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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 1
1964 1
1965 1
1974 2
1975 36
1976 66
1977 69
1978 116
1979 137
1980 142
1981 191
1982 257
1983 249
1984 361
1985 412
1986 492
1987 506
1988 661
1989 599
1990 691
1991 689
1992 640
1993 640
1994 662
1995 640
1996 611
1997 624
1998 662
1999 653
2000 666
2001 728
2002 728
2003 727
2004 770
2005 865
2006 874
2007 889
2008 903
2009 870
2010 846
2011 879
2012 903
2013 800
2014 673
2015 694
2016 587
2017 511
2018 445
2019 230
2020 5
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23,680 results
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Page 1
Hyperuricemia and endothelial function: From molecular background to clinical perspectives
Maruhashi T, et al. Atherosclerosis 2018 - Review. PMID 30326405 Free article.
In the process of purine metabolism, reactive oxygen species, including superoxide, are generated concomitantly with uric acid production, which may deteriorate endothelial function through the reaction of superoxide with nitric oxide (NO), leading to decreased NO bioavailability and increased production of peroxynitrite, a reactive oxidant. ...
In the process of purine metabolism, reactive oxygen species, including superoxide, are generated concomitantly with uric acid produc …
Where in the world do bacteria experience oxidative stress?
Imlay JA. Environ Microbiol 2019 - Review. PMID 30307099
Reactive oxygen species - superoxide, hydrogen peroxide and hydroxyl radicals - have long been suspected of constraining bacterial growth in important microbial habitats and indeed of shaping microbial communities. ...
Reactive oxygen species - superoxide, hydrogen peroxide and hydroxyl radicals - have long been suspected of constraining bacterial gr …
A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development
Shi Y, et al. Nat Commun 2019. PMID 31015473 Free PMC article.
Furthermore, we identify superoxide dismutase 3 (SOD3) as a mediator of BNTA activity. BNTA induces SOD3 expression and superoxide anion elimination in osteoarthritic chondrocyte culture, and ectopic SOD3 expression recapitulates the effect of BNTA on ECM biosynthesis. ...
Furthermore, we identify superoxide dismutase 3 (SOD3) as a mediator of BNTA activity. BNTA induces SOD3 expression and superoxide
Hydrogen peroxide metabolism and functions in plants
Smirnoff N and Arnaud D. New Phytol 2019 - Review. PMID 30222198 Free article.
1209 Acknowledgements 1209 References 1209 SUMMARY: Hydrogen peroxide (H(2) O(2) ) is produced, via superoxide and superoxide dismutase, by electron transport in chloroplasts and mitochondria, plasma membrane NADPH oxidases, peroxisomal oxidases, type III peroxidases and other apoplastic oxidases. ...
1209 Acknowledgements 1209 References 1209 SUMMARY: Hydrogen peroxide (H(2) O(2) ) is produced, via superoxide and superoxide
AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission
Flippo KH, et al. J Neurosci 2018. PMID 30093535 Free PMC article.
Mechanistically, deletion of AKAP1 dysregulates complex II of the electron transport chain, increases superoxide production, and impairs Ca(2+) homeostasis in neurons subjected to excitotoxic glutamate. ...Mechanistically, we show that electron transport deficiency, increased superoxide production, and Ca(2+) overload result from genetic disinhibition of Drp1. ...
Mechanistically, deletion of AKAP1 dysregulates complex II of the electron transport chain, increases superoxide production, and impa …
Insights into the respiratory chain and oxidative stress
Larosa V and Remacle C. Biosci Rep 2018 - Review. PMID 30201689 Free PMC article.
The common forms are the superoxide anion (O(2) (∙-)) and hydrogen peroxide (H(2)O(2)) and their derived forms, hydroxyl radical (HO∙) and hydroperoxyl radical (HOO∙). ...
The common forms are the superoxide anion (O(2) (∙-)) and hydrogen peroxide (H(2)O(2)) and their derived forms, hydroxyl radical (HO∙ …
Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment
Abdul-Aziz AM, et al. Blood 2019. PMID 30401703 Free PMC article.
Next, we find that the leukemia-driven senescent tumor microenvironment is caused by AML-induced NOX2-derived superoxide. Finally, using the p16-3MR mouse model, we show that by targeting NOX2 we reduced BM stromal cell senescence and consequently reduced AML proliferation. Together, these data identify leukemia-generated NOX2-derived superoxide as a driver of protumoral p16INK4a-dependent senescence in BM stromal cells. ...
Next, we find that the leukemia-driven senescent tumor microenvironment is caused by AML-induced NOX2-derived superoxide. Finally, us …
Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathway
Yin J, et al. Toxicol In Vitro 2018. PMID 29729358
Inhibition of mitophagy by mdivi-1 was found to attenuate activation of the PINK1/parkin pathway by DOX and preserve mitochondrial biogenesis, consequently mitigating DOX-induced mitochondrial superoxide overproduction and mitochondrial dysfunction. Moreover, scavenging mitochondrial superoxide by Mito-tempo was also found to effectively attenuate activation of the PINK1/parkin pathway and rescue the cells from DOX-induced adverse effects. ...
Inhibition of mitophagy by mdivi-1 was found to attenuate activation of the PINK1/parkin pathway by DOX and preserve mitochondrial biogenesi …
Control of mitochondrial superoxide production by reverse electron transport at complex I.
Robb EL, et al. J Biol Chem 2018. PMID 29743240 Free PMC article.
The generation of mitochondrial superoxide (O(2)(̇̄)) by reverse electron transport (RET) at complex I causes oxidative damage in pathologies such as ischemia reperfusion injury, but also provides the precursor to H(2)O(2) production in physiological mitochondrial redox signaling. ...
The generation of mitochondrial superoxide (O(2)(̇̄)) by reverse electron transport (RET) at complex I causes oxidative damage in pat …
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