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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 13
1998 41
1999 69
2000 65
2001 76
2002 90
2003 101
2004 97
2005 111
2006 113
2007 97
2008 130
2009 116
2010 115
2011 116
2012 117
2013 110
2014 102
2015 111
2016 91
2017 97
2018 68
2019 32
2020 0
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1,880 results
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Page 1
Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease.
Murphy-Ullrich JE and Suto MJ. Matrix Biol 2018 - Review. PMID 29288716 Free PMC article.
In this review, we will discuss the role of the matricellular protein, thrombospondin 1 (TSP-1), in regulation of latent TGF-β activation and the use of an antagonist of TSP-1 mediated TGF-β activation in a number of diverse fibrotic diseases. ...As TSP-1 expression is upregulated by factors induced in fibrotic disease, targeting the TSP-1/TGF-β pathway potentially represents a more selective approach to controlling TGF-β activity in disease....
In this review, we will discuss the role of the matricellular protein, thrombospondin 1 (TSP-1), in regulation of laten …
Secreted Thrombospondin-1 Regulates Macrophage Interleukin-1β Production and Activation through CD47.
Stein EV, et al. Sci Rep 2016. PMID 26813769 Free PMC article.
This inhibition can be explained by the ability of thrombospondin-1 to disrupt the interaction between CD47 and CD14, thereby limiting activation of NFκB/AP-1 by lipopolysaccharide. Only the CD47-binding domain of thrombospondin-1 exhibits this activity. In contrast, CD47, CD36, and integrin-binding domains of thrombospondin-1 independently enhance the inflammasome-dependent maturation of IL-1β in human THP-1 monocyte-derived macrophages. ...
This inhibition can be explained by the ability of thrombospondin-1 to disrupt the interaction between CD47 and CD14, thereby …
Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells.
Bray ER, et al. Neuron 2019. PMID 31255486 Free PMC article.
Strikingly, thrombospondin-1 (Thbs1) ranked as the most differentially expressed gene, along with the well-documented injury-response genes Atf3 and Jun. ...Conversely, RGC overexpression of THBS1 enhanced regeneration in both ipRGCs and non-ipRGCs, an effect that was dependent on syndecan-1, a known THBS1-binding protein. ...
Strikingly, thrombospondin-1 (Thbs1) ranked as the most differentially expressed gene, along with the well-documented injury-r …
Thrombospondin-1 Is Necessary for the Development and Repair of Corneal Nerves.
Tatematsu Y, et al. Int J Mol Sci 2018. PMID 30332778 Free PMC article.
Thrombospondin-1-deficient (TSP-1(-/-)) mice are used as an animal model of Sjögren's Syndrome because they exhibit many of the symptoms associated with the autoimmune type of dry eye found in primary Sjögren's Syndrome. ...We found that only the pro-inflammatory cytokine MIP-2 increased in young corneas of TSP-1(-/-) compared to WT mice, but tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-2 (MIP-2) all increased in older TSP-1(-/-) mouse corneas. ...
Thrombospondin-1-deficient (TSP-1(-/-)) mice are used as an animal model of Sjögren's Syndrome because they exhibit man
Thrombospondin-1-Based Antiangiogenic Therapy.
Sims JN and Lawler J. J Ocul Pharmacol Ther 2015. PMID 26352160 Free PMC article.
A complementary approach would be to increase the level of naturally occurring inhibitors of angiogenesis, such as thrombospondin (TSP)-1. This article summarizes the development of TSP-1-based inhibitors of angiogenesis....
A complementary approach would be to increase the level of naturally occurring inhibitors of angiogenesis, such as thrombospondin (TS …
Thrombospondin-1 Production Regulates the Inflammatory Cytokine Secretion in THP-1 Cells Through NF-κB Signaling Pathway.
Xing T, et al. Inflammation 2017. PMID 28634844
Thrombospondin-1 (TSP-1) is upregulated in several inflammatory diseases. Recent data have shown that macrophages from TSP-1-deficient mice have a reduced inflammatory phenotype, suggesting that TSP-1 plays a part in macrophage activation. ...Deficiency of TSP-1 by transfecting siRNAs decreased IL-6, IL-1β, and TNF-α secretions in THP-1 cells, whereas overexpression of TSP-1 resulted in an upregulation of IL-6, IL-1β, and TNF-α productions. ...
Thrombospondin-1 (TSP-1) is upregulated in several inflammatory diseases. Recent data have shown that macrophages from
Neutrophil-Mediated Proteolysis of Thrombospondin-1 Promotes Platelet Adhesion and String Formation.
Seif K, et al. Thromb Haemost 2018. PMID 30419595 Free PMC article.
Thrombospondin-1 (TSP-1) is primarily expressed by platelets and endothelial cells (ECs) and rapidly released upon their activation. ...We hypothesized that TSP-1 processing may alter its haemostatic properties. Selective enzyme inhibitors in co-cultures revealed that neutrophil proteases elastase and cathepsin G mediate TSP-1 processing. ...
Thrombospondin-1 (TSP-1) is primarily expressed by platelets and endothelial cells (ECs) and rapidly released upon thei
Role of Thrombospondin-1 in Mechanotransduction and Development of Thoracic Aortic Aneurysm in Mouse and Humans.
Yamashiro Y, et al. Circ Res 2018. PMID 30355232 Free PMC article.
In this mouse, upregulation of Egr1 (early growth response 1) and angiotensin-converting enzyme leads to activation of Ang II (angiotensin II) signaling. Here, we showed that the matricellular protein, Thbs1 (thrombospondin-1), was highly upregulated in SMKO ascending aortas and in human thoracic aortic aneurysms. ...
In this mouse, upregulation of Egr1 (early growth response 1) and angiotensin-converting enzyme leads to activation of Ang II (angiot …
Thrombospondin-1 and Pathogenesis of Age-Related Macular Degeneration.
Housset M and Sennlaub F. J Ocul Pharmacol Ther 2015 - Review. PMID 26062001
Thrombospondin-1 (TSP-1) is a major matricellular protein that is physiologically expressed in the RPE and choroid, but severely diminished in eyes with AMD. ...We here give an overview of the major functions of TSP-1 and how it could intervene in AMD pathogenesis....
Thrombospondin-1 (TSP-1) is a major matricellular protein that is physiologically expressed in the RPE and choroid, but
Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome.
Torres MD, et al. Free Radic Biol Med 2018 - Review. PMID 28965914
Here we briefly examine the role of astrocytes in spine alterations and more specifically the involvement of astrocyte-secreted thrombospondin 1 (TSP-1) deficits in spine and synaptic pathology in DS....
Here we briefly examine the role of astrocytes in spine alterations and more specifically the involvement of astrocyte-secreted thrombosp
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