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TSPAN31 Activates Fatty Acid Metabolism and PI3K/AKT Pathway to Promote Tumor Progression in Breast Cancer.
Luo W, Sun Y, Cao L. Luo W, et al. Mol Carcinog. 2025 Jun;64(6):1078-1089. doi: 10.1002/mc.23912. Epub 2025 Mar 26. Mol Carcinog. 2025. PMID: 40135650
Investigation of the function and potential mechanism of TSPAN31 in BC was the purpose of this study. Immunohistochemistry, western blot, and quantitative real-time polymerase chain reaction were applied to measure TSPAN31 expression. ...In contrast, TSPAN31
Investigation of the function and potential mechanism of TSPAN31 in BC was the purpose of this study. Immunohistochemistry, western b …
TSPAN31 is a critical regulator on transduction of survival and apoptotic signals in hepatocellular carcinoma cells.
Wang J, Zhou Y, Li D, Sun X, Deng Y, Zhao Q. Wang J, et al. FEBS Lett. 2017 Sep;591(18):2905-2918. doi: 10.1002/1873-3468.12737. Epub 2017 Sep 7. FEBS Lett. 2017. PMID: 28670683 Free article.
Target analysis indicates that miR-135b can directly regulate TSPAN31 expression. miR-135b-induced TSPAN31 silencing increases CDK4 protein levels. Interestingly, p53 negatively regulates TSPAN31 expression. siRNA-induced TSPAN31 knockdown reduces the …
Target analysis indicates that miR-135b can directly regulate TSPAN31 expression. miR-135b-induced TSPAN31 silencing increases …
Overexpression of Tetraspanin31 contributes to malignant potential and poor outcomes in gastric cancer.
Takashima Y, Komatsu S, Ohashi T, Kiuchi J, Kamiya H, Shimizu H, Arita T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Tsuda H, Otsuji E. Takashima Y, et al. Cancer Sci. 2022 Jun;113(6):1984-1998. doi: 10.1111/cas.15342. Epub 2022 Apr 1. Cancer Sci. 2022. PMID: 35307915 Free PMC article.
We tested whether TSPAN31 acts as a cancer-promoting gene through its activation or overexpression in GC. ...In vivo analysis also revealed knockdown of TSPAN31 suppressed tumor progression. In addition, knockdown of TSPAN31 improved chemosensitivity to cispl …
We tested whether TSPAN31 acts as a cancer-promoting gene through its activation or overexpression in GC. ...In vivo analysis also re …
The molecular landscape of well differentiated retroperitoneal liposarcoma.
Tyler R, Dilworth MP, James J, Blakeway D, Stockton JD, Morton DG, Taniere P, Gourevitch D, Desai A, Beggs AD. Tyler R, et al. J Pathol. 2021 Oct;255(2):132-140. doi: 10.1002/path.5749. Epub 2021 Aug 4. J Pathol. 2021. PMID: 34156092
Recurrent gene fusions in HGMA2, SDHA, TSPAN31, and MDM2 were also observed as well as consistent rearrangements between chromosome 6 and chromosome 12. ...
Recurrent gene fusions in HGMA2, SDHA, TSPAN31, and MDM2 were also observed as well as consistent rearrangements between chromosome 6 …
Carboxypeptidase M: a biomarker for the discrimination of well-differentiated liposarcoma from lipoma.
Erickson-Johnson MR, Seys AR, Roth CW, King AA, Hulshizer RL, Wang X, Asmann YW, Lloyd RV, Jacob EK, Oliveira AM. Erickson-Johnson MR, et al. Mod Pathol. 2009 Dec;22(12):1541-7. doi: 10.1038/modpathol.2009.149. Epub 2009 Oct 9. Mod Pathol. 2009. PMID: 19820690 Free article.
These abnormal chromosomes are mainly composed of amplified genomic sequences derived from chromosome 12q13-15, and contain several genes, including MDM2, CDK4 (SAS), TSPAN31, HMGA2, and others. MDM2 is consistently amplified in well-differentiated liposarcomas/atypical li …
These abnormal chromosomes are mainly composed of amplified genomic sequences derived from chromosome 12q13-15, and contain several genes, i …
TSPAN31 suppresses cell proliferation in human cervical cancer through down-regulation of its antisense pairing with CDK4.
Xia Y, Deng Y, Zhou Y, Li D, Sun X, Gu L, Chen Z, Zhao Q. Xia Y, et al. Cell Biochem Funct. 2020 Jul;38(5):660-668. doi: 10.1002/cbf.3526. Epub 2020 Mar 23. Cell Biochem Funct. 2020. PMID: 32207169
Furthermore, silencing the expression of the TSPAN31 mRNA rescued the TSPAN31 3'-UTR- or the TSPAN31 full-length-induced decrease in CDK4 expression. ...Therefore, TSPAN31 and CDK4 have great significance in the study of tumour therapeutic targets....
Furthermore, silencing the expression of the TSPAN31 mRNA rescued the TSPAN31 3'-UTR- or the TSPAN31 full-length-induce …
Construction and validation of a 6-gene nomogram discriminating lung metastasis risk of breast cancer patients.
Wang L, Wang W, Zeng S, Zheng H, Lu Q. Wang L, et al. PLoS One. 2020 Dec 30;15(12):e0244693. doi: 10.1371/journal.pone.0244693. eCollection 2020. PLoS One. 2020. PMID: 33378415 Free PMC article.
The best genes for modeling were selected using a robust likelihood-based survival modeling approach: GOLGB1, TMEM158, CXCL8, MCM5, HIF1AN, and TSPAN31. A prognostic nomogram for predicting lung metastasis in breast cancer was developed based on these six genes. ...
The best genes for modeling were selected using a robust likelihood-based survival modeling approach: GOLGB1, TMEM158, CXCL8, MCM5, HIF1AN, …
TSPAN31 Activates EMT Through the PI3 K/AKT Signaling Pathway to Promote Glioma Progression.
Tong H, Zhang A, Shi Y, Zhu S, Liu L. Tong H, et al. Neurochem Res. 2025 Jun 9;50(3):192. doi: 10.1007/s11064-025-04439-2. Neurochem Res. 2025. PMID: 40488790
Pan-cancer analysis was performed to evaluate TSPAN31's prognostic value through Kaplan-Meier survival curves and ROC analysis. TSPAN31 expression in glioma tissues and cell lines was quantified via Western blot and qRT-PCR. ...These findings provide mechanistic ins …
Pan-cancer analysis was performed to evaluate TSPAN31's prognostic value through Kaplan-Meier survival curves and ROC analysis. TS
Characterization of the 12q amplicons in lipomatous soft tissue tumors by multiplex ligation-dependent probe amplification-based copy number analysis.
Creytens D, Van Gorp J, Speel EJ, Ferdinande L. Creytens D, et al. Anticancer Res. 2015 Apr;35(4):1835-42. Anticancer Res. 2015. PMID: 25862836
RESULTS: We recorded several amplified genes of 12q13-15, including miR-26a-2, a gene not well studied in liposarcoma, and the well-known and previously described genes murine double minute 2 (MDM2), YEATS domain-containing protein 4 (YEATS4), high-mobility AT-hook 2 (HMGA2), cyc …
RESULTS: We recorded several amplified genes of 12q13-15, including miR-26a-2, a gene not well studied in liposarcoma, and the well-known an …
Identification of a novel gene signature predicting response to first-line chemotherapy in BRCA wild-type high-grade serous ovarian cancer patients.
Buttarelli M, Ciucci A, Palluzzi F, Raspaglio G, Marchetti C, Perrone E, Minucci A, Giacò L, Fagotti A, Scambia G, Gallo D. Buttarelli M, et al. J Exp Clin Cancer Res. 2022 Feb 4;41(1):50. doi: 10.1186/s13046-022-02265-w. J Exp Clin Cancer Res. 2022. PMID: 35120576 Free PMC article.
The ten-gene signature included: CKB (Creatine kinase B), CTNNBL1 (Catenin, beta like 1), GNG11 (G protein subunit gamma 11), IGFBP7 (Insulin-like growth factor-binding protein 7), PLCG2 (Phospholipase C, gamma 2), RNF24 (Ring finger protein 24), SLC15A3 (Solute carrier family 15 …
The ten-gene signature included: CKB (Creatine kinase B), CTNNBL1 (Catenin, beta like 1), GNG11 (G protein subunit gamma 11), IGFBP7 (Insuli …
26 results