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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 8
1946 19
1947 37
1948 33
1949 23
1950 31
1951 31
1952 36
1953 27
1954 38
1955 16
1956 38
1957 41
1958 40
1959 37
1960 39
1961 34
1962 47
1963 72
1964 134
1965 178
1966 214
1967 378
1968 715
1969 875
1970 792
1971 952
1972 1129
1973 1360
1974 1476
1975 1083
1976 995
1977 993
1978 954
1979 949
1980 868
1981 831
1982 832
1983 983
1984 1051
1985 1198
1986 1147
1987 958
1988 960
1989 1137
1990 1257
1991 1166
1992 1085
1993 1130
1994 1271
1995 1195
1996 1221
1997 1250
1998 1460
1999 1712
2000 1744
2001 2029
2002 2215
2003 2119
2004 2305
2005 2655
2006 2944
2007 3229
2008 3454
2009 3207
2010 3494
2011 3740
2012 3909
2013 3662
2014 3468
2015 3499
2016 3343
2017 3216
2018 2974
2019 1772
2020 65
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87,944 results
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Page 1
ATP as a biological hydrotrope
Patel A, et al. Science 2017. PMID 28522535
Amyloid Fibril Solubility.
Rizzi LG and Auer S. J Phys Chem B 2015. PMID 26496385 Free article.
It is well established that amyloid fibril solubility is protein specific, but how solubility depends on the interactions between the fibril building blocks is not clear. ...Our simulations confirms that the fibril solubility depends on the fibril thickness and that the relationship between the interactions and the solubility can be described by a simple analytical formula. ...
It is well established that amyloid fibril solubility is protein specific, but how solubility depends on the interactions betw …
Solubility product challenge.
Michałowska-Kaczmarczyk AM and Michałowski T. Anal Bioanal Chem 2015. PMID 25700545
Peptide Solubility Limits: Backbone and Side-Chain Interactions.
Sarma R, et al. J Phys Chem B 2018. PMID 29384681 Free PMC article.
We calculate the solubility limit of pentapeptides in water by simulating the phase separation in an oversaturated aqueous solution. ...We also demonstrate that fluctuations in conformation and hydration number of peptide in monomeric form are correlated with the solubility of the peptide. ...
We calculate the solubility limit of pentapeptides in water by simulating the phase separation in an oversaturated aqueous solution. …
Crystal Engineering for Enhanced Solubility and Bioavailability of Poorly Soluble Drugs.
Varshosaz J, et al. Curr Pharm Des 2018 - Review. PMID 29998799
Researchers of pharmaceutical sciences have used this knowledge to alter the structure of crystalline medications in order to remedy the problems of more than 40% of the new designed drugs which suffer from low solubility and consequently, low bioavailability which have limited their clinical application. METHODS: This review covers a broad spectrum of aspects of the application of crystal engineering in pharmaceutics and includes a comprehensive wide range of different techniques used in crystal engineering of active pharmaceutical ingredients (API) to compensate the low water solubility and bioavailability of drugs related specially to class II of biopharmaceutical classification system (BCS). ...
Researchers of pharmaceutical sciences have used this knowledge to alter the structure of crystalline medications in order to remedy the pro …
Selecting and engineering monoclonal antibodies with drug-like specificity
Starr CG and Tessier PM. Curr Opin Biotechnol 2019 - Review. PMID 30822699 Free PMC article.
We argue that one of the most important and underappreciated drug-like antibody properties is high specificity - defined here as low levels of antibody non-specific and self-interactions - which is linked to low off-target binding and slow antibody clearance in vivo and high solubility and low viscosity in vitro. ...
We argue that one of the most important and underappreciated drug-like antibody properties is high specificity - defined here as low levels …
Evaluation of Accuracy of Amorphous Solubility Advantage Calculation by Comparison with Experimental Solubility Measurement in Buffer and Biorelevant Media.
Zhang W, et al. Mol Pharm 2018. PMID 29522344
The accuracy of amorphous solubility advantage calculation was evaluated by experimental solubility measurement. Ten structurally diverse compounds were studied to test the generlity of the theoretical calculation. ...By direct dissolution, the effect of different preparation methods on amorphous solubility was also studied. Finally, solubility measurement was performed in fasted state simulated intestinal fluid (FaSSIF) to assess the effect of bile salt on the concentration-based amorphous solubility advantage. ...
The accuracy of amorphous solubility advantage calculation was evaluated by experimental solubility measurement. Ten structura …
Ion Specificity and Nonmonotonic Protein Solubility from Salt Entropy.
Dahal YR and Schmit JD. Biophys J 2018. PMID 29320698 Free PMC article.
The addition of salt to protein solutions can either increase or decrease the protein solubility, and the magnitude of this effect depends on the salt used. ...We find that the ion radius has significant effects on the translational entropy of the salt, which leads to salt specificity in the protein solubility. ...
The addition of salt to protein solutions can either increase or decrease the protein solubility, and the magnitude of this effect de …
Natural Deep Eutectic Solvents: Properties, Applications, and Perspectives
Liu Y, et al. J Nat Prod 2018 - Review. PMID 29513526 Free PMC article.
As functional liquid media, natural deep eutectic solvent (NADES) species can dissolve natural or synthetic chemicals of low water solubility. ...
As functional liquid media, natural deep eutectic solvent (NADES) species can dissolve natural or synthetic chemicals of low water solubi
87,944 results
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