodium bicarbonate have negative side effects? We find that the oft-cited rationale for bicarbonate use, that it might ameliorate the hemodynamic depression of metabolic acidemia, has been disproved convincingly. ...
Can sodium bicarbonate raise the pH in vivo? Does increasing the blood pH with sodium bicarbonate have any salut …
Non-traumatic rhabdomyolysis: Background, laboratory features, and acute clinical management
Cervellin G, et al. Clin Biochem 2017 - Review. PMID 28235546
The essential clinical management in the emergency department is based on a targeted intervention to manage the underlying cause, combined with infusion of fluids and eventually sodium bicarbonate. ...
The essential clinical management in the emergency department is based on a targeted intervention to manage the underlying cause, combined w …
Effectiveness of sodium bicarbonate infusion on mortality in septic patients with metabolic acidosis.
Zhang Z, et al. Intensive Care Med 2018. PMID 30255318
OBJECTIVE: Although sodium bicarbonate (SB) solution has been widely used in clinical practice, its effect on mortality when administered to a large population of patients with acidosis is not known. ...Both pH [7.16 (standard deviation (SD): 0.10) vs. 7.22 (SD: 0.07); p < 0.001] and bicarbonate concentration (BC) [11.84 (SD: 3.63) vs. 14.88 (SD: 3.36) mmol/l; p < 0.001] were significantly lower in the SB than that in the non-SB group. ...
OBJECTIVE: Although sodium bicarbonate (SB) solution has been widely used in clinical practice, its effect on mortality when a …
Sodium bicarbonate use in shock and cardiac arrest: attitudes of pediatric acute care physicians.
Parker MJ and Parshuram CS. Crit Care Med 2013. PMID 23760153
Both pH and duration of resuscitation were strongly associated with the decision to administer sodium bicarbonate (p<0.0001). Respondents' perceptions regarding a colleague's likelihood of administering sodium bicarbonate to the same patient under the same circumstances reflect an acknowledgment of disparate practices with respect to sodium bicarbonate use. 53.0% (79/149) felt current American Heart Association guidelines help them in deciding whether to administer sodium bicarbonate to critically ill patients, and 84% would support a randomized trial. ...
Both pH and duration of resuscitation were strongly associated with the decision to administer sodium bicarbonate (p<0.0001 …
[Correlation between the use of sodium bicarbonate and intraventricular hemorrhage in preterms].
García-Pasquel MJ, et al. Rev Med Inst Mex Seguro Soc 2015. PMID 26177440 Spanish.
The use of sodium bicarbonate has been linked to the presence of IVH. The main purpose of this study was to determine if the infusion of sodium bicarbonate during the first 24 hours increases the risk of IVH in preterm infants. METHODS: Our study is a cohort; we analyzed the files of 160 patients and divided them into two groups: one in which sodium bicarbonate was not used and another in which it was; this latter group was subdivided into two considering if the use was therapeutic of prophylactic. ...
The use of sodium bicarbonate has been linked to the presence of IVH. The main purpose of this study was to determine i …
Sodium bicarbonate use during in-hospital pediatric pulseless cardiac arrest - a report from the American Heart Association Get With The Guidelines(®)-Resuscitation.
Raymond TT, et al. Resuscitation 2015. PMID 25613362 Free PMC article.
BACKGROUND: Despite limited recommendations for using sodium bicarbonate (SB) during cardiopulmonary resuscitation (CPR), we hypothesized that SB continues to be used frequently during pediatric in-hospital cardiac arrest (IHCA) and that its use varies by hospital-specific, patient-specific, and event-specific characteristics. ...Multivariable logistic regression analyzed the association between SB use and outcomes. SB had increased use an ICU location, metabolic/electrolyte disturbance, prolonged CPR, pVT/VF, and concurrently with other pharmacologic interventions. ...
BACKGROUND: Despite limited recommendations for using sodium bicarbonate (SB) during cardiopulmonary resuscitation (CPR), we h …
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