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Evaluation of the new photosensitizer Stakel (WST-11) for photodynamic choroidal vessel occlusion in rabbit and rat eyes.
Berdugo M, Bejjani RA, Valamanesh F, Savoldelli M, Jeanny JC, Blanc D, Ficheux H, Scherz A, Salomon Y, BenEzra D, Behar-Cohen F. Berdugo M, et al. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1633-44. doi: 10.1167/iovs.07-0767. Invest Ophthalmol Vis Sci. 2008. PMID: 18385085
PURPOSE: To evaluate the photodynamic potential of a new hydrosoluble photosensitizer (WST-11, Stakel; Steba Biotech, Toussus-Le-Noble, France), for use in occlusion of normal choroidal vessels in the rabbit eye and CNV (choroidal neovascularization) in the r …
PURPOSE: To evaluate the photodynamic potential of a new hydrosoluble photosensitizer (WST-11, Stakel; Steba Biotech, T …
Treatment of localized prostate cancer using WST-09 and WST-11 mediated vascular targeted photodynamic therapy-A review.
Kawczyk-Krupka A, Wawrzyniec K, Musiol SK, Potempa M, Bugaj AM, Sieroń A. Kawczyk-Krupka A, et al. Photodiagnosis Photodyn Ther. 2015 Dec;12(4):567-74. doi: 10.1016/j.pdpdt.2015.10.001. Epub 2015 Oct 20. Photodiagnosis Photodyn Ther. 2015. PMID: 26467273 Review.
A brief general overview of focal prostate cancer therapy was provided, followed by a discussion of both basic and clinical research pertaining to prostate cancer VTP, with a focus on the palladium-based WST-09 and WST-11 photosensitisers. MATERIALS AND METHO …
A brief general overview of focal prostate cancer therapy was provided, followed by a discussion of both basic and clinical research pertain …
Bombesin Antagonist-Based Radiotherapy of Prostate Cancer Combined with WST-11 Vascular Targeted Photodynamic Therapy.
Kim K, Zhang H, La Rosa S, Jebiwott S, Desai P, Kimm S, Scherz A, O'Donoghue JA, Weber WA, Coleman JA. Kim K, et al. Clin Cancer Res. 2017 Jul 1;23(13):3343-3351. doi: 10.1158/1078-0432.CCR-16-2745. Epub 2017 Jan 20. Clin Cancer Res. 2017. PMID: 28108545 Free PMC article.
This therapeutic potential is limited by the fast washout of the conjugates from the target tumors. WST-11 (Weizmann STeba-11 drug; a negatively charged water-soluble palladium-bacteriochlorophyll derivative, Tookad Soluble) vascular targeted photodynamic the …
This therapeutic potential is limited by the fast washout of the conjugates from the target tumors. WST-11 (Weizmann STeba- …
Final Results of a Phase I Trial of WST-11 (TOOKAD Soluble) Vascular-Targeted Photodynamic Therapy for Upper Tract Urothelial Carcinoma.
Yip W, Sjoberg DD, Nogueira LM, Tracey AT, Alvim RG, Reisz PA, Demac Q, Benfante NE, Vanden Berg RW, Kim K, Al-Ahmadie H, Lin O, Bochner BH, Dalbagni G, Donat SM, Pietzak EJ, Hakimi AA, Solit DB, Scherz A, Bajorin DF, Coleman JA. Yip W, et al. J Urol. 2023 Feb 1:101097JU0000000000003202. doi: 10.1097/JU.0000000000003202. Online ahead of print. J Urol. 2023. PMID: 36724067
This phase I trial (NCT03617003) evaluated the safety of VTP with WST-11 in UTUC. MATERIALS AND METHODS: Nineteen patients underwent up to 2 endoscopic VTP treatments, with follow-up for up to 6 months. ...No ureteral strictures associated with treatment were identi …
This phase I trial (NCT03617003) evaluated the safety of VTP with WST-11 in UTUC. MATERIALS AND METHODS: Nineteen patients und …
Evaluating swallowing dysfunction using a 100-ml water swallowing test.
Wu MC, Chang YC, Wang TG, Lin LC. Wu MC, et al. Dysphagia. 2004 Winter;19(1):43-7. doi: 10.1007/s00455-003-0030-x. Dysphagia. 2004. PMID: 14745645 Clinical Trial.
Each subject underwent a 100-ml WST followed by VFES. Data was obtained on swallowing speed and signs of choking (coughing and a wet-hoarse voice). ...Among the ten participants with normal swallowing speed (> 10 ml/s), eight were diagnosed with dysphagia by VFES. Notab …
Each subject underwent a 100-ml WST followed by VFES. Data was obtained on swallowing speed and signs of choking (coughing and a wet- …
The effect of bacteriochlorophyll derivative WST-D and near infrared light on the molecular and fibrillar architecture of the corneal stroma.
Hayes S, Aldahlawi N, Marcovich AL, Brekelmans J, Goz A, Scherz A, Young RD, Bell JS, O'Brart DP, Nuijts RMMA, Meek KM. Hayes S, et al. Sci Rep. 2020 Jun 17;10(1):9836. doi: 10.1038/s41598-020-66869-y. Sci Rep. 2020. PMID: 32555309 Free PMC article.
A cross-linking technique involving application of Bacteriochlorophyll Derivative WST-11 mixed with dextran (WST-D) to the epithelium-debrided cornea and illumination with Near Infrared (NIR), has been identified as a promising therapy for stiffening patholog …
A cross-linking technique involving application of Bacteriochlorophyll Derivative WST-11 mixed with dextran (WST-D) to …
An image guided treatment platform for prostate cancer photodynamic therapy.
Betrouni N, Colin P, Puech P, Villers A, Mordon S. Betrouni N, et al. Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:370-3. doi: 10.1109/EMBC.2013.6609514. Annu Int Conf IEEE Eng Med Biol Soc. 2013. PMID: 24109701
This study describes a multimodality images based platform to drive photodynamic therapies of prostate cancer using WST 11 TOOKAD Soluble drug. The platform integrates a pre-treatment planning tool based on magnetic resonance imaging and a per-treatment guidance too …
This study describes a multimodality images based platform to drive photodynamic therapies of prostate cancer using WST 11 TOO …
Contrast enhanced ultrasound imaging can predict vascular-targeted photodynamic therapy induced tumor necrosis in small animals.
Cornelis FH, Kim K, Durack JC, Jebiwott S, Scherz A, Srimathveeravalli G, Coleman JA. Cornelis FH, et al. Photodiagnosis Photodyn Ther. 2017 Dec;20:165-168. doi: 10.1016/j.pdpdt.2017.09.002. Epub 2017 Sep 5. Photodiagnosis Photodyn Ther. 2017. PMID: 28887222 Free PMC article.
AIMS: To evaluate the accuracy of contrast-enhanced ultrasound (CEUS) for monitoring tumor necrosis following WST-11 vascular targeted photodynamic therapy (VTP) using imaging-pathology correlation. ...
AIMS: To evaluate the accuracy of contrast-enhanced ultrasound (CEUS) for monitoring tumor necrosis following WST-11 vascular …