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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1979 2
1980 11
1981 12
1982 34
1983 26
1984 25
1985 24
1986 20
1987 33
1988 25
1989 14
1990 32
1991 16
1992 10
1993 13
1994 6
1995 8
1996 4
1997 3
1998 4
1999 5
2000 8
2001 8
2002 14
2003 11
2004 28
2005 43
2006 109
2007 180
2008 220
2009 230
2010 269
2011 302
2012 235
2013 269
2014 228
2015 263
2016 178
2017 168
2018 132
2019 69
2020 1
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2,995 results
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Page 1
The role of interleukin-2 during homeostasis and activation of the immune system
Boyman O and Sprent J. Nat Rev Immunol 2012 - Review. PMID 22343569
Interleukin-2 (IL-2) signals influence various lymphocyte subsets during differentiation, immune responses and homeostasis. As discussed in this Review, stimulation with IL-2 is crucial for the maintenance of regulatory T (T(Reg)) cells and for the differentiation of CD4(+) T cells into defined effector T cell subsets following antigen-mediated activation. For CD8(+) T cells, IL-2 signals optimize both effector T cell generation and differentiation into memory cells. IL-2 is presented in soluble form or bound to dendritic cells and the extracellular matrix. ...
Interleukin-2 (IL-2) signals influence various lymphocyte subsets during differentiation, immune responses and homeostasis. As discus …
TGF-β Control of Adaptive Immune Tolerance: A Break From Treg Cells
Liu M, et al. Bioessays 2018 - Review. PMID 30159904 Free PMC article.
Suppression of autoreactive T cells is dependent on the regulatory cytokine transforming growth factor-β (TGF-β) and regulatory T (Treg) cells, a distinct T cell lineage specified by the transcription factor Foxp3. ...Later, perhaps in placental mammals upon their acquisition of a TGF-β regulatory element in the Foxp3 locus, the TGF-β pathway is further engaged to induce peripheral Treg cell differentiation and expand the scope of T cell tolerance control to innocuous foreign antigens....
Suppression of autoreactive T cells is dependent on the regulatory cytokine transforming growth factor-β (TGF-β) and regula
Role of α-fetoprotein in differentiation of regulatory T lymphocytes.
Chereshnev VA, et al. Dokl Biol Sci 2017. PMID 29299806
The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4(+) lymphocytes with different proliferative status was studied. α-Fetoprotein did not affect the ratio of proliferating and non-proliferating activated CD4(+) cells. In the study of Treg differentiation, it was found that AFP at concentrations of 50 and 100 μg/mL significantly inhibited the number of nonproliferating CD4(+)FOXP3(+) and CD4(+)FOXP3(+)HELIOS(+) lymphocytes without affecting the expression of Treg markers by proliferating CD4(+) lymphocytes....
The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4(+ …
Transcriptional regulation and development of regulatory T cells.
Lee W and Lee GR. Exp Mol Med 2018 - Review. PMID 29520112 Free PMC article.
Regulatory T (Treg) cells are a distinct subset of CD4(+) T cells. Instead of triggering adaptive immunity, they suppress immune responses. ...Since they were first discovered 20 years ago, efforts have been made to understand the differences in developmental processes between Treg cells and conventional T cells that determine the ultimate fate of the overall T-cell population. ...
Regulatory T (Treg) cells are a distinct subset of CD4(+) T cells. Instead of triggering adaptive immunity, they suppre
Mechanisms of T cell organotropism.
Fu H, et al. Cell Mol Life Sci 2016 - Review. PMID 27038487 Free PMC article.
While naïve T lymphocytes recirculate predominantly in secondary lymphoid tissue, primed T cells and activated Tregs must traffic to the antigen rich non-lymphoid tissue to exert effector and regulatory responses, respectively. ...We here review the molecular mechanisms supporting trafficking of both effector and regulatory T cells to specific antigen-rich tissues....
While naïve T lymphocytes recirculate predominantly in secondary lymphoid tissue, primed T cells and activated Tregs mu …
Adipose Tissue-Resident Regulatory T Cells.
Zhu F, et al. Adv Exp Med Biol 2017 - Review. PMID 28875489
Regulatory T cells have been reported to exert key roles in suppressing inflammation, thus maintaining the homeostasis of immune responses, and visceral adipose Tregs exert critical roles in defending against obesity-associated metabolic disorders. ...Here we review the recent progress in adipose tissue-resident regulatory T cells (Tregs), a subpopulation of CD4(+) T cells which suppress adipose tissue inflammation....
Regulatory T cells have been reported to exert key roles in suppressing inflammation, thus maintaining the homeostasis of immu
In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol.
Schmidt A, et al. J Vis Exp 2016. PMID 28060341 Free PMC article.
Regulatory T cells (Tregs) are an integral part of peripheral tolerance, suppressing immune reactions against self-structures and thus preventing autoimmune diseases. ...This protocol therefore describes the in vitro differentiation of human CD4+FOXP3+ iTregs from human naïve T cells using a range of Treg-inducing factors (TGF-β plus IL-2 only, or their combination with retinoic acid, rapamycin or butyrate) in parallel. ...
Regulatory T cells (Tregs) are an integral part of peripheral tolerance, suppressing immune reactions against self-structures
Control of Regulatory T Cells by Co-signal Molecules.
Wing JB, et al. Adv Exp Med Biol 2019 - Review. PMID 31758535
Foxp3-expressing regulatory T cells (Tregs) perform a vital function in the maintenance of immune homeostasis. A large part of Treg suppressive function is derived from their ability to control and restrict the availability of co-signal molecules to other T cells. ...
Foxp3-expressing regulatory T cells (Tregs) perform a vital function in the maintenance of immune homeostasis. A large part of …
Memory of Inflammation in Regulatory T Cells.
van der Veeken J, et al. Cell 2016. PMID 27499023 Free PMC article.
Regulatory T (Treg) cells are a specialized lineage of suppressive CD4 T cells that act as critical negative regulators of inflammation in various biological contexts. ...
Regulatory T (Treg) cells are a specialized lineage of suppressive CD4 T cells that act as critical negative regulators
Regulatory T Cell-Mediated Tissue Repair.
Hong J and Kim BS. Adv Exp Med Biol 2018 - Review. PMID 30471036
Regulatory T-cells (Treg cells) are a specific group of T-cells that maintain immune homeostasis by counteracting the immune responses of conventional T-cells. ...
Regulatory T-cells (Treg cells) are a specific group of T-cells that maintain immune homeostasis by counteracting the i
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