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4,439 results

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Page 1
Dravet syndrome.
Lagae L. Lagae L. Curr Opin Neurol. 2021 Apr 1;34(2):213-218. doi: 10.1097/WCO.0000000000000902. Curr Opin Neurol. 2021. PMID: 33395108 Review.
RECENT FINDINGS: Comprehensive guidelines for a more standardized treatment in children with Dravet syndrome have been published. First-line and second-line treatments actually include only a few antiseizure medications, such as valproate, clobazam, stiripentol
RECENT FINDINGS: Comprehensive guidelines for a more standardized treatment in children with Dravet syndrome have been publish …
International consensus on diagnosis and management of Dravet syndrome.
Wirrell EC, Hood V, Knupp KG, Meskis MA, Nabbout R, Scheffer IE, Wilmshurst J, Sullivan J. Wirrell EC, et al. Epilepsia. 2022 Jul;63(7):1761-1777. doi: 10.1111/epi.17274. Epub 2022 May 12. Epilepsia. 2022. PMID: 35490361 Free PMC article.
OBJECTIVE: This study was undertaken to gain consensus from experienced physicians and caregivers regarding optimal diagnosis and management of Dravet syndrome (DS), in the context of recently approved, DS-specific therapies and emerging disease-modifying treatments …
OBJECTIVE: This study was undertaken to gain consensus from experienced physicians and caregivers regarding optimal diagnosis and management …
Fenfluramine for Treatment-Resistant Seizures in Patients With Dravet Syndrome Receiving Stiripentol-Inclusive Regimens: A Randomized Clinical Trial.
Nabbout R, Mistry A, Zuberi S, Villeneuve N, Gil-Nagel A, Sanchez-Carpintero R, Stephani U, Laux L, Wirrell E, Knupp K, Chiron C, Farfel G, Galer BS, Morrison G, Lock M, Agarwal A, Auvin S; FAiRE, DS Study Group. Nabbout R, et al. JAMA Neurol. 2020 Mar 1;77(3):300-308. doi: 10.1001/jamaneurol.2019.4113. JAMA Neurol. 2020. PMID: 31790543 Free PMC article. Clinical Trial.
IMPORTANCE: Fenfluramine treatment may reduce monthly convulsive seizure frequency in patients with Dravet syndrome who have poor seizure control with their current stiripentol-containing antiepileptic drug regimens. ...Eligible patients were children aged 2 …
IMPORTANCE: Fenfluramine treatment may reduce monthly convulsive seizure frequency in patients with Dravet syndrome who have p …
Comparative efficacy and safety of stiripentol, cannabidiol and fenfluramine as first-line add-on therapies for seizures in Dravet syndrome: A network meta-analysis.
Guerrini R, Chiron C, Vandame D, Linley W, Toward T. Guerrini R, et al. Epilepsia Open. 2024 Apr;9(2):689-703. doi: 10.1002/epi4.12923. Epub 2024 Mar 1. Epilepsia Open. 2024. PMID: 38427284 Free PMC article.
OBJECTIVES: Stiripentol, fenfluramine, and cannabidiol are licensed add-on therapies to treat seizures in Dravet Syndrome (DS). ...The risk of discontinuations due to AEs was lower for stiripentol, although the stiripentol trials were shorter. S …
OBJECTIVES: Stiripentol, fenfluramine, and cannabidiol are licensed add-on therapies to treat seizures in Dravet Syndrome
Stiripentol for Dravet syndrome.
[No authors listed] [No authors listed] Aust Prescr. 2020 Jun;43(3):102. doi: 10.18773/austprescr.2020.029. Epub 2020 Apr 24. Aust Prescr. 2020. PMID: 32675915 Free PMC article. Review. No abstract available.
Genetic therapeutic advancements for Dravet Syndrome.
Chilcott E, Díaz JA, Bertram C, Berti M, Karda R. Chilcott E, et al. Epilepsy Behav. 2022 Jul;132:108741. doi: 10.1016/j.yebeh.2022.108741. Epub 2022 May 30. Epilepsy Behav. 2022. PMID: 35653814 Free article. Review.
Dravet Syndrome is a genetic epileptic syndrome characterized by severe and intractable seizures associated with cognitive, motor, and behavioral impairments. ...In this review, we summarize our current knowledge of novel genetic therapies that are currently under d
Dravet Syndrome is a genetic epileptic syndrome characterized by severe and intractable seizures associated with cognitive, mo
Stiripentol (Diacomit) for Dravet syndrome.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2021 Mar 22;63(1620):e48-e50. Med Lett Drugs Ther. 2021. PMID: 33976090 Review. No abstract available.
Pharmacotherapy for Dravet Syndrome: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
Lattanzi S, Trinka E, Russo E, Del Giovane C, Matricardi S, Meletti S, Striano P, Damavandi PT, Silvestrini M, Brigo F. Lattanzi S, et al. Drugs. 2023 Oct;83(15):1409-1424. doi: 10.1007/s40265-023-01936-y. Epub 2023 Sep 11. Drugs. 2023. PMID: 37695433 Free PMC article.
BACKGROUND: Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy characterized by drug-resistant, lifelong seizures. ...Stiripentol had a higher risk of AE occurrence than pharmaceutical-grade cannabidiol (OR 75.72, 95% CI 3.59-1598.58) …
BACKGROUND: Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy characterized by drug-resistant, lifel …
Dravet syndrome: Advances in etiology, clinical presentation, and treatment.
He Z, Li Y, Zhao X, Li B. He Z, et al. Epilepsy Res. 2022 Dec;188:107041. doi: 10.1016/j.eplepsyres.2022.107041. Epub 2022 Oct 29. Epilepsy Res. 2022. PMID: 36368227 Review.
Dravet syndrome (DS) is a form of genetic refractory epilepsy. More than 80 % of DS patients carry pathogenic SCN1A mutations, and this percentage is actually higher due to false-negative results in gene testing. ...The combination of valproic acid, clobazam and
Dravet syndrome (DS) is a form of genetic refractory epilepsy. More than 80 % of DS patients carry pathogenic SCN1A mutations,
Defining Dravet syndrome: An essential pre-requisite for precision medicine trials.
Li W, Schneider AL, Scheffer IE. Li W, et al. Epilepsia. 2021 Sep;62(9):2205-2217. doi: 10.1111/epi.17015. Epub 2021 Aug 2. Epilepsia. 2021. PMID: 34338318 Free PMC article.
Patients with SCN1A pathogenic variants were reviewed and only those with Dravet syndrome were included. Clinical data, including seizure and developmental course, were analyzed in all patients with SCN1A-Dravet syndrome. ...SIGNIFICANCE: An evidence-b …
Patients with SCN1A pathogenic variants were reviewed and only those with Dravet syndrome were included. Clinical data, includ …
4,439 results