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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 5
1997 19
1998 23
1999 50
2000 103
2001 176
2002 201
2003 263
2004 316
2005 360
2006 341
2007 391
2008 356
2009 397
2010 419
2011 420
2012 419
2013 393
2014 343
2015 335
2016 296
2017 273
2018 226
2019 87
2020 1
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5,571 results
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Page 1
Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation.
Micheau O. Int J Mol Sci 2018 - Review. PMID 29498673 Free PMC article.
Tumor necrosis-factor related apoptosis-inducing ligand, also known as TRAIL or APO2L (Apo-2 ligand), is a cytokine of the TNF superfamily acknowledged for its ability to trigger selective apoptosis in tumor cells while being relatively safe towards normal cells. ...At the very proximal level, TRAIL DISC formation and activation of apoptosis is regulated both by antagonist receptors and by glycosylation. ...
Tumor necrosis-factor related apoptosis-inducing ligand, also known as TRAIL or APO2L (Apo-2 ligand), is …
TNF-related apoptosis-inducing ligand (TRAIL) for bone sarcoma treatment: Pre-clinical and clinical data.
Gamie Z, et al. Cancer Lett 2017 - Review. PMID 28888998
TNF-related apoptosis-inducing ligand (TRAIL), a member of the tumour necrosis factor (TNF) ligand superfamily (TNFLSF), has been found to induce apoptosis in cancer cells while sparing nontransformed cells, and may therefore offer a promising new approach to treatment. ...
TNF-related apoptosis-inducing ligand (TRAIL), a member of the tumour necrosis factor (TNF) lig
The role of XIAP in resistance to TNF-related apoptosis-inducing ligand (TRAIL) in Leukemia.
Saraei R, et al. Biomed Pharmacother 2018 - Review. PMID 30257312
TNF-related apoptosis-inducing ligand (TRAIL) represents a targeted therapy against cancer because it induces apoptosis only in tumor cells. ...In a variety of leukemic cells, overexpression of X-linked inhibitor of apoptosis protein (XIAP), a negative regulator of apoptosis pathway, has been discovered. ...
TNF-related apoptosis-inducing ligand (TRAIL) represents a targeted therapy against cancer because it ind
Comprehensive expression analysis of TNF-related apoptosis-inducing ligand and its receptors in colorectal cancer: Correlation with MAPK alterations and clinicopathological associations.
Tsikalakis S, et al. Pathol Res Pract 2018. PMID 29731264
TNF-related, apoptosis-inducing ligand (TRAIL) apoptotic pathway constitutes a promising therapeutic target due to high selectivity and low toxicity of TRAIL targeting agents when administered in combination therapies. 106 colorectal cancers were examined for: relative mRNA expression of TRAIL pathway genes, decoy receptors TRAIL-R3 and TRAIL-R4 promoter methylation and the presence of KRAS, NRAS, BRAF mutations. ...
TNF-related, apoptosis-inducing ligand (TRAIL) apoptotic pathway constitutes a promising therapeutic targ
TNF-related apoptosis-inducing ligand (TRAIL) in rheumatoid arthritis: what's new?
Neve A, et al. Clin Exp Med 2014 - Review. PMID 23275079
TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein of the TNF superfamily that serves as an extracellular signal that triggers programmed cell death in tumor cells, without affecting normal cells. ...The impact of TRAIL molecular variants and agonistic monoclonal antibodies in the regulation of TRAIL activity in arthritis animal models strongly supports the idea of testing the role of TRAIL in humans, with the aim of developing new effective therapies that promote apoptosis of synoviocytes and/or infiltrating lymphocytes, by targeting TRAIL. ...
TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein of the TNF superf
Distinct roles of TNF-related apoptosis-inducing ligand (TRAIL) in viral and bacterial infections: from pathogenesis to pathogen clearance.
Gyurkovska V and Ivanovska N. Inflamm Res 2016 - Review. PMID 26943649
Tumor necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein belonging to the TNF superfamily, which is involved not only in tumor growth suppression but in infection control and also in the regulation of both innate and adaptive immune responses. ...CONCLUSION: Present data highlight an essential role for the TRAIL/TRAIL-R system in the regulation and modulation of apoptosis and show that TRAIL has distinct roles in pathogenesis and pathogen elimination. ...
Tumor necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein …
Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy
von Karstedt S, et al. Nat Rev Cancer 2017 - Review. PMID 28536452
The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study of pro-apoptotic TRAIL receptor (TRAIL-R) signalling and the development of biotherapeutic drug candidates that activate TRAIL-Rs. ...
The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis
Tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL).
Fulda S. Adv Exp Med Biol 2014 - Review. PMID 25001536
Among the death receptor superfamily, the tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL) receptor/ligand system is of special interest. ...
Among the death receptor superfamily, the tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL) recept …
Developing TRAIL/TRAIL death receptor-based cancer therapies
Yuan X, et al. Cancer Metastasis Rev 2018 - Review. PMID 29541897 Free PMC article.
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of the TRAIL pathway in inducing tumor-selective apoptosis leads to the development of TRAIL-based cancer therapies, which include recombinant forms of TRAIL, TRAIL receptor agonists, and other therapeutic agents. ...
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF super …
Redox signaling and oxidative stress: Cross talk with TNF-related apoptosis inducing ligand activity.
Voltan R, et al. Int J Biochem Cell Biol 2016 - Review. PMID 27686849 Free article.
In this light, there is also growing attention to the involvement of this link in the activity of the TNF-related apoptosis inducing ligand (TRAIL). TRAIL is a member of the TNF ligands super family able to mediate multiple intracellular signals, with the potential to lead to a range of biological effects in different cell types. ...
In this light, there is also growing attention to the involvement of this link in the activity of the TNF-related apoptosis
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