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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 4
1947 4
1950 3
1951 4
1952 12
1953 21
1954 17
1955 42
1956 77
1957 185
1958 247
1959 289
1960 260
1961 292
1962 259
1963 245
1964 243
1965 201
1966 240
1967 256
1968 337
1969 366
1970 325
1971 364
1972 312
1973 383
1974 330
1975 231
1976 216
1977 206
1978 187
1979 173
1980 162
1981 162
1982 154
1983 121
1984 102
1985 122
1986 101
1987 118
1988 120
1989 161
1990 145
1991 125
1992 105
1993 121
1994 117
1995 157
1996 141
1997 120
1998 138
1999 136
2000 147
2001 182
2002 181
2003 169
2004 184
2005 214
2006 212
2007 204
2008 207
2009 197
2010 221
2011 257
2012 215
2013 230
2014 264
2015 238
2016 263
2017 235
2018 237
2019 106
2020 2
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Search Results

12,685 results
Results by year
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Page 1
Branched-chain amino acid metabolism in cancer
Ananieva EA and Wilkinson AC. Curr Opin Clin Nutr Metab Care 2018 - Review. PMID 29211698 Free PMC article.
Autoimmune hepatitis
Mieli-Vergani G, et al. Nat Rev Dis Primers 2018 - Review. PMID 29644994
The diagnosis of AIH relies on increased serum transaminase and immunoglobulin G levels, presence of autoantibodies and interface hepatitis on liver histology. ...
The diagnosis of AIH relies on increased serum transaminase and immunoglobulin G levels, presence of autoantibodies and interface hep …
Glutamine-utilizing transaminases are a metabolic vulnerability of TAZ/YAP-activated cancer cells.
Yang CS, et al. EMBO Rep 2018. PMID 29661856 Free PMC article.
Analysis of enzymes that mediate the conversion of glutamate to AKG shows that TAZ/YAP induce glutamic-oxaloacetic transaminase (GOT1) and phosphoserine aminotransferase (PSAT1) expression and that TAZ/YAP activity positively correlates with transaminase expression in breast cancer patients. Notably, we find that the transaminase inhibitor aminooxyacetate (AOA) represses cell growth in a TAZ/YAP-dependent manner, identifying transamination as a potential vulnerable metabolic requirement for TAZ/YAP-driven breast cancer....
Analysis of enzymes that mediate the conversion of glutamate to AKG shows that TAZ/YAP induce glutamic-oxaloacetic transaminase (GOT1 …
Primary Hyperoxaluria
Jiang D and Geng H. N Engl J Med 2017. PMID 28402768 Free article.
Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.
McBrayer SK, et al. Cell 2018. PMID 30220459 Free PMC article.
Although prior work on (R)-2HG targets focused on 2OG-dependent dioxygenases, we found that (R)-2HG potently inhibits the 2OG-dependent transaminases BCAT1 and BCAT2, likely as a bystander effect, thereby decreasing glutamate levels and increasing dependence on glutaminase for the biosynthesis of glutamate and one of its products, glutathione. ...
Although prior work on (R)-2HG targets focused on 2OG-dependent dioxygenases, we found that (R)-2HG potently inhibits the 2OG-dependent t
Transaminases for chiral amine synthesis.
Gomm A and O'Reilly E. Curr Opin Chem Biol 2018 - Review. PMID 29278779
Amine transaminases are important biocatalysts for the synthesis of chiral primary amines. Unlike many enzymes that have been employed for the synthesis of optically active amines, amine transaminases are capable of asymmetric synthesis and do not rely on costly cofactors that must be regenerated in situ. ...Amine transaminases are also being applied in an increasing range of (chemo)enzymatic cascades and immobilized for applications in flow....
Amine transaminases are important biocatalysts for the synthesis of chiral primary amines. Unlike many enzymes that have been employe …
Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism
Xu T, et al. Nature 2017. PMID 28783731 Free PMC article.
Here, through the discovery and mechanistic characterization of a small molecule, (aminooxy)acetic acid, that reprograms the differentiation of T helper 17 (T(H)17) cells towards induced regulatory T (iT(reg)) cells, we show that increased transamination, mainly catalysed by GOT1, leads to increased levels of 2-hydroxyglutarate in differentiating T(H)17 cells. ...
Here, through the discovery and mechanistic characterization of a small molecule, (aminooxy)acetic acid, that reprograms the differentiation …
12,685 results
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