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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 2
2005 47
2006 131
2007 139
2008 143
2009 152
2010 124
2011 137
2012 151
2013 131
2014 109
2015 95
2016 96
2017 101
2018 84
2019 38
2020 0
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1,469 results
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Page 1
Wnt/beta-catenin signaling: components, mechanisms, and diseases
MacDonald BT, et al. Dev Cell 2009 - Review. PMID 19619488 Free PMC article.
Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator beta-catenin controls embryonic development and adult homeostasis. ...We also dissect critical events that regulate beta-catenin stability, from Wnt receptors to the cytoplasmic beta-catenin destruction complex, and nuclear machinery that mediates beta-catenin-dependent transcription. ...
Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator beta-catenin controls embryonic develop …
TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision.
Chen Z, et al. Immunity 2019. PMID 31606264 Free PMC article.
TCF-1 is a key transcription factor in progenitor exhausted CD8 T cells (Tex). Moreover, this Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. ...TCF-1 mediated a T-bet-to-Eomes transcription factor transition in Tex precursors by promoting Eomes expression and drove c-Myb expression that controlled Bcl-2 and survival. ...
TCF-1 is a key transcription factor in progenitor exhausted CD8 T cells (Tex). Moreover, this Tex cell subset mediates respons
Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity
Karmaus PWF, et al. Nature 2019. PMID 30568299 Free PMC article.
These two T(H)17-cell subsets are defined by selective expression of the transcription factors TCF-1 and T-bet, and by discrete levels of CD27 expression. ...T(H)17 cells with disrupted mTORC1 signalling or anabolic metabolism fail to induce autoimmune neuroinflammation or to develop into T(H)1-like cells, but instead upregulate TCF-1 expression and acquire stemness-associated features. ...
These two T(H)17-cell subsets are defined by selective expression of the transcription factors TCF-1 and T-bet, and by …
TCF/LEF dependent and independent transcriptional regulation of Wnt/β-catenin target genes.
Doumpas N, et al. EMBO J 2019. PMID 30425074 Free PMC article.
During canonical Wnt signalling, the activity of nuclear β-catenin is largely mediated by the TCF/LEF family of transcription factors. ...By performing unbiased whole transcriptome sequencing analysis, we found that a subset of β-catenin transcriptional targets did not require TCF/LEF factors for their regulation. ...
During canonical Wnt signalling, the activity of nuclear β-catenin is largely mediated by the TCF/LEF family of transcription
TCF/LEFs and Wnt signaling in the nucleus.
Cadigan KM and Waterman ML. Cold Spring Harb Perspect Biol 2012 - Review. PMID 23024173 Free PMC article.
T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end point mediators of Wnt/Wingless signaling throughout metazoans. ...In contrast to invertebrates, which typically contain one TCF/LEF protein that can both activate and repress Wnt targets, gene duplication and isoform complexity of the family in vertebrates have led to specialization, in which individual TCF/LEF isoforms have distinct activities....
T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors are the major end point mediators of Wnt/Wingles …
Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling
Cha B, et al. Cell Rep 2018. PMID 30332639 Free PMC article.
Oscillatory shear stress (OSS) enhances Wnt/β-catenin signaling in cultured lymphatic endothelial cells (LECs) to induce expression of the lymphedema-associated transcription factors GATA2 and FOXC2. ...Further, the LEC master transcription factor PROX1 forms a complex with β-catenin and the TCF/LEF transcription factor TCF7L1 to enhance Wnt/β-catenin signaling and promote FOXC2 and GATA2 expression in LECs. ...
Oscillatory shear stress (OSS) enhances Wnt/β-catenin signaling in cultured lymphatic endothelial cells (LECs) to induce expression of the l …
Tissue engineering of human hair follicles using a biomimetic developmental approach
Abaci HE, et al. Nat Commun 2018. PMID 30546011 Free PMC article.
Overexpression of Lef-1 in dermal papilla cells (DPC) restores the intact DPC transcriptional signature and significantly enhances the efficiency of HF differentiation in HSCs. ...
Overexpression of Lef-1 in dermal papilla cells (DPC) restores the intact DPC transcriptional signature and significantly enhances th …
Wnt signaling transcription factors TCF-1 and LEF-1 are upregulated in malignant astrocytic brain tumors.
Pećina-Šlaus N, et al. Histol Histopathol 2014. PMID 24858819
Since the discovery of the TCF/LEF family of transcription factors, their functions have been under intensive investigation in the area of cancer biology. The work presented in this paper focused on the changes in TCF-1 and LEF-1 expression levels in a set of astrocytic brain tumors. ...
Since the discovery of the TCF/LEF family of transcription factors, their functions have been under intensive investiga …
Human Lymph Nodes Maintain TCF-1(hi) Memory T Cells with High Functional Potential and Clonal Diversity throughout Life.
Miron M, et al. J Immunol 2018. PMID 30111633 Free PMC article.
Whole-transcriptome and high-dimensional cytometry by time-of-flight profiling reveals that LN memory CD8(+) T cells express signatures of quiescence and self-renewal compared with corresponding populations in blood, spleen, bone marrow, and lung. LN memory T cells exhibit a distinct transcriptional signature, including expression of stem cell-associated transcription factors TCF-1 and LEF-1, T follicular helper cell markers CXCR5 and CXCR4, and reduced expression of effector molecules. ...
Whole-transcriptome and high-dimensional cytometry by time-of-flight profiling reveals that LN memory CD8(+) T cells express signatur …
TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow.
Yang Q, et al. Nat Immunol 2015. PMID 26280998 Free PMC article.
We show that the transcription factor TCF-1 is required for the efficient generation of all known adult ILC subsets and their precursors. ...Our results suggest that upregulation of TCF-1 expression denotes the earliest stage of ILC fate specification. The discovery of EILPs provides a basis for deciphering additional signals that specify ILC fate....
We show that the transcription factor TCF-1 is required for the efficient generation of all known adult ILC subsets and their …
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