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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
2007 1
2008 1
2009 14
2010 389
2011 903
2012 1179
2013 1544
2014 1618
2015 1796
2016 1813
2017 1887
2018 1893
2019 849
2020 16
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12,102 results
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Page 1
mTOR Signaling in Growth, Metabolism, and Disease.
Saxton RA and Sabatini DM. Cell 2017 - Review. PMID 28283069 Free PMC article.
The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors. ...
The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nut …
mTOR signalling and cellular metabolism are mutual determinants in cancer.
Mossmann D, et al. Nat Rev Cancer 2018 - Review. PMID 30425336
Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR, which is frequently activated in cancer, controls cell growth and metabolism. mTOR signalling regulates amino acid, glucose, nucleotide, fatty acid and lipid metabolism. ...In this Review, we discuss how mTOR signalling rewires cancer cell metabolism and delineate how changes in metabolism, in turn, sustain mTOR signalling and tumorigenicity. ...
Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR, which is frequently activated in cancer, controls cel …
mTORC1 signaling and the metabolic control of cell growth
Ben-Sahra I and Manning BD. Curr Opin Cell Biol 2017 - Review. PMID 28411448 Free PMC article.
mTOR [mechanistic target of rapamycin] is a serine/threonine protein kinase that, as part of mTORC1 (mTOR complex 1), acts as an important molecular connection between nutrient signals and the metabolic processes indispensable for cell growth. ...
mTOR [mechanistic target of rapamycin] is a serine/threonine protein kinase that, as part of mTORC1 (mTOR complex 1), acts as …
Molecular neurobiology of mTOR
Switon K, et al. Neuroscience 2017 - Review. PMID 27889578 Free article.
Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that controls several important aspects of mammalian cell function. mTOR activity is modulated by various intra- and extracellular factors; in turn, mTOR changes rates of translation, transcription, protein degradation, cell signaling, metabolism, and cytoskeleton dynamics. mTOR has been repeatedly shown to participate in neuronal development and the proper functioning of mature neurons. ...
Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that controls several important aspects of mamma …
Nutrient sensing and TOR signaling in yeast and mammals.
González A and Hall MN. EMBO J 2017 - Review. PMID 28096180 Free PMC article.
The evolutionarily conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in particular amino acids. ...Here, we review how nutrient availability is sensed and transduced to TOR in budding yeast and mammals. A better understanding of how nutrient availability is transduced to TOR may allow novel strategies in the treatment for mTOR-related diseases....
The evolutionarily conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in particular amino acids. ...H …
The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling
Yoon MS. Nutrients 2017 - Review. PMID 29077002 Free PMC article.
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls a wide spectrum of cellular processes, including cell growth, differentiation, and metabolism. mTOR forms two distinct multiprotein complexes known as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), which are characterized by the presence of raptor and rictor, respectively. mTOR controls insulin signaling by regulating several downstream components such as growth factor receptor-bound protein 10 (Grb10), insulin receptor substrate (IRS-1), F-box/WD repeat-containing protein 8 (Fbw8), and insulin like growth factor 1 receptor/insulin receptor (IGF-IR/IR). ...This review outlines the current understanding of mTOR regulation in insulin signaling in the context of whole body metabolism....
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls a wide spectrum of cellular processes, inc …
mTOR: from growth signal integration to cancer, diabetes and ageing
Zoncu R, et al. Nat Rev Mol Cell Biol 2011 - Review. PMID 21157483 Free PMC article.
In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and nutrient abundance to the execution of cell growth and division, owing to the ability of TOR protein kinase to simultaneously sense energy, nutrients and stress and, in metazoans, growth factors. Mammalian TOR complex 1 (mTORC1) and mTORC2 exert their actions by regulating other important kinases, such as S6 kinase (S6K) and Akt. ...
In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and nutrient abundance to the execution of cell gr …
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