Clinical findings of three siblings with Peters' anomaly and congenital heart disease, and histopathological findings of the second child were reported. These three cases all underwent operation for secondary glaucoma. Schlemm's canal was not observed in the first and second child. Autosomal recessive inheritance was considered the possible cause. As for the mechanism by which this disease is produced, it is surmised that abnormal development of the eye is caused by hypoxia due to ophthalmic circulatory insufficiency in the embryogenic period, and that the already formed lens shifts forward causing this disease, judging from the fact that there was severe tetralogy of Fallot in the first and the third case, and VSD + PDA in the second case, and from the histopathological findings.