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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 1
1992 1
1993 10
1994 37
1995 61
1996 63
1997 75
1998 53
1999 73
2000 69
2001 83
2002 65
2003 65
2004 63
2005 71
2006 80
2007 93
2008 102
2009 129
2010 125
2011 133
2012 149
2013 138
2014 143
2015 155
2016 142
2017 133
2018 111
2019 63
2020 2
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2,230 results
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Page 1
Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis.
Qu C, Zheng D, Li S, Liu Y, Lidofsky A, Holmes JA, Chen J, He L, Wei L, Liao Y, Yuan H, Jin Q, Lin Z, Hu Q, Jiang Y, Tu M, Chen X, Li W, Lin W, Fuchs BC, Chung RT, Hong J. Qu C, et al. Hepatology. 2018 Sep;68(3):1125-1139. doi: 10.1002/hep.29881. Epub 2018 May 21. Hepatology. 2018. PMID: 29537660 Free PMC article.
SYK kinase mediates brown fat differentiation and activation.
Knoll M, Winther S, Natarajan A, Yang H, Jiang M, Thiru P, Shahsafaei A, Chavarria TE, Lamming DW, Sun L, Hansen JB, Lodish HF. Knoll M, et al. Nat Commun. 2017 Dec 13;8(1):2115. doi: 10.1038/s41467-017-02162-3. Nat Commun. 2017. PMID: 29235464 Free PMC article.
JAK Inhibitors for Atopic Dermatitis: An Update.
He H, Guttman-Yassky E. He H, et al. Am J Clin Dermatol. 2019 Apr;20(2):181-192. doi: 10.1007/s40257-018-0413-2. Am J Clin Dermatol. 2019. PMID: 30536048 Review.
A reevaluation of the spleen tyrosine kinase (SYK) activation mechanism.
Mansueto MS, Reens A, Rakhilina L, Chi A, Pan BS, Miller JR. Mansueto MS, et al. J Biol Chem. 2019 May 10;294(19):7658-7668. doi: 10.1074/jbc.RA119.008045. Epub 2019 Mar 28. J Biol Chem. 2019. PMID: 30923129
Fostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: Results of two phase 3, randomized, placebo-controlled trials.
Bussel J, Arnold DM, Grossbard E, Mayer J, Treliński J, Homenda W, Hellmann A, Windyga J, Sivcheva L, Khalafallah AA, Zaja F, Cooper N, Markovtsov V, Zayed H, Duliege AM. Bussel J, et al. Am J Hematol. 2018 Jul;93(7):921-930. doi: 10.1002/ajh.25125. Epub 2018 May 15. Am J Hematol. 2018. PMID: 29696684 Free PMC article. Clinical Trial.
Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity.
Martínez-López M, Iborra S, Conde-Garrosa R, Mastrangelo A, Danne C, Mann ER, Reid DM, Gaboriau-Routhiau V, Chaparro M, Lorenzo MP, Minnerup L, Saz-Leal P, Slack E, Kemp B, Gisbert JP, Dzionek A, Robinson MJ, Rupérez FJ, Cerf-Bensussan N, Brown GD, Bernardo D, LeibundGut-Landmann S, Sancho D. Martínez-López M, et al. Immunity. 2019 Feb 19;50(2):446-461.e9. doi: 10.1016/j.immuni.2018.12.020. Epub 2019 Jan 29. Immunity. 2019. PMID: 30709742 Free PMC article.
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