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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 3
1947 3
1948 4
1949 4
1950 5
1951 3
1952 4
1953 5
1954 3
1955 3
1956 2
1957 8
1958 12
1959 7
1960 5
1961 12
1962 8
1963 7
1964 15
1965 8
1966 4
1967 7
1968 1
1969 1
1970 3
1971 6
1972 1
1973 1
1974 11
1975 6
1976 19
1977 372
1978 1026
1979 1191
1980 1211
1981 1206
1982 1541
1983 1715
1984 1979
1985 1929
1986 2077
1987 1798
1988 1501
1989 1593
1990 1637
1991 1654
1992 1821
1993 2023
1994 2331
1995 2333
1996 2391
1997 2326
1998 2275
1999 2769
2000 2896
2001 3569
2002 3133
2003 2986
2004 3050
2005 2932
2006 2689
2007 2590
2008 2425
2009 2228
2010 2261
2011 2334
2012 2461
2013 2270
2014 2365
2015 2465
2016 2387
2017 2319
2018 2243
2019 1138
2020 21
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86,246 results
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Page 1
Pharmacokinetics
Fan J and de Lannoy IA. Biochem Pharmacol 2014 - Review. PMID 24055064
Pharmacokinetics (PK) is the study of the time course of the absorption, distribution, metabolism and excretion (ADME) of a drug, compound or new chemical entity (NCE) after its administration to the body. ...Compound absorption and permeability are discussed in the context of intestinal absorption and brain penetration. The volume of distribution and plasma protein and tissue binding are covered as is the clearance (systemic, hepatic, renal, biliary) of both small and large molecules. ...
Pharmacokinetics (PK) is the study of the time course of the absorption, distribution, metabolism and excretion (ADME) of a drug, com …
Pharmacokinetics and tissue distribution of eupatilin and its metabolite in rats by an HPLC-MS/MS method.
Wang X, et al. J Pharm Biomed Anal 2018. PMID 29980012
The validated method was then successfully applied to a pharmacokinetics and tissue distribution study. The absolute bioavailability (F) of eupatilin was estimated to be 2.7%. ...Taken together, eupatilin showed poor absorption, extensive metabolism into E-7-G and a wide tissue distribution, especially in the intestine. ...
The validated method was then successfully applied to a pharmacokinetics and tissue distribution study. The absolute bioavaila …
Enantioselective Tissue Distribution of Ketorolac and its Enantiomers in Rats.
Dubey SK, et al. Drug Res (Stuttg) 2015. PMID 25350079
The difference in tissue distribution of Ketorolac and its enantiomers were investigated in wistar rats. Separate high performance liquid chromatographic method was developed and validated for determination of Ketorolac and its enantiomers. ...Ketorolac enantiomers exhibit difference in their disposition in Wistar rats. In kidney, there was a significant difference in pharmacokinetic parameters. ...
The difference in tissue distribution of Ketorolac and its enantiomers were investigated in wistar rats. Separate high perform …
Pharmacokinetics, tissue distribution, and excretion of nomegestrol acetate in female rats.
Huang Q, et al. Eur J Drug Metab Pharmacokinet 2015. PMID 25168884
The aim of this study was to evaluate the pharmacokinetics, tissue distribution, and excretion of NOMAC in female rats. Sprague-Dawley female rats were orally administered a single dose of NOMAC (10, 20 or 40 mg/kg) and drug plasma concentrations at different times were determined by RP-HPLC. Tissue distribution at 1, 2, and 4 h and excretion of NOMAC into bile, urine, and feces after dosing were investigated. The results showed that NOMAC was rapidly absorbed after oral administration, with [Formula: see text] of 1-2 h. ...
The aim of this study was to evaluate the pharmacokinetics, tissue distribution, and excretion of NOMAC in female rats. Spragu …
Pharmacokinetics of Exosomes-An Important Factor for Elucidating the Biological Roles of Exosomes and for the Development of Exosome-Based Therapeutics
Morishita M, et al. J Pharm Sci 2017 - Review. PMID 28283433
Moreover, exosomes are expected to be used in therapeutic treatments, such as tissue regeneration therapy and antitumor immunotherapy, because exosomes are effective delivery vehicles for proteins, nucleic acids, and other bioactive compounds. ...The pharmacokinetics of exogenously administered exosomes is discussed based on the tissue distribution, types of cells taking up exosomes, and key molecules in the pharmacokinetics of exosomes. ...
Moreover, exosomes are expected to be used in therapeutic treatments, such as tissue regeneration therapy and antitumor immunotherapy …
Determination of tranilast in bio-samples by LC-MS/MS: Application to a pharmacokinetic and brain tissue distribution study in rats.
Yang W, et al. J Pharm Biomed Anal 2018. PMID 28774678
As a potent drug used to improve the neurodegenerative conditions, there is few information about the brain tissue distribution of tranilast by now. ...The obtained data also showed that tranilast could be quickly distributed and eliminated in brain tissue....
As a potent drug used to improve the neurodegenerative conditions, there is few information about the brain tissue distribution
Physiologically-based modeling of monoclonal antibody pharmacokinetics in drug discovery and development.
Glassman PM and Balthasar JP. Drug Metab Pharmacokinet 2019 - Review. PMID 30522890 Free PMC article.
Additionally, we discuss current and potential future applications of PBPK in the drug discovery and development timeline for mAbs, spanning from identification of potential target molecules to prediction of potential drug-drug interactions. Finally, we conclude with a discussion of currently available PBPK models for mAbs that could be implemented in the drug development process....
Additionally, we discuss current and potential future applications of PBPK in the drug discovery and development timeline for …
β-Carotene in the human body: metabolic bioactivation pathways - from digestion to tissue distribution and excretion.
Bohn T, et al. Proc Nutr Soc 2019 - Review. PMID 30747092
β-Carotene intake and tissue/blood concentrations have been associated with reduced incidence of several chronic diseases. Further bioactive carotenoid-metabolites can modulate the expression of specific genes mainly via the nuclear hormone receptors: retinoic acid receptor- and retinoid X receptor-mediated signalling. ...
β-Carotene intake and tissue/blood concentrations have been associated with reduced incidence of several chronic diseases. Fur …
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