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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 5
1997 19
1998 23
1999 50
2000 103
2001 176
2002 201
2003 263
2004 316
2005 360
2006 341
2007 391
2008 356
2009 397
2010 419
2011 420
2012 419
2013 393
2014 343
2015 335
2016 296
2017 273
2018 226
2019 87
2020 1
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5,571 results
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Page 1
Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation.
Micheau O. Int J Mol Sci 2018 - Review. PMID 29498673 Free PMC article.
Tumor necrosis-factor related apoptosis-inducing ligand, also known as TRAIL or APO2L (Apo-2 ligand), is a cytokine of the TNF superfamily acknowledged for its ability to trigger selective apoptosis in tumor cells while being relatively safe towards normal cells. ...At the very proximal level, TRAIL DISC formation and activation of apoptosis is regulated both by antagonist receptors and by glycosylation. ...
Tumor necrosis-factor related apoptosis-inducing ligand, also known as TRAIL or APO2L (Apo-2 ligand), is …
TNF-related apoptosis-inducing ligand (TRAIL) as the potential therapeutic target in hematological malignancies.
Naimi A, et al. Biomed Pharmacother 2018 - Review. PMID 29288972
TNF-related apoptosis-inducing ligand (TRAIL), a member of TNF superfamily, has significantly attracted the researchers to use it as an effective treatment strategy for cancer since it can preferentially induce apoptosis in a variety of primary tumor cells without affecting the adjacent normal cells. ...Hence, we have tried to summarize the TRAIL-related therapies as a potential therapeutic option in hematological malignancies....
TNF-related apoptosis-inducing ligand (TRAIL), a member of TNF superfamily, has significantly attr
TNF-related apoptosis-inducing ligand (TRAIL) for bone sarcoma treatment: Pre-clinical and clinical data.
Gamie Z, et al. Cancer Lett 2017 - Review. PMID 28888998
TNF-related apoptosis-inducing ligand (TRAIL), a member of the tumour necrosis factor (TNF) ligand superfamily (TNFLSF), has been found to induce apoptosis in cancer cells while sparing nontransformed cells, and may therefore offer a promising new approach to treatment. ...
TNF-related apoptosis-inducing ligand (TRAIL), a member of the tumour necrosis factor (TNF) lig
The role of XIAP in resistance to TNF-related apoptosis-inducing ligand (TRAIL) in Leukemia.
Saraei R, et al. Biomed Pharmacother 2018 - Review. PMID 30257312
TNF-related apoptosis-inducing ligand (TRAIL) represents a targeted therapy against cancer because it induces apoptosis only in tumor cells. ...In a variety of leukemic cells, overexpression of X-linked inhibitor of apoptosis protein (XIAP), a negative regulator of apoptosis pathway, has been discovered. ...
TNF-related apoptosis-inducing ligand (TRAIL) represents a targeted therapy against cancer because it ind
Effects of Recombinant Circularly Permuted Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) (Recombinant Mutant Human TRAIL) in Combination with 5-Fluorouracil in Human Colorectal Cancer Cell Lines HCT116 and SW480.
Sun T, et al. Med Sci Monit 2018. PMID 29695684 Free PMC article.
BACKGROUND Circularly permuted tumor necrosis factor-related apoptosis-inducing ligand, a mutant form of tumor necrosis factor-related apoptosis-inducing ligand, is an effective antitumor cytokine. ...Furthermore, the levels of apoptosis-related proteins were examined by Western blotting. RESULTS Compared to either agent alone, cotreatment with 5-fluorouracil and circularly permuted tumor necrosis factor-related apoptosis-inducing ligand showed obvious antitumor effects and induced significant apoptosis of colorectal cancer cells. 5-Fluorouracil enhanced circularly permuted tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by increasing death receptor 4 and 5 levels in HCT116 cells, but only of death receptor 4 in SW480 cells. ...
BACKGROUND Circularly permuted tumor necrosis factor-related apoptosis-inducing ligand, a mutant form of tumor n …
Trail (TNF-related apoptosis-inducing ligand) induces an inflammatory response in human adipocytes.
Zoller V, et al. Sci Rep 2017. PMID 28720906 Free PMC article.
High serum concentrations of TNF-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor protein family, are found in patients with increased BMI and serum lipid levels. ...It stimulates the expression of interleukin 6 (IL-6), interleukin 8 (IL-8) as well as the chemokines monocyte chemoattractant protein-1 (MCP-1) and chemokine C-C motif ligand 20 (CCL-20) in a time- and dose-dependent manner. ...
High serum concentrations of TNF-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosi …
Comprehensive expression analysis of TNF-related apoptosis-inducing ligand and its receptors in colorectal cancer: Correlation with MAPK alterations and clinicopathological associations.
Tsikalakis S, et al. Pathol Res Pract 2018. PMID 29731264
TNF-related, apoptosis-inducing ligand (TRAIL) apoptotic pathway constitutes a promising therapeutic target due to high selectivity and low toxicity of TRAIL targeting agents when administered in combination therapies. 106 colorectal cancers were examined for: relative mRNA expression of TRAIL pathway genes, decoy receptors TRAIL-R3 and TRAIL-R4 promoter methylation and the presence of KRAS, NRAS, BRAF mutations. ...
TNF-related, apoptosis-inducing ligand (TRAIL) apoptotic pathway constitutes a promising therapeutic targ
ML327 induces apoptosis and sensitizes Ewing sarcoma cells to TNF-related apoptosis-inducing ligand.
Rellinger EJ, et al. Biochem Biophys Res Commun 2017. PMID 28716733 Free PMC article.
Epithelial-to-mesenchymal transition in epithelial carcinomas is associated with loss of E-cadherin and resistance to apoptosis. ...Herein, we sought to evaluate the effects of ML327 on mesenchymal-derived Ewing sarcoma cells, hypothesizing that ML327 initiates growth arrest and sensitizes to TNF-related apoptosis-inducing ligand. ...
Epithelial-to-mesenchymal transition in epithelial carcinomas is associated with loss of E-cadherin and resistance to apoptosis. ...H …
The long non-coding RNA HOTAIR enhances pancreatic cancer resistance to TNF-related apoptosis-inducing ligand.
Yang SZ, et al. J Biol Chem 2017. PMID 28476883 Free PMC article.
Therapeutic agents that activate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis have shown promising efficacy, but many pancreatic cancers are resistant to TRAIL therapy. ...Overexpressing HOTAIR in TRAIL-sensitive cells attenuated TRAIL-induced apoptosis, and shRNA-mediated HOTAIR knockdown in TRAIL-resistant PANC-1 cells sensitized them to TRAIL-induced apoptosis. ...
Therapeutic agents that activate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis h …
Serum TNF-related weak inducer of apoptosis (TWEAK) and TNF-related apoptosis-inducing ligand (TRAIL) levels of patients with bipolar disorder in manic episode, in remission and healthy controls.
Cingi Yirün M, et al. Psychiatry Res 2017. PMID 28800513
TNF-related weak inducer of apoptosis (TWEAK) and TNF-related apoptosis-inducing ligand (TRAIL) are members of TNF superfamily, which has various roles in immunologic and inflammatory reactions in the organism. ...Studies having larger samples and limited confounders are needed to be able to evaluate these changes better and detect possible alterations about TRAIL and other TNF superfamily members....
TNF-related weak inducer of apoptosis (TWEAK) and TNF-related apoptosis-inducing ligand
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