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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 1
1948 1
1951 1
1952 18
1953 1
1955 2
1961 1
1962 2
1964 1
1965 28
1966 54
1967 63
1968 82
1969 104
1970 158
1971 163
1972 179
1973 236
1974 303
1975 219
1976 223
1977 261
1978 238
1979 237
1980 238
1981 285
1982 231
1983 261
1984 250
1985 310
1986 294
1987 318
1988 378
1989 521
1990 632
1991 720
1992 755
1993 914
1994 980
1995 890
1996 899
1997 974
1998 958
1999 1023
2000 1041
2001 1112
2002 1307
2003 1524
2004 1729
2005 2072
2006 2420
2007 2761
2008 2915
2009 2806
2010 2742
2011 2868
2012 3067
2013 3462
2014 3543
2015 3581
2016 3352
2017 3615
2018 3415
2019 1385
2020 25
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59,138 results
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Page 1
The genetic epidemiology of substance use disorder: A review.
Prom-Wormley EC, et al. Drug Alcohol Depend 2017 - Review. PMID 28938182 Free PMC article.
Epigenetic studies indicate drug-specific changes in gene expression as well as differences in gene expression related to the use of multiple substances. Further, gene expression is expected to differ by stage of SUD such as substance initiation versus chronic substance use. While a substantial literature has developed for alcohol and nicotine use disorders, there is comparatively less information for other commonly abused substances. ...
Epigenetic studies indicate drug-specific changes in gene expression as well as differences in gene expression related to the use of …
Co-Occurrence of Substance-Related and Other Mental Health Disorders Among Adolescent Cannabis Users.
Zaman T, et al. J Addict Med 2015. PMID 26083957
We wondered what the rates of cannabis abuse and dependence might be among adolescents referred for substance use evaluations and also about the incidence of co-occurring psychiatric illnesses and substance use disorders among those individuals. ...CONCLUSIONS: Our results show that cannabis use carries the risk of dependence and also carries with it significant risk of comorbidities, both with respect to other substance use disorders and other psychiatric illness. ...
We wondered what the rates of cannabis abuse and dependence might be among adolescents referred for substance use evaluations and als …
Association of Substance Use Disorders With Conversion From Schizotypal Disorder to Schizophrenia.
Hjorthøj C, et al. JAMA Psychiatry 2018. PMID 29710317 Free PMC article.
When data were stratified by substance, cannabis use disorders (HR, 1.30; 95% CI, 1.01-1.68), amphetamine use disorders (HR, 1.90; 95% CI, 1.14-3.17), and opioid use disorders (HR, 2.74; 95% CI, 1.38-5.45) were associated with conversion to schizophrenia. ...However, conversion rates are high even in those without substance use disorders, indicating a need for universal and substance-targeted prevention in individuals with schizotypal disorder....
When data were stratified by substance, cannabis use disorders (HR, 1.30; 95% CI, 1.01-1.68), amphetamine use disorders
Anxiety and substance use disorders: co-occurrence and clinical issues.
Vorspan F, et al. Curr Psychiatry Rep 2015 - Review. PMID 25617040
The co-occurrence of substance use disorders (SUDs) and anxiety disorders has been now well established. This association is frequent and can be explained by three models: the shared vulnerability factors model, the self-medication model, and the substance-induced model. General population epidemiological studies provide strong evidence of the frequency of the association for the most used substances: tobacco, alcohol, cannabis, and to a lesser extent sedatives, opiates, and cocaine. ...
The co-occurrence of substance use disorders (SUDs) and anxiety disorders has been now well established. This associati …
Epidemiology of DSM-5 Drug Use Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions-III.
Grant BF, et al. JAMA Psychiatry 2016. PMID 26580136 Free PMC article.
DESIGN, SETTING, AND PARTICIPANTS: In-person interviews were conducted with 36,309 adults in the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions-III, a cross-sectional representative survey of the United States. ...Significant associations were found between 12-month and lifetime DUD and other substance use disorders. Significant associations were also found between any 12-month DUD and major depressive disorder (odds ratio [OR], 1.3; 95% CI, 1.09-1.64), dysthymia (OR, 1.5; 95% CI, 1.09-2.02), bipolar I (OR, 1.5; 95% CI, 1.06-2.05), posttraumatic stress disorder (OR, 1.6; 95% CI, 1.27-2.10), and antisocial (OR, 1.4; 95% CI, 1.11-1.75), borderline (OR, 1.8; 95% CI, 1.41-2.24), and schizotypal (OR, 1.5; 95% CI, 1.18-1.87) personality disorders. ...
DESIGN, SETTING, AND PARTICIPANTS: In-person interviews were conducted with 36,309 adults in the 2012-2013 National Epidemiologic Sur …
Persistence/recurrence of and remission from DSM-5 substance use disorders in the United States: Substance-specific and substance-aggregated correlates.
McCabe SE, et al. J Subst Abuse Treat 2018. PMID 30126540 Free PMC article.
This study examined demographic and psychosocial correlates associated with persistence/recurrence of and remission from at least one of ten DSM-5 substance use disorders (SUDs) and three substance-specific SUDs (i.e., alcohol, cannabis, and prescription opioids). Data were collected from structured diagnostic interviews and national prevalence estimates were derived from the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions. ...
This study examined demographic and psychosocial correlates associated with persistence/recurrence of and remission from at least one of ten …
A question of substance.
The Lancet Psychiatry . Lancet Psychiatry 2019. PMID 31006424
Intercorrelation of Alcohol and Other Drug Use Disorders among a National Sample of Drivers.
Scherer M, et al. J Psychoactive Drugs 2018. PMID 28846058 Free PMC article.
Results suggest significant poly-substance use disorders in a sample of nighttime drivers, with variations by demographic characteristics. The individual and public health consequences of multiple substance use disorders among drivers are significant....
Results suggest significant poly-substance use disorders in a sample of nighttime drivers, with variations by demographic char …
Trends in substance use admissions among older adults.
Chhatre S, et al. BMC Health Serv Res 2017. PMID 28830504 Free PMC article.
BACKGROUND: Substance abuse is a growing, but mostly silent, epidemic among older adults. We sought to analyze the trends in admissions for substance abuse treatment among older adults (aged 55 and older). ...Substantial changes in the demographic, substance use pattern, and treatment characteristics for the older adult admissions were noted. ...
BACKGROUND: Substance abuse is a growing, but mostly silent, epidemic among older adults. We sought to analyze the trends in admissio …
Extent of illicit drug use and dependence, and their contribution to the global burden of disease
Degenhardt L and Hall W. Lancet 2012 - Review. PMID 22225671
The major adverse health effects of cannabis use are dependence and probably psychotic disorders and other mental disorders. The health-related harms of cannabis use differ from those of amphetamine, cocaine, and opioid use, in that cannabis contributes little to mortality. ...
The major adverse health effects of cannabis use are dependence and probably psychotic disorders and other mental disorders. T …
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