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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 5
1991 13
1992 12
1993 18
1994 27
1995 21
1996 21
1997 35
1998 28
1999 41
2000 48
2001 66
2002 59
2003 50
2004 65
2005 81
2006 160
2007 195
2008 201
2009 174
2010 110
2011 66
2012 62
2013 48
2014 34
2015 36
2016 34
2017 29
2018 24
2019 6
2020 0
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1,612 results
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Page 1
Role of TCF/LEF Transcription Factors in Bone Development and Osteogenesis.
Li Z, et al. Int J Med Sci 2018 - Review. PMID 30275770 Free PMC article.
Osteogenesis related transcription factors are the central targets and key mediators of the function of growth factors, such as cytokines. ...In this paper, we discuss the structure of T-cell factor/lymphoid enhancer factor (TCF/LEF) and its role in embryonic skeletal development and the crosstalk with related signaling pathways and factors....
Osteogenesis related transcription factors are the central targets and key mediators of the function of growth factors, …
Wnt/beta-catenin signaling: components, mechanisms, and diseases
MacDonald BT, et al. Dev Cell 2009 - Review. PMID 19619488 Free PMC article.
Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator beta-catenin controls embryonic development and adult homeostasis. ...We also dissect critical events that regulate beta-catenin stability, from Wnt receptors to the cytoplasmic beta-catenin destruction complex, and nuclear machinery that mediates beta-catenin-dependent transcription. ...
Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator beta-catenin controls embryonic develop …
ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription.
Esnault C, et al. Mol Cell 2017. PMID 28286024 Free PMC article.
Most induced changes were TCF dependent, but TCF-independent TSSs exhibited the same hierarchy, indicating that it reflects gene activation per se. Studies with TCF Elk-1 mutants showed that TCF-dependent ERK-induced histone modifications required Elk-1 to be phosphorylated and competent to activate transcription. ...
Most induced changes were TCF dependent, but TCF-independent TSSs exhibited the same hierarchy, indicating that it reflects ge …
TCF/LEF dependent and independent transcriptional regulation of Wnt/β-catenin target genes.
Doumpas N, et al. EMBO J 2019. PMID 30425074 Free PMC article.
During canonical Wnt signalling, the activity of nuclear β-catenin is largely mediated by the TCF/LEF family of transcription factors. ...By performing unbiased whole transcriptome sequencing analysis, we found that a subset of β-catenin transcriptional targets did not require TCF/LEF factors for their regulation. ...
During canonical Wnt signalling, the activity of nuclear β-catenin is largely mediated by the TCF/LEF family of transcription
TCF/LEFs and Wnt signaling in the nucleus.
Cadigan KM and Waterman ML. Cold Spring Harb Perspect Biol 2012 - Review. PMID 23024173 Free PMC article.
T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end point mediators of Wnt/Wingless signaling throughout metazoans. ...In contrast to invertebrates, which typically contain one TCF/LEF protein that can both activate and repress Wnt targets, gene duplication and isoform complexity of the family in vertebrates have led to specialization, in which individual TCF/LEF isoforms have distinct activities....
T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end point mediators of Wnt/Wingles …
The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells
Wang Q, et al. Cell Stem Cell 2017. PMID 27889317 Free PMC article.
Globally, Wnt3-activated Tcf3 and nodal-activated Smad2/3 transcription factors depend on each other for co-occupancy of target enhancers associated with key differentiation loci. Our results therefore highlight an unanticipated role for p53 family proteins in a regulatory network that integrates essential Wnt-Tcf and nodal-Smad inputs in a selective and interdependent way to drive mesendodermal differentiation of pluripotent cells....
Globally, Wnt3-activated Tcf3 and nodal-activated Smad2/3 transcription factors depend on each other for co-occupancy of targe …
A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators.
Freeman J, et al. Mol Cancer 2015. PMID 26643252 Free PMC article.
RESULTS: 141 novel regulators of TCF-dependent transcription were identified. Surprisingly, when tested without ∆NLRP activation, most up-regulators failed to alter TCF-dependent transcription. However, when expressed in pairs, 27 % (466/1170) functionally interacted to alter levels of TCF-dependent transcription. When proteins were displayed as nodes connected by their ability to co-operate in the regulation of TCF-dependent transcription, a network of functional interactions was revealed. ...
RESULTS: 141 novel regulators of TCF-dependent transcription were identified. Surprisingly, when tested without ∆NLRP activati …
Redirecting TGF-β Signaling through the β-Catenin/Foxo Complex Prevents Kidney Fibrosis
Qiao X, et al. J Am Soc Nephrol 2018. PMID 29180394 Free PMC article.
Here, we investigated the hypothesis that we can redirect TGF-β signaling by preventing downstream profibrotic interaction of β-catenin with T cell factor (TCF), thereby enhancing the interaction of β-catenin with Foxo, a transcription factor that controls differentiation of TGF-β induced regulatory T cells (iTregs), and thus, enhance anti-inflammatory effects of TGF-β In iTregs derived from EL4 T cells treated with recombinant human TGF-β1 (rhTGF-β1) in vitro, inhibition of β-catenin/TCF transcription with ICG-001 increased Foxp3 expression, interaction of β-catenin and Foxo1, binding of Foxo1 to the Foxp3 promoter, and Foxo transcriptional activity. ...Together, our results show that diversion of β-catenin from TCF- to Foxo-mediated transcription inhibits the β-catenin/TCF-mediated profibrotic effects of TGF-β while enhancing the β-catenin/Foxo-mediated anti-inflammatory effects. ...
Here, we investigated the hypothesis that we can redirect TGF-β signaling by preventing downstream profibrotic interaction of β-catenin with …
TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β
Romero M, et al. Nat Cell Biol 2018 - Clinical Trial. PMID 29593329
As a result, TP53INP2 promotes greater β-catenin levels and induces the transcriptional activity of TCF/LEF transcription factors. ...
As a result, TP53INP2 promotes greater β-catenin levels and induces the transcriptional activity of TCF/LEF transcription
Atypical Transcriptional Activation by TCF via a Zic Transcription Factor in C. elegans Neuronal Precursors.
Murgan S, et al. Dev Cell 2015. PMID 26073017 Free PMC article.
Transcription factors of the TCF family are key mediators of the Wnt/β-catenin pathway. TCF usually activates transcription on cis-regulatory elements containing TCF binding sites when the pathway is active and represses transcription when the pathway is inactive. ...This mechanism is later reinforced by specific bHLH factors. This study reveals an atypical mode of action for TCF that may apply to other binary decisions mediated by Wnt signaling....
Transcription factors of the TCF family are key mediators of the Wnt/β-catenin pathway. TCF usually activates
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