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2007 2
2008 1
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2012 9
2013 5
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143 results

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Efficacy and safety of the combined metabolic medication, containing inosine, nicotinamide, riboflavin and succinic acid, for the treatment of diabetic neuropathy: a multicenter randomized, double-blind, placebo-controlled parallel group clinical trial (CYLINDER).
Kharitonova T, Shvarts YG, Verbovoy AF, Orlova NS, Puzyreva VP, Strokov IA. Kharitonova T, et al. BMJ Open Diabetes Res Care. 2022 Jun;10(3):e002785. doi: 10.1136/bmjdrc-2022-002785. BMJ Open Diabetes Res Care. 2022. PMID: 35680173 Free PMC article. Clinical Trial.
INTRODUCTION: Antioxidants may have positive impact on diabetic polyneuropathy (DPN), presumably due to alleviation of oxidative stress. We aimed to evaluate the efficacy and safety of combination of antioxidants: succinic acid, inosine, nicotinamide, and rib …
INTRODUCTION: Antioxidants may have positive impact on diabetic polyneuropathy (DPN), presumably due to alleviation of oxidative stress. We …
Low-concentration iron promotes Klebsiella pneumoniae biofilm formation by suppressing succinic acid.
Liu K, Tan S, Ye W, Hou L, Fang B. Liu K, et al. BMC Microbiol. 2022 Apr 11;22(1):95. doi: 10.1186/s12866-022-02518-w. BMC Microbiol. 2022. PMID: 35410114 Free PMC article.
To clarify this mechanism, intracellular metabolomic analysis was carried out, showing that the differential, down-regulated metabolites included succinic acid. The addition of 1.7 mM succinic acid counteracted the biofilm-forming effect of iron, with …
To clarify this mechanism, intracellular metabolomic analysis was carried out, showing that the differential, down-regulated metabolites inc …
The Role of Selected Lactic Acid Bacteria on Organic Acid Accumulation during Wet and Spray-Dried Fish-based Silages. Contributions to the Winning Combination of Microbial Food Safety and Environmental Sustainability.
Kuley E, Özyurt G, Özogul I, Boga M, Akyol I, Rocha JM, Özogul F. Kuley E, et al. Microorganisms. 2020 Jan 25;8(2):172. doi: 10.3390/microorganisms8020172. Microorganisms. 2020. PMID: 31991813 Free PMC article.
Lactic and propionic acids were the dominant produced organic acids, while succinic acid was formed at the smallest amounts in fermented silages. ...This research effort pointed out the good capability of various selected lactic acid bacteria strains to produce sign …
Lactic and propionic acids were the dominant produced organic acids, while succinic acid was formed at the smallest amounts in …
Comparison of lodging safety factor of untreated and succinic Acid 2,2-dimethylhydrazide-treated shoots of mulberry tree.
Tateno M, Bae K. Tateno M, et al. Plant Physiol. 1990 Jan;92(1):12-6. doi: 10.1104/pp.92.1.12. Plant Physiol. 1990. PMID: 16667232 Free PMC article.
This study examined the lodging resistance of mulberry tree (Morus bombycis Koidz. cv Kenmochi) shoots treated or not treated with succinic acid 2,2-dimethylhydrazide (SADH). The lodging safety factor, an indicator of lodging resistance, was defined as the ra …
This study examined the lodging resistance of mulberry tree (Morus bombycis Koidz. cv Kenmochi) shoots treated or not treated with succin
Metabolic engineering in the biotechnological production of organic acids in the tricarboxylic acid cycle of microorganisms: Advances and prospects.
Yin X, Li J, Shin HD, Du G, Liu L, Chen J. Yin X, et al. Biotechnol Adv. 2015 Nov 1;33(6 Pt 1):830-41. doi: 10.1016/j.biotechadv.2015.04.006. Epub 2015 Apr 19. Biotechnol Adv. 2015. PMID: 25902192 Review.
Organic acids in the TCA cycle include citric acid, alpha-ketoglutaric acid, succinic acid, fumaric acid, l-malic acid, and oxaloacetate, which are building-block chemicals with wide applications and huge markets. ...
Organic acids in the TCA cycle include citric acid, alpha-ketoglutaric acid, succinic acid, fumaric acid, l-malic acid, and ox …
Evaluation of certain food additives.
World Health Organization. World Health Organization. World Health Organ Tech Rep Ser. 2017;(1000):1-162. World Health Organ Tech Rep Ser. 2017. PMID: 29144073
This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various food additives, including flavouring agents, with a view to concluding as to safety concerns and to preparing specifications for identity and purity …
This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various food additives, …
Sulforaphane-driven reprogramming of gut microbiome and metabolome ameliorates the progression of hyperuricemia.
Wang R, Halimulati M, Huang X, Ma Y, Li L, Zhang Z. Wang R, et al. J Adv Res. 2023 Oct;52:19-28. doi: 10.1016/j.jare.2022.11.003. Epub 2022 Nov 10. J Adv Res. 2023. PMID: 36371056 Free PMC article.
RESULTS: Sulforaphane could lower uric acid by decreasing urate synthesis and increasing renal urate excretion in hyperuricemic rats (P<0.05). We identified succinic acid and oxoglutaric acid as critical host-gut microbiome co-metabolites. ...
RESULTS: Sulforaphane could lower uric acid by decreasing urate synthesis and increasing renal urate excretion in hyperuricemic rats (P<0 …
[Regulation of intracellular level of ATP and NADH in Escherichia coli to promote succinic acid production].
Wang X, Pan J, Wu J, Chen X, Gao C, Song W, Wei W, Liu J, Liu L. Wang X, et al. Sheng Wu Gong Cheng Xue Bao. 2023 Aug 25;39(8):3236-3252. doi: 10.13345/j.cjb.221020. Sheng Wu Gong Cheng Xue Bao. 2023. PMID: 37622358 Free article. Chinese.
Succinic acid is an important C4 platform chemical that is widely used in food, chemical, medicine sectors. ...Further scale-up experiments were carried out in a 1 000 L fermenter, and the titer of succinic acid and acetic acid were 140.2 g/L and 1.38
Succinic acid is an important C4 platform chemical that is widely used in food, chemical, medicine sectors. ...Further scale-u
Improved art bioactivity by encapsulation within cyclodextrin carboxylate.
Hu Y, Julian McClements D, Li X, Chen L, Long J, Jiao A, Xie F, Wang J, Jin Z, Qiu C. Hu Y, et al. Food Chem. 2022 Aug 1;384:132429. doi: 10.1016/j.foodchem.2022.132429. Epub 2022 Feb 11. Food Chem. 2022. PMID: 35219238
In this study, we investigated the potential of forming a host-guest complex between Art and succinic acid modified cyclodextrin (SACD) to improve its solubility characteristics. Art-SACD inclusion complexes (2:1 M ratio) were successfully formed in water, which was …
In this study, we investigated the potential of forming a host-guest complex between Art and succinic acid modified cyclodextr …
Herba Siegesbeckiae: A review on its traditional uses, chemical constituents, pharmacological activities and clinical studies.
Wang Q, Liang YY, Li KW, Li Y, Niu FJ, Zhou SJ, Wei HC, Zhou CZ. Wang Q, et al. J Ethnopharmacol. 2021 Jul 15;275:114117. doi: 10.1016/j.jep.2021.114117. Epub 2021 Apr 10. J Ethnopharmacol. 2021. PMID: 33848612 Review.
It suggested that further in-depth study of toxicity and quality control were critical for future evaluation of drug efficacy and safety....
It suggested that further in-depth study of toxicity and quality control were critical for future evaluation of drug efficacy and safety
143 results