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1991 1
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1998 15
1999 10
2000 13
2001 10
2002 9
2003 10
2004 8
2005 12
2006 8
2007 5
2008 6
2009 10
2010 5
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239 results
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Page 1
Natural RNA circles function as efficient microRNA sponges
Hansen TB, et al. Nature 2013. PMID 23446346
Here we show that this circRNA acts as a miR-7 sponge; we term this circular transcript ciRS-7 (circular RNA sponge for miR-7). ciRS-7 contains more than 70 selectively conserved miRNA target sites, and it is highly and widely associated with Argonaute (AGO) proteins in a miR-7-dependent manner. ...We further show that the testis-specific circRNA, sex-determining region Y (Sry), serves as a miR-138 sponge, suggesting that miRNA sponge effects achieved by circRNA formation are a general phenomenon. ...
Here we show that this circRNA acts as a miR-7 sponge; we term this circular transcript ciRS-7 (circular RNA sponge for miR-7). ciRS-7 conta …
NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY.
Thevenet L, et al. J Biol Chem 2005. PMID 16166090 Free article.
The morphological effects of SRY are well documented; however, its molecular mechanism of action remains unknown. Moreover, SRY proteins display high sequence variability among mammalian species, which makes protein motifs difficult to delineate. We previously isolated SIP-1/NHERF2 as a human SRY-interacting protein. SIP-1/NHERF2, a PDZ protein, interacts with the C-terminal extremity of the human SRY protein. ...
The morphological effects of SRY are well documented; however, its molecular mechanism of action remains unknown. Moreover, SRY
Circular transcripts of the testis-determining gene Sry in adult mouse testis.
Capel B, et al. Cell 1993. PMID 7684656
Sry is expressed at higher levels in the adult testis, where no function has been determined, than in the genital ridge, its critical site of action. cDNA and 5' RACE clones isolated from testis or from Sry-transfected cell lines have an unusual structure, with 3' sequences located in a 5' position. ...Furthermore, oligonucleotide hybridization and RNAase H digestion proved that these Sry RNA molecules are circular. Similar transcripts were detected in the testes of mice with Mus musculus musculus, Mus musculus domesticus, and Mus spretus Sry genes. ...
Sry is expressed at higher levels in the adult testis, where no function has been determined, than in the genital ridge, its critical
Structure-function analysis of mouse Sry reveals dual essential roles of the C-terminal polyglutamine tract in sex determination.
Zhao L, et al. Proc Natl Acad Sci U S A 2014. PMID 25074915 Free PMC article.
Mouse Sry is unusual in that it includes a C-terminal polyglutamine (polyQ) tract that is absent in nonrodent SRY proteins, and yet, paradoxically, is essential for male sex determination. ...Sry protein lacking the polyQ domain was unstable, due to proteasomal degradation. Replacing this domain with irrelevant sequences stabilized the protein but failed to restore Sry's ability to up-regulate its key target gene SRY-box 9 (Sox9) and its sex-determining function in vivo. ...
Mouse Sry is unusual in that it includes a C-terminal polyglutamine (polyQ) tract that is absent in nonrodent SRY proteins
The human SRY protein is present in fetal and adult Sertoli cells and germ cells.
Salas-Cortés L, et al. Int J Dev Biol 1999. PMID 10235389 Free article.
To localize the SRY protein and determine its cellular distribution, we prepared monoclonal antibodies (mAb) against the recombinant SRY protein. ...In addition two 46,XX SRY(+) males had the SRY protein in their gonadal tissues. All other samples were negative, including all female tissue studied and the testis of a 46,XX SRY(-) male. ...
To localize the SRY protein and determine its cellular distribution, we prepared monoclonal antibodies (mAb) against the recom …
Expression of SRY proteins in both normal and sex-reversed XY fetal mouse gonads.
Taketo T, et al. Dev Dyn 2005. PMID 15789443 Free article.
Sry encodes a protein with a DNA-binding domain and probably acts as a transcription factor. However, the mode of SRY action in testis determination remains largely unknown. ...The tissue-specificity and ontogeny of the detected protein were consistent with those of Sry transcripts. Immunofluorescent double labeling revealed that the SRY protein was detected in the Sertoli cell lineage and was swiftly down-regulated concurrently with testis cord organization. ...
Sry encodes a protein with a DNA-binding domain and probably acts as a transcription factor. However, the mode of SRY a
Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.
Peng H, et al. J Biol Chem 2009. PMID 19850934 Free PMC article.
Recently a KRAB domain protein (KRAB-O) that lacks a zinc finger motif has been demonstrated to interact with SRY and hypothesized to function as an adaptor molecule for SRY by tethering the KAP1-NuRD-SETDB1-HP1 silencing machinery to repress SRY targets. ...These results suggest that SRY has co-opted the KRAB-O protein to recruit the KAP1 repression machinery to sex determination target genes. ...
Recently a KRAB domain protein (KRAB-O) that lacks a zinc finger motif has been demonstrated to interact with SRY and hypothes …
Sry-Independent Overexpression of Sox9 Supports Spermatogenesis and Fertility in the Mouse.
Ortega EA, et al. Biol Reprod 2015. PMID 26536904 Free PMC article.
Sox9 is an autosomal gene and a primary downstream target of SRY. The activation of Sox9 in the absence of Sry is sufficient for initiation of male-specific sex determination. ...We examined males with the Y chromosome carrying a deletion removing the endogenous Sry, with testes determination driven either by the Sox9 (XY(Tdym1)Sox9) or the Sry (XY(Tdym1)Sry) transgenes as well as wild-type males (XY). ...
Sox9 is an autosomal gene and a primary downstream target of SRY. The activation of Sox9 in the absence of Sry is sufficient f …
Loss of p300 and CBP disrupts histone acetylation at the mouse Sry promoter and causes XY gonadal sex reversal.
Carré GA, et al. Hum Mol Genet 2018. PMID 29145650 Free PMC article.
CREB-binding protein (CBP, CREBBP, KAT3A) and its closely related paralogue p300 (EP300, KAT3B), together termed p300/CBP, are histone/lysine acetyl-transferases that control gene expression by modifying chromatin-associated proteins. ...Our data suggest a role for CBP/p300 in testis determination mediated by control of histone acetylation at the Sry locus and reveal a novel element in the epigenetic control of Sry and mammalian sex determination. ...
CREB-binding protein (CBP, CREBBP, KAT3A) and its closely related paralogue p300 (EP300, KAT3B), together termed p300/CBP, are histon …
CRISPR/Cas9-mediated knock-in of the murine Y chromosomal Sry gene.
Imaimatsu K, et al. J Reprod Dev 2018. PMID 29657232 Free PMC article.
This system allows for the production of loss-of-function mutations in various Y chromosome genes, including Sry, in mice. Here, we report the establishment of a CRISPR-Cas9-mediated knock-in line of Flag-tag sequences into the Sry locus at the C-terminal coding end of the Y chromosome (Y(Sry-flag)). ...To our knowledge, this study is the first to produce a stable Sry knock-in line at the C-terminal region, highlighting a novel approach for examining the significance of amino acid changes at the naive Sry locus in mammals....
This system allows for the production of loss-of-function mutations in various Y chromosome genes, including Sry, in mice. Here, we r …
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