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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1992 21
1993 82
1994 107
1995 158
1996 177
1997 187
1998 303
1999 308
2000 276
2001 350
2002 398
2003 478
2004 654
2005 867
2006 1096
2007 1317
2008 1573
2009 1835
2010 2326
2011 2520
2012 2832
2013 3131
2014 2984
2015 3141
2016 3061
2017 3233
2018 3123
2019 1204
2020 16
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33,012 results
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Page 1
Immunological hallmarks of stromal cells in the tumour microenvironment.
Turley SJ, et al. Nat Rev Immunol 2015 - Review. PMID 26471778
A dynamic and mutualistic interaction between tumour cells and the surrounding stroma promotes the initiation, progression, metastasis and chemoresistance of solid tumours. ...In this Review, we discuss the evidence that stromal determinants interact with leukocytes and influence antitumour immunity, with emphasis on the immunological attributes of stromal cells that may foster their protumorigenic function....
A dynamic and mutualistic interaction between tumour cells and the surrounding stroma promotes the initiation, progression, metastasi …
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.
Dominici M, et al. Cytotherapy 2006. PMID 16923606
The considerable therapeutic potential of human multipotent mesenchymal stromal cells (MSC) has generated markedly increasing interest in a wide variety of biomedical disciplines. ...To begin to address this issue, the Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy proposes minimal criteria to define human MSC. ...
The considerable therapeutic potential of human multipotent mesenchymal stromal cells (MSC) has generated markedly increasing …
Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases.
Shi Y, et al. Nat Rev Nephrol 2018 - Review. PMID 29895977
Mesenchymal stem cells (MSCs; also referred to as mesenchymal stromal cells) have attracted much attention for their ability to regulate inflammatory processes. ...The mechanisms by which MSCs exert their therapeutic effects are multifaceted, but in general, these cells are thought to enable damaged tissues to form a balanced inflammatory and regenerative microenvironment in the presence of vigorous inflammation. ...
Mesenchymal stem cells (MSCs; also referred to as mesenchymal stromal cells) have attracted much attention for their ab …
Stromal cells in health and disease.
Schildberg FA and Donnenberg VS. Cytometry A 2018. PMID 30256523 Free article.
Immunosuppression by Intestinal Stromal Cells.
Pinchuk IV and Powell DW. Adv Exp Med Biol 2018 - Review. PMID 30155625
This chapter summarizes evidence that intestinal myofibroblasts, also called intestinal stromal cells, are derived in the adult from tissue mesenchymal stem cells under homeostasis and may be replenished by bone marrow mesenchymal stromal (stem) cells that are recruited after severe intestinal injury. ...Further, both mesenchymal stem cells and intestinal stromal cells express an almost identical repertoire of CD molecules. Lastly, others have reported that isolate intestinal stromal cells are capable of differentiating into bone and less well into chondrocyte, but not into adipocytes, a finding that we have confirmed. ...
This chapter summarizes evidence that intestinal myofibroblasts, also called intestinal stromal cells, are derived in the adul …
Endometriosis
Bulun SE, et al. Endocr Rev 2019 - Review. PMID 30994890 Free PMC article.
Although endometriotic stromal cells, which compose the bulk of endometriotic lesions, do not carry somatic mutations, they demonstrate specific epigenetic abnormalities that alter expression of key transcription factors. ...It is not known how interactions between epigenomically defective stromal cells and the mutated genes in epithelial cells contribute to the pathogenesis of endometriosis. ...
Although endometriotic stromal cells, which compose the bulk of endometriotic lesions, do not carry somatic mutations, they de …
Stromal cells and stem cells in clinical bone regeneration.
Grayson WL, et al. Nat Rev Endocrinol 2015 - Review. PMID 25560703 Free PMC article.
Successful regenerative outcomes in these investigations have provided a solid foundation for wider use of stromal cells in skeletal repair therapy. However, employing stromal cells to facilitate or enhance bone repair is far from being adopted into clinical practice. Scientific, technical, practical and regulatory obstacles prevent the widespread therapeutic use of stromal cells. ...
Successful regenerative outcomes in these investigations have provided a solid foundation for wider use of stromal cells in sk …
Epigenetic interplay between immune, stromal and cancer cells in the tumor microenvironment.
Garcia-Gomez A, et al. Clin Immunol 2018 - Review. PMID 29501540
The reciprocal interplay between neoplastic and non-tumoral host cells is mediated by direct cell-to-cell contact, soluble factors and exosomes that result in differential gene expression patterns that are driven by epigenetic mechanisms. ...This review summarizes the current knowledge on epigenetic changes that result from the interactions between myeloid, stromal and cancer cells in the tumor microenvironment and its functional impact in both tumorigenesis and tumor progression. ...
The reciprocal interplay between neoplastic and non-tumoral host cells is mediated by direct cell-to-cell contact, solu …
CD34+ stromal cells/fibroblasts/fibrocytes/telocytes as a tissue reserve and a principal source of mesenchymal cells. Location, morphology, function and role in pathology.
Díaz-Flores L, et al. Histol Histopathol 2014 - Review. PMID 24488810
We review the morphofunctional characteristics of CD34+ stromal fibroblastic/fibrocytic cells (CD34+ SFCs) and report our observations. ...Since CD34+ SFCs are the main reservoir of tissue mesenchymal cells (great mesenchymal potential, probably higher than that proposed for pericytes and other stromal cells), we dedicate a broad section to explain their in vivo behaviour during proliferation and differentiation in different physiologic and pathologic conditions, in addition to their characteristics in the human tissues of origin (adult stem cell niches); G) Involvement in pathological processes, e.g., repair (regeneration and repair through granulation tissue), fibrosis, tumour stroma formation and possible CD34+ SFC-derived tumours (e.g., solitary fibrous tumour, dermatofibrosarcoma protuberans, giant cell fibroblastoma, nuchal-type fibroma, mammary and extramammary myofibroblastoma, spindle and pleomorphic cell lipoma, and elastofibroma) and H) Clinical and therapeutic implications....
We review the morphofunctional characteristics of CD34+ stromal fibroblastic/fibrocytic cells (CD34+ SFCs) and report our obse …
Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-conditioning.
Ferreira JR, et al. Front Immunol 2018 - Review. PMID 30564236 Free PMC article.
Mesenchymal stromal cells (MSCs) are self-renewing, culture-expandable adult stem cells that have been isolated from a variety of tissues, and possess multipotent differentiation capacity, immunomodulatory properties, and are relatively non-immunogenic. Due to this unique set of characteristics, these cells have attracted great interest in the field of regenerative medicine and have been shown to possess pronounced therapeutic potential in many different pathologies. ...
Mesenchymal stromal cells (MSCs) are self-renewing, culture-expandable adult stem cells that have been isolated from a …
33,012 results
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