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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 5
1991 17
1992 25
1993 18
1994 26
1995 25
1996 25
1997 32
1998 34
1999 44
2000 40
2001 40
2002 36
2003 48
2004 28
2005 31
2006 33
2007 34
2008 25
2009 27
2010 20
2011 27
2012 17
2013 16
2014 19
2015 16
2016 11
2017 11
2018 13
2019 9
2020 0
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714 results
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Page 1
Drug rechallenge following drug-induced liver injury.
Hunt CM, et al. Hepatology 2017 - Review. PMID 28295448
Upon withdrawing the suspect drug, ALT generally decrease by 50% or more. With drug readministration, a positive rechallenge has recently been defined by an ALT level of 3-5× ULN or greater. ...Drug rechallenge following drug-induced liver injury is associated with up to 13% mortality in prospective series of all prescribed drugs. ...
Upon withdrawing the suspect drug, ALT generally decrease by 50% or more. With drug readministration, a positive rechallenge h …
Fragment-based approaches to TB drugs
Marchetti C, et al. Parasitology 2018 - Review. PMID 27804891
The rise of antibiotic resistance in Mycobacterium tuberculosis (Mtb) urgently demands the development of new drug leads to tackle resistant strains. ...
The rise of antibiotic resistance in Mycobacterium tuberculosis (Mtb) urgently demands the development of new drug leads to tackle re …
Safety and Tolerability of Moxifloxacin in Children
Dixit A, et al. J Pediatric Infect Dis Soc 2018 - Clinical Trial. PMID 29939314
AEs attributed to moxifloxacin included corrected QT interval (QTc) prolongation (18 [6%] courses), transaminase level elevation (7 [2.3%] courses), and increased bilirubin level (3 [1%] courses). ...The drug might be used safely in most children with monitoring, including evaluation for QTc prolongation, and guidance from ID specialists....
AEs attributed to moxifloxacin included corrected QT interval (QTc) prolongation (18 [6%] courses), transaminase level elevation (7 [ …
Duvelisib, an oral dual PI3K-δ,γ inhibitor, shows clinical and pharmacodynamic activity in chronic lymphocytic leukemia and small lymphocytic lymphoma in a phase 1 study
O'Brien S, et al. Am J Hematol 2018 - Clinical Trial. PMID 30094870 Free article.
Diarrhea was the most common nonhematologic AE (TN 78%, RR 47%); transaminase elevations the most frequent lab-abnormality AE (TN 33.3%, RR 30.9%); and neutropenia the most common ≥grade 3 AE (RR 44%, TN 33%). ...
Diarrhea was the most common nonhematologic AE (TN 78%, RR 47%); transaminase elevations the most frequent lab-abnormality AE (TN 33. …
Duvelisib, an oral dual PI3K-δ, γ inhibitor, shows clinical activity in indolent non-Hodgkin lymphoma in a phase 1 study
Flinn IW, et al. Am J Hematol 2018 - Clinical Trial. PMID 30033575 Free PMC article.
Two dose-limiting toxicities (DLTs), Grade 3 transaminase elevations and Grade 3 rash, occurred at 100 mg BID, and the MTD was determined to be 75 mg BID. ...
Two dose-limiting toxicities (DLTs), Grade 3 transaminase elevations and Grade 3 rash, occurred at 100 mg BID, and the MTD was determ …
A possible biomarker of neurocytolysis in infantile gangliosidoses: aspartate transaminase.
Kılıç M, et al. Metab Brain Dis 2019. PMID 30712135
We aimed to investigate clinical, biochemical and molecular genetic spectrum of Turkish patients with infantile gangliosidoses and examined the potential role of serum aspartate transaminase levels as a biomarker. ...We retrospectively reviewed serum aspartate transaminase levels of patients with other biochemical parameters. Serum aspartate transaminase level was elevated in all GM1 and GM2 gangliosidosis patients in whom the test was performed, along with normal alanine transaminase. ...
We aimed to investigate clinical, biochemical and molecular genetic spectrum of Turkish patients with infantile gangliosidoses and examined …
Effect of trans-chalcone on hepatic IL-8 through the regulation of miR-451 in male rats
Karimi-Sales E, et al. Endocr Regul 2018. PMID 29453920
OBJECTIVE: Trans-chalcone is a chalcone with hepatoprotective and anti-inflammatory effects. However, the mechanism of these positive effects, especially on miR-451 as an inflammatory regulator, is poorly understood. ...
OBJECTIVE: Trans-chalcone is a chalcone with hepatoprotective and anti-inflammatory effects. However, the mechanism of these positive …
The Improvement of the Hepatic Histological Findings in a Patient with Non-alcoholic Steatohepatitis with Type 2 Diabetes after the Administration of the Sodium-glucose Cotransporter 2 Inhibitor Ipragliflozin
Takeda A, et al. Intern Med 2017. PMID 28924123 Free PMC article.
The SGLT2 inhibitor ipragliflozin may be useful as a specific therapeutic drug for NASH....
The SGLT2 inhibitor ipragliflozin may be useful as a specific therapeutic drug for NASH....
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