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157 results

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Page 1
Sulforaphane-driven reprogramming of gut microbiome and metabolome ameliorates the progression of hyperuricemia.
Wang R, Halimulati M, Huang X, Ma Y, Li L, Zhang Z. Wang R, et al. J Adv Res. 2023 Oct;52:19-28. doi: 10.1016/j.jare.2022.11.003. Epub 2022 Nov 10. J Adv Res. 2023. PMID: 36371056 Free PMC article.
RESULTS: Sulforaphane could lower uric acid by decreasing urate synthesis and increasing renal urate excretion in hyperuricemic rats (P<0.05). We identified succinic acid and oxoglutaric acid as critical host-gut microbiome co-metabolites. Moreover, sulforaphane …
RESULTS: Sulforaphane could lower uric acid by decreasing urate synthesis and increasing renal urate excretion in hyperuricemic rats (P<0 …
Efficacy and safety of the combined metabolic medication, containing inosine, nicotinamide, riboflavin and succinic acid, for the treatment of diabetic neuropathy: a multicenter randomized, double-blind, placebo-controlled parallel group clinical trial (CYLINDER).
Kharitonova T, Shvarts YG, Verbovoy AF, Orlova NS, Puzyreva VP, Strokov IA. Kharitonova T, et al. BMJ Open Diabetes Res Care. 2022 Jun;10(3):e002785. doi: 10.1136/bmjdrc-2022-002785. BMJ Open Diabetes Res Care. 2022. PMID: 35680173 Free PMC article. Clinical Trial.
INTRODUCTION: Antioxidants may have positive impact on diabetic polyneuropathy (DPN), presumably due to alleviation of oxidative stress. We aimed to evaluate the efficacy and safety of combination of antioxidants: succinic acid, inosine, nicotinamide, and rib …
INTRODUCTION: Antioxidants may have positive impact on diabetic polyneuropathy (DPN), presumably due to alleviation of oxidative stress. We …
Low-concentration iron promotes Klebsiella pneumoniae biofilm formation by suppressing succinic acid.
Liu K, Tan S, Ye W, Hou L, Fang B. Liu K, et al. BMC Microbiol. 2022 Apr 11;22(1):95. doi: 10.1186/s12866-022-02518-w. BMC Microbiol. 2022. PMID: 35410114 Free PMC article.
To clarify this mechanism, intracellular metabolomic analysis was carried out, showing that the differential, down-regulated metabolites included succinic acid. The addition of 1.7 mM succinic acid counteracted the biofilm-forming effect of iron, with …
To clarify this mechanism, intracellular metabolomic analysis was carried out, showing that the differential, down-regulated metabolites inc …
Comparison of lodging safety factor of untreated and succinic Acid 2,2-dimethylhydrazide-treated shoots of mulberry tree.
Tateno M, Bae K. Tateno M, et al. Plant Physiol. 1990 Jan;92(1):12-6. doi: 10.1104/pp.92.1.12. Plant Physiol. 1990. PMID: 16667232 Free PMC article.
This study examined the lodging resistance of mulberry tree (Morus bombycis Koidz. cv Kenmochi) shoots treated or not treated with succinic acid 2,2-dimethylhydrazide (SADH). The lodging safety factor, an indicator of lodging resistance, was defined as the ra …
This study examined the lodging resistance of mulberry tree (Morus bombycis Koidz. cv Kenmochi) shoots treated or not treated with succin …
Evaluation of certain food additives.
World Health Organization. World Health Organization. World Health Organ Tech Rep Ser. 2017;(1000):1-162. World Health Organ Tech Rep Ser. 2017. PMID: 29144073
This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various food additives, including flavouring agents, with a view to concluding as to safety concerns and to preparing specifications for identity and purity …
This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various food additives, …
Caulerpa chemnitzia polysaccharide exerts immunomodulatory activity in macrophages by mediating the succinate/PHD2/HIF-1α/IL-1β pathway.
Zeng J, Liu J, Zhao N, Wong IN, Huang R. Zeng J, et al. Int J Biol Macromol. 2024 Oct;277(Pt 3):134450. doi: 10.1016/j.ijbiomac.2024.134450. Epub 2024 Aug 3. Int J Biol Macromol. 2024. PMID: 39098690
Additionally, the result of joint analysis of untargeted metabolomics showed metabolism played a major role in the immunomodulatory of CRVP and suggested succinic acid was a key metabolite. Further verification indicated that the accumulation of succinic a …
Additionally, the result of joint analysis of untargeted metabolomics showed metabolism played a major role in the immunomodulatory of CRVP …
The Role of Selected Lactic Acid Bacteria on Organic Acid Accumulation during Wet and Spray-Dried Fish-based Silages. Contributions to the Winning Combination of Microbial Food Safety and Environmental Sustainability.
Kuley E, Özyurt G, Özogul I, Boga M, Akyol I, Rocha JM, Özogul F. Kuley E, et al. Microorganisms. 2020 Jan 25;8(2):172. doi: 10.3390/microorganisms8020172. Microorganisms. 2020. PMID: 31991813 Free PMC article.
Lactic and propionic acids were the dominant produced organic acids, while succinic acid was formed at the smallest amounts in fermented silages. In the acidified silage, lactic and formic acids were produced in amounts higher than 800 and 1000 mg (organic acid)/100 …
Lactic and propionic acids were the dominant produced organic acids, while succinic acid was formed at the smallest amounts in …
Metabolic engineering in the biotechnological production of organic acids in the tricarboxylic acid cycle of microorganisms: Advances and prospects.
Yin X, Li J, Shin HD, Du G, Liu L, Chen J. Yin X, et al. Biotechnol Adv. 2015 Nov 1;33(6 Pt 1):830-41. doi: 10.1016/j.biotechadv.2015.04.006. Epub 2015 Apr 19. Biotechnol Adv. 2015. PMID: 25902192 Review.
Organic acids in the TCA cycle include citric acid, alpha-ketoglutaric acid, succinic acid, fumaric acid, l-malic acid, and oxaloacetate, which are building-block chemicals with wide applications and huge markets. ...
Organic acids in the TCA cycle include citric acid, alpha-ketoglutaric acid, succinic acid, fumaric acid, l-malic acid, and ox …
[Regulation of intracellular level of ATP and NADH in Escherichia coli to promote succinic acid production].
Wang X, Pan J, Wu J, Chen X, Gao C, Song W, Wei W, Liu J, Liu L. Wang X, et al. Sheng Wu Gong Cheng Xue Bao. 2023 Aug 25;39(8):3236-3252. doi: 10.13345/j.cjb.221020. Sheng Wu Gong Cheng Xue Bao. 2023. PMID: 37622358 Free article. Chinese.
Succinic acid is an important C4 platform chemical that is widely used in food, chemical, medicine sectors. ...Further scale-up experiments were carried out in a 1 000 L fermenter, and the titer of succinic acid and acetic acid were 140.2 g/L and 1.38 …
Succinic acid is an important C4 platform chemical that is widely used in food, chemical, medicine sectors. ...Further scale-u …
Feed-control development for succinic acid production with Anaerobiospirillum succiniciproducens.
Bretz K, Kabasci S. Bretz K, et al. Biotechnol Bioeng. 2012 May;109(5):1187-92. doi: 10.1002/bit.24387. Epub 2011 Dec 12. Biotechnol Bioeng. 2012. PMID: 22125258
The aim of this work was the development of a feed-control for a succinic acid production fed-batch process. The performed batch trials indicated a correlation between succinic acid production and base consumption pH control. ...Additionally, the resul …
The aim of this work was the development of a feed-control for a succinic acid production fed-batch process. The performed bat …
157 results