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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 2
1954 1
1955 3
1956 3
1959 2
1960 3
1961 3
1962 3
1963 4
1964 4
1965 1
1966 1
1967 5
1968 1
1969 3
1970 8
1971 24
1972 281
1973 542
1974 817
1975 743
1976 829
1977 739
1978 802
1979 914
1980 867
1981 1061
1982 1259
1983 1322
1984 1687
1985 1939
1986 2220
1987 2730
1988 3128
1989 3575
1990 3990
1991 4363
1992 4467
1993 4495
1994 4669
1995 4819
1996 5464
1997 5970
1998 5574
1999 5196
2000 5432
2001 5716
2002 5634
2003 5871
2004 5988
2005 6250
2006 6215
2007 6359
2008 6113
2009 4995
2010 5005
2011 6512
2012 8839
2013 9885
2014 9418
2015 9380
2016 9606
2017 9705
2018 9551
2019 5076
2020 90
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202,407 results
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Page 1
Activity-Regulated Transcription: Bridging the Gap between Neural Activity and Behavior.
Yap EL and Greenberg ME. Neuron 2018 - Review. PMID 30359600 Free PMC article.
Gene transcription is the process by which the genetic codes of organisms are read and interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As cells function in their respective niches, transcription further allows mature cells to interact dynamically with their external environment while reliably retaining fundamental information about past experiences. ...
Gene transcription is the process by which the genetic codes of organisms are read and interpreted as a set of instructions fo …
Emerging Principles of Gene Expression Programs and Their Regulation
Pope SD and Medzhitov R. Mol Cell 2018 - Review. PMID 30075140 Free article.
Transcriptional responses to external signals can consist of many hundreds of genes that can be parsed into different categories based on kinetics of induction, cell-type and signal specificity, and duration of the response. Here we discuss the structure of transcription programs and suggest a basic framework to categorize gene expression programs based on characteristics related to their control mechanisms. ...
Transcriptional responses to external signals can consist of many hundreds of genes that can be parsed into different categories base
Genetic evidence for a role of the SREBP transcription system and lipid biosynthesis in schizophrenia and antipsychotic treatment.
Steen VM, et al. Eur Neuropsychopharmacol 2017 - Review. PMID 27492885
The biosynthesis of fatty acids and cholesterol is regulated by the sterol regulatory element binding protein (SREBP) transcription factors SREBP1 and SREBP2, which are encoded by the SREBF1 and SREBF2 genes on chromosome 17p11.2 and 22q13.2, respectively. Here we review the evidence for the involvement of SREBF1 and SREBF2 as genetic risk factors in schizophrenia and discuss the role of myelination and SREBP-mediated lipid biosynthesis in the etiology, pathophysiology and drug treatment of schizophrenia....
The biosynthesis of fatty acids and cholesterol is regulated by the sterol regulatory element binding protein (SREBP) transcription f …
The Cellular Response to Transcription-Blocking DNA Damage.
Gregersen LH and Svejstrup JQ. Trends Biochem Sci 2018 - Review. PMID 29699641 Free PMC article.
In response to transcription-blocking DNA lesions such as those generated by UV irradiation, cells activate a multipronged DNA damage response. This response encompasses repair of the lesions that stall RNA polymerase (RNAP) but also a poorly understood, genome-wide shutdown of transcription, even of genes that are not damaged. ...
In response to transcription-blocking DNA lesions such as those generated by UV irradiation, cells activate a multipronged DNA damage …
Radiogenomics
Story MD and Durante M. Med Phys 2018 - Review. PMID 30421807
From there it covers transcriptome (protein coding RNA transcripts) analysis, which is where the greatest understanding of the molecular signaling responsible for the radioresponse of tumors and normal tissues is known. Non-protein coding RNA transcripts (miRNA, lncRNA), transcribed from what was once thought of as junk DNA, are now known to be negative regulators of the transcription of mRNA by multiple mechanisms. miRNA can act as tumor suppressors or oncogenes regulating a diverse range of cellular processes that drive radioresponse and biosignatures that predict outcome after radiotherapy are described. ...
From there it covers transcriptome (protein coding RNA transcripts) analysis, which is where the greatest understanding of the …
Intrinsic Dynamics of a Human Gene Reveal the Basis of Expression Heterogeneity
Rodriguez J, et al. Cell 2019. PMID 30554876 Free PMC article.
Transcriptional regulation in metazoans occurs through long-range genomic contacts between enhancers and promoters, and most genes are transcribed in episodic "bursts" of RNA synthesis. ...We derive a mathematical model of regulation that relates transcription, chromosome structure, and the cell's ability to sense changes in estrogen and predicts that hypervariability is largely dynamic and does not reflect a stable biological state....
Transcriptional regulation in metazoans occurs through long-range genomic contacts between enhancers and promoters, and most genes ar
Single-cell transcriptional profiling: a window into embryonic cell-type specification.
Pijuan-Sala B, et al. Nat Rev Mol Cell Biol 2018 - Review. PMID 29666443
In this Review, we first discuss recent advances in single-cell transcriptomics and imaging and provide a brief outline of current bioinformatics methods available to analyse the resulting data. ...
In this Review, we first discuss recent advances in single-cell transcriptomics and imaging and provide a brief outline of current bi …
Mechanism for the Regulated Control of Bacterial Transcription Termination by a Universal Adaptor Protein.
Lawson MR, et al. Mol Cell 2018. PMID 30122535 Free PMC article.
NusG/Spt5 proteins are the only transcription factors utilized by all cellular organisms. In enterobacteria, NusG antagonizes the transcription termination activity of Rho, a hexameric helicase, during the synthesis of ribosomal and actively translated mRNAs. ...This study demonstrates how a universally conserved transcription factor acts to modulate the activity of a ring-shaped ATPase motor and establishes how the innate sequence bias of a termination factor can be modulated to silence pervasive, aberrant transcription....
NusG/Spt5 proteins are the only transcription factors utilized by all cellular organisms. In enterobacteria, NusG antagonizes the …
GRO-seq, A Tool for Identification of Transcripts Regulating Gene Expression.
Lopes R, et al. Methods Mol Biol 2017. PMID 28349421
High-throughput transcriptomics became possible with the development of microarray technology, but its widespread application only occurred after the emergence of massive parallel sequencing. ...However, RNA-seq measures the steady-state level of a given RNA, which is the equilibrium between transcription, processing, and degradation. ...
High-throughput transcriptomics became possible with the development of microarray technology, but its widespread application only oc …
Transcription-mediated replication hindrance: a major driver of genome instability.
Gómez-González B and Aguilera A. Genes Dev 2019 - Review. PMID 31123061 Free PMC article.
Experimental evidence reveals that an engaged transcription machinery at the DNA can either enhance such obstacles or be an obstacle itself. ...Understanding the causes behind transcription-replication conflicts as well as how the cell resolves them to sustain genome integrity is the aim of this review....
Experimental evidence reveals that an engaged transcription machinery at the DNA can either enhance such obstacles or be an obstacle …
202,407 results
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