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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1917 2
1924 2
1927 2
1928 2
1930 1
1931 2
1934 1
1937 1
1938 1
1939 2
1940 2
1941 2
1945 2
1946 5
1947 22
1948 26
1949 16
1950 15
1951 34
1952 24
1953 20
1954 27
1955 20
1956 29
1957 21
1958 17
1959 25
1960 24
1961 30
1962 32
1963 41
1964 36
1965 21
1966 12
1967 18
1968 11
1969 15
1970 8
1971 7
1972 2
1973 12
1974 11
1975 17
1976 18
1977 20
1978 16
1979 19
1980 18
1981 58
1982 65
1983 49
1984 80
1985 76
1986 69
1987 65
1988 53
1989 61
1990 57
1991 74
1992 62
1993 75
1994 103
1995 79
1996 85
1997 88
1998 110
1999 95
2000 102
2001 101
2002 122
2003 149
2004 133
2005 151
2006 180
2007 172
2008 198
2009 201
2010 236
2011 247
2012 236
2013 285
2014 282
2015 250
2016 293
2017 280
2018 311
2019 321
2020 361
2021 366
2022 409
2023 388
2024 391
2025 414
2026 1

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7,906 results

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Page 1
Role of succinic acid in the regulation of sepsis.
Liu H, Zhang H, Zhang X, Chen Q, Xia L. Liu H, et al. Int Immunopharmacol. 2022 Sep;110:109065. doi: 10.1016/j.intimp.2022.109065. Epub 2022 Jul 16. Int Immunopharmacol. 2022. PMID: 35853278 Free article. Review.
Metabolic intermediates such as elevated succinic acid levels are significantly altered in patients with sepsis. Succinic acid, a metabolic intermediate of the tricarboxylic acid cycle, participates in energy supply and plays a role in metabolic reprog …
Metabolic intermediates such as elevated succinic acid levels are significantly altered in patients with sepsis. Succinic …
Biosynthetic Pathway and Metabolic Engineering of Succinic Acid.
Liu X, Zhao G, Sun S, Fan C, Feng X, Xiong P. Liu X, et al. Front Bioeng Biotechnol. 2022 Mar 8;10:843887. doi: 10.3389/fbioe.2022.843887. eCollection 2022. Front Bioeng Biotechnol. 2022. PMID: 35350186 Free PMC article. Review.
To date, several metabolic engineering approaches have been utilized for constructing and optimizing succinic acid cell factories. In this review, different succinic acid biosynthesis pathways are summarized, with a focus on the key enzymes and metabol …
To date, several metabolic engineering approaches have been utilized for constructing and optimizing succinic acid cell factor …
Progress of succinic acid production from renewable resources: Metabolic and fermentative strategies.
Jiang M, Ma J, Wu M, Liu R, Liang L, Xin F, Zhang W, Jia H, Dong W. Jiang M, et al. Bioresour Technol. 2017 Dec;245(Pt B):1710-1717. doi: 10.1016/j.biortech.2017.05.209. Epub 2017 Jun 3. Bioresour Technol. 2017. PMID: 28622981 Review.
Facing the shortage of crude oil supply and demand of sustainable development, biological production of succinic acid from renewable resources has become a topic of worldwide interest. In recent decades, robust producing strain selection, metabolic engineering of mo …
Facing the shortage of crude oil supply and demand of sustainable development, biological production of succinic acid from ren …
Advancing Succinic Acid Biomanufacturing Using the Nonconventional Yeast Yarrowia lipolytica.
Sun T, Sun ML, Lin L, Gao J, Wang K, Ji XJ. Sun T, et al. J Agric Food Chem. 2025 Jan 8;73(1):100-109. doi: 10.1021/acs.jafc.4c09990. Epub 2024 Dec 21. J Agric Food Chem. 2025. PMID: 39707966 Review.
Succinic acid is an essential bulk chemical with wide-ranging applications in materials, food, and pharmaceuticals. ...This review summarizes the research progress on succinic acid biomanufacturing using Y. lipolytica. First, it introduces the major me …
Succinic acid is an essential bulk chemical with wide-ranging applications in materials, food, and pharmaceuticals. ...This re …
[Advances in synthesis of succinic acid using yeast cell factories].
Zhong Y, Shang C, Wang Y, Li J, Liu C, Cui Z, Qi Q. Zhong Y, et al. Sheng Wu Gong Cheng Xue Bao. 2024 Aug 25;40(8):2644-2665. doi: 10.13345/j.cjb.240349. Sheng Wu Gong Cheng Xue Bao. 2024. PMID: 39174474 Free article. Review. Chinese.
This paper systematically introduced the application value and market size of succinic acid, summarized the pathways and key enzymes involved in succinic acid synthesis in microorganisms, and elaborated on the latest research progress in the synthesis …
This paper systematically introduced the application value and market size of succinic acid, summarized the pathways and key e …
Succinic acid production from xylose mother liquor by recombinant Escherichia coli strain.
Wang H, Pan J, Wang J, Wang N, Zhang J, Li Q, Wang D, Zhou X. Wang H, et al. Biotechnol Biotechnol Equip. 2014 Nov 2;28(6):1042-1049. doi: 10.1080/13102818.2014.952501. Epub 2014 Nov 3. Biotechnol Biotechnol Equip. 2014. PMID: 26019590 Free PMC article. Review.
Succinic acid (1,4-butanedioic acid) is identified as one of important building-block chemicals. ...The optimal conditions of succinic acid fermentation were as follows: 82.62 g L(-1) total initial sugars, 42.27 g L(-1) MgCO(3) and 17.84 g L(-1) yeast …
Succinic acid (1,4-butanedioic acid) is identified as one of important building-block chemicals. ...The optimal conditions of …
Succinic acid inhibits the activity of cytochrome P450 (CYP450) enzymes.
Wang H, Xia B, Lin M, Wang Y, Sun B, Li Y. Wang H, et al. Pharm Biol. 2020 Dec;58(1):1150-1155. doi: 10.1080/13880209.2020.1839110. Pharm Biol. 2020. PMID: 33327821 Free PMC article.
CONTEXT: Succinic acid, extracted from amber, is widely used in cardiovascular therapy. OBJECTIVE: The effect of succinic acid on the activity of cytochrome P450 (CYP450) enzymes was investigated in this study. ...Succinic acid should be …
CONTEXT: Succinic acid, extracted from amber, is widely used in cardiovascular therapy. OBJECTIVE: The effect of succinic …
Succinic acid exacerbates experimental autoimmune uveitis by stimulating neutrophil extracellular traps formation via SUCNR1 receptor.
Li H, Tan H, Liu Z, Pan S, Tan S, Zhu Y, Wang Q, Su G, Zhou C, Cao Q, Yang P. Li H, et al. Br J Ophthalmol. 2023 Nov;107(11):1744-1749. doi: 10.1136/bjophthalmol-2021-320880. Epub 2022 Mar 28. Br J Ophthalmol. 2023. PMID: 35346946
METHODS: Succinic acid was administrated intraperitoneally to evaluate its effects on immune response and EAU in mice. ...In the experiment of receptor antagonism, the upregulatory effect of succinic acid on NETs could be significantly blocked by SUCNR …
METHODS: Succinic acid was administrated intraperitoneally to evaluate its effects on immune response and EAU in mice. ...In t …
Succinic acid production from softwood with genome-edited Corynebacterium glutamicum using the CRISPR-Cpf1 system.
Lee DS, Cho EJ, Nguyen DT, Song Y, Chang J, Bae HJ. Lee DS, et al. Biotechnol J. 2024 Jan;19(1):e2300309. doi: 10.1002/biot.202300309. Epub 2024 Jan 5. Biotechnol J. 2024. PMID: 38180273
The co-expression transformant, [Psod:SucE-deltaldhA] produced 17.70 g L(-1) succinic acid in 6 h. In the fed-batch system, 39.67 g L(-1) succinic acid was produced over 48 h. During the fermentation, the strain consumed 100% and 73% of glucose and xyl …
The co-expression transformant, [Psod:SucE-deltaldhA] produced 17.70 g L(-1) succinic acid in 6 h. In the fed-batch system, 39 …
Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1.
Zhou Y, Zhang F, Jiang H, Xu D, Deng D. Zhou Y, et al. Exp Ther Med. 2021 Oct;22(4):1072. doi: 10.3892/etm.2021.10506. Epub 2021 Jul 28. Exp Ther Med. 2021. PMID: 34447465 Free PMC article.
Nomega-Nitro-L-arginine methyl ester hydrochloride was injected into rats to establish a gestational hypertension model. Dimethyl fumarate (DMF) and succinic acid were administrated into rats to treat gestational hypertension. Rats were divided into five groups: i) …
Nomega-Nitro-L-arginine methyl ester hydrochloride was injected into rats to establish a gestational hypertension model. Dimethyl fumarate ( …
7,906 results