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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 4
1999 8
2000 105
2001 283
2002 358
2003 445
2004 474
2005 467
2006 293
2007 21
2008 15
2009 31
2010 58
2011 97
2012 105
2013 144
2014 177
2015 200
2016 214
2017 224
2018 338
2019 200
2020 4
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TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators.
Nüchel J, et al. Autophagy 2018. PMID 29297744 Free PMC article.
TGFB1 (transforming growth factor beta 1) is a potent cytokine playing a driving role in development, fibrosis and cancer. It is synthesized as prodomain-growth factor complex that requires tethering to LTBP (latent transforming growth factor beta binding protein) for efficient secretion into the extracellular space. ...Interestingly, TGFB1 secretion is fully abrogated in human and murine fibroblasts and macrophages that lack key components of the autophagic machinery. ...
TGFB1 (transforming growth factor beta 1) is a potent cytokine playing a driving role in development, fibrosis and cancer. It is synt
Simvastatin reduces TGF-β1-induced SMAD2/3-dependent human ventricular fibroblasts differentiation: Role of protein phosphatase activation.
Rizvi F, et al. Int J Cardiol 2018. PMID 30220377 Free PMC article.
Effect of simvastatin on TGF-β1-induced fibroblast activation was annulled by okadaic acid, an inhibitor of protein-phosphatase. CONCLUSIONS: This proof-of-concept study using an in vitro experimental cell culture model identifies the protective role of simvastatin against TGF-β1-induced hVF transformation into activated myofibroblasts through activation of protein phosphatase, a novel target that can be therapeutically modulated to curb excessive cardiac fibrosis associated with maladaptive cardiac remodeling....
Effect of simvastatin on TGF-β1-induced fibroblast activation was annulled by okadaic acid, an inhibitor of protein-phosphatase. CONC …
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
Woodcock HV, et al. Nat Commun 2019. PMID 30602778 Free PMC article.
The inhibitory effect of ATP-competitive mTOR inhibition extended to other matrisome proteins implicated in the development of fibrosis and human disease relevance was demonstrated in live precision-cut IPF lung slices. ...
The inhibitory effect of ATP-competitive mTOR inhibition extended to other matrisome proteins implicated in the development of fibros …
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