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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1959 14
1960 8
1961 9
1962 7
1965 4
1966 2
1967 7
1968 3
1969 1
1970 8
1971 3
1972 3
1973 1
1974 1
1975 7
1976 4
1977 4
1978 1
1979 1
1980 2
1981 2
1982 2
1983 3
1984 4
1986 3
1988 4
1989 4
1990 5
1991 8
1992 9
1993 10
1994 10
1995 18
1996 19
1997 13
1998 15
1999 31
2000 25
2001 37
2002 37
2003 48
2004 43
2005 55
2006 71
2007 81
2008 77
2009 73
2010 81
2011 94
2012 82
2013 98
2014 105
2015 106
2016 100
2017 102
2018 90
2019 42
2020 0
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1,469 results
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Page 1
Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes.
Rochette L, et al. Can J Physiol Pharmacol 2015 - Review. PMID 26406389
Alpha-lipoic acid (LA) possesses beneficial effects both in the prevention and in the treatment of diabetes. LA is a potent antioxidant with insulin-mimetic and anti-inflammatory activity. LA in the diet is quickly absorbed, transported to the intracellular compartments, and reduced to dihydrolipoic acid (DHLA) under the action of enzymes. ...
Alpha-lipoic acid (LA) possesses beneficial effects both in the prevention and in the treatment of diabetes. LA is a potent antioxida …
Physiological effect and therapeutic application of alpha lipoic acid.
Park S, et al. Curr Med Chem 2014 - Review. PMID 25005184
Consequently, many biological effects of α-lipoic acid supplementation can be attributed to the potent antioxidant properties of α-lipoic acid and dihydro α-lipoic acid. ...Although healthy young humans can synthesize enough α-lipoic acid to scavenge reactive oxygen species and enhance endogenous antioxidants like glutathione and vitamins C and E, the level of α-lipoic acid significantly declines with age and this may lead to endothelial dysfunction. ...
Consequently, many biological effects of α-lipoic acid supplementation can be attributed to the potent antioxidant properties of α-li …
Lack of a Clinically Significant Pharmacokinetic Interaction Between Pregabalin and Thioctic Acid in Healthy Volunteers.
Rhee SJ, et al. Clin Ther 2018 - Clinical Trial. PMID 30241687
The volunteers randomly received pregabalin 300 mg BID for 6 times, thioctic acid 600 mg once daily for 3 times, or the combination of pregabalin and thioctic acid. ...Co-administered pregabalin and thioctic acid was well tolerated. IMPLICATIONS: Repeatedly administered pregabalin and thioctic acid do not interact pharmacokinetically. ...
The volunteers randomly received pregabalin 300 mg BID for 6 times, thioctic acid 600 mg once daily for 3 times, or the combin …
Alpha lipoic acid in obstetrics and gynecology.
Di Tucci C, et al. Gynecol Endocrinol 2018 - Review. PMID 29726290
Alpha-Lipoic acid (ALA) is a natural antioxidant synthetized by plants and animals, identified as a catalytic agent for oxidative decarboxylation of pyruvate and α-ketoglutarate. ...The association of N-acetyl cysteine (NAC), alpha-lipoic acid (ALA), and bromelain (Br) is used for prevention and treatment of endometriosis. ...
Alpha-Lipoic acid (ALA) is a natural antioxidant synthetized by plants and animals, identified as a catalytic agent for oxidative dec …
Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway.
Estrada DE, et al. Diabetes 1996. PMID 8922368
Thioctic acid (alpha-lipoic acid), a natural cofactor in dehydrogenase complexes, is used in Germany in the treatment of symptoms of diabetic neuropathy. ...The aim of this study was to determine the direct effect of thioctic acid on glucose uptake and glucose transporters. In L6 muscle cells and 3T3-L1 adipocytes in culture, glucose uptake was rapidly increased by (R)-thioctic acid. ...
Thioctic acid (alpha-lipoic acid), a natural cofactor in dehydrogenase complexes, is used in Germany in the treatment o
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Shay KP, et al. Biochim Biophys Acta 2009 - Review. PMID 19664690 Free PMC article.
Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well-defined as a therapy for preventing diabetic polyneuropathies, and scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age. ...LA and its reduced form, dihydrolipoic acid, may use their chemical properties as a redox couple to alter protein conformations by forming mixed disulfides. ...
Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well …
In vitro effects of vitamin C, thioctic acid and dihydrolipoic acid on the cytotoxicity of post-ethanol serum.
Wickramasinghe SN and Hasan R. Biochem Pharmacol 1992. PMID 1540197
When post-alcohol sera are incubated for 3 hr with ascorbic acid, thioctic acid or dihydrolipoic acid at a concentration of 10-500 micrograms/mL, their cytotoxicity against A9 cells is reduced. Post-alcohol sera incubated with these concentrations of thioctic acid or dihydrolipoic acid also had reduced cytotoxic activity against phytohaemagglutinin-transformed normal human lymphocytes. ...
When post-alcohol sera are incubated for 3 hr with ascorbic acid, thioctic acid or dihydrolipoic acid at a conce …
Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA.
El-Shitany NA, et al. Fundam Clin Pharmacol 2010. PMID 19735303
Thioctic acid (200 mg/kg) reduced both paw edema formation and lymphocytes infiltration more significant than indomethacin itself: Both thioctic acid and indomethacin reduced paw MDA and NO formation. ...Thioctic acid decreased the elevated COX-2 mRNA while indomethacin, failed. Furthermore, thioctic acid increased IL-10 mRNA expression while indomethacin decreased its expression. ...
Thioctic acid (200 mg/kg) reduced both paw edema formation and lymphocytes infiltration more significant than indomethacin its
α-Lipoic acid inhibits the migration and invasion of breast cancer cells through inhibition of TGFβ signaling.
Tripathy J, et al. Life Sci 2018. PMID 29802942
However, the effect of lipoic acid on breast cancer metastasis remains unclear. MAIN METHODS: In the present study, we examined the effects of lipoic acid on the migration and invasion of MDA-MB-231 and 4T1 breast cancer cells. ...Thus, our findings show that the inhibition of TGFβ signaling is a potential mechanism for the anti-invasive effects of lipoic acid....
However, the effect of lipoic acid on breast cancer metastasis remains unclear. MAIN METHODS: In the present study, we examined the e …
1,469 results
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