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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1975 1
1978 22
1979 26
1980 43
1981 64
1982 57
1983 69
1984 98
1985 134
1986 156
1987 203
1988 326
1989 553
1990 873
1991 1254
1992 1374
1993 1768
1994 2118
1995 2779
1996 3297
1997 3922
1998 4615
1999 5436
2000 6293
2001 6549
2002 6993
2003 7630
2004 8305
2005 8813
2006 10615
2007 11125
2008 11892
2009 12671
2010 14112
2011 15954
2012 16955
2013 17945
2014 17426
2015 17362
2016 17168
2017 17342
2018 16601
2019 7855
2020 159
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251,600 results
Results by year
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Page 1
Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis
Zammit PS. Semin Cell Dev Biol 2017 - Review. PMID 29127046
Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal muscle lineage and control of myogenic differentiation during development. ...
Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in under …
Nrf2-Keap1 signaling in oxidative and reductive stress
Bellezza I, et al. Biochim Biophys Acta Mol Cell Res 2018 - Review. PMID 29499228 Free article.
The heterodimers recognize the AREs, that are enhancer sequences present in the regulatory regions of Nrf2 target genes, essential for the recruitment of key factors for transcription. ...
The heterodimers recognize the AREs, that are enhancer sequences present in the regulatory regions of Nrf2 target genes, essential for the r …
Genetic compensation of RUNX family transcription factors in leukemia.
Kamikubo Y. Cancer Sci 2018 - Review. PMID 29883054 Free PMC article.
Runt (Runt domain)-related transcription factor 1 (RUNX1) is a transcription factor belonging to the core-binding factor (CBF) family. ...In this review, we describe the significance and paradoxical requirement of RUNX1 tumor suppressor in hematological malignancies based on recent findings such as "Genetic compensation of RUNX family transcription factors in leukemia," "RUNX1 inhibition-induced inhibitory effects on leukemia cells through p53 activation" and our novel promising theory "Cluster regulation of RUNX (CROX)" through the RUNX gene switch method using pyrrole-imidazole polyamides as a new technique that could contribute to the next generation of leukemia treatment strategies....
Runt (Runt domain)-related transcription factor 1 (RUNX1) is a transcription factor belonging to the core-binding factor (CBF) …
PAX3-FOXO1: Zooming in on an "undruggable" target
Wachtel M and Schäfer BW. Semin Cancer Biol 2018 - Review. PMID 29146205 Free article.
Driver oncogenes are prime targets for therapy in tumors many of which, including leukemias and sarcomas, express recurrent fusion transcription factors. ...One can envision strategies at different molecular levels including upstream modifiers and activators, epigenetic and transcriptional co-regulators, and downstream effector targets. ...
Driver oncogenes are prime targets for therapy in tumors many of which, including leukemias and sarcomas, express recurrent fusion transc
The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis.
Li Y, et al. J Allergy Clin Immunol 2018. PMID 29277702 Free PMC article.
OBJECTIVE: We sought to investigate the in vivo regulation of IgE/mast cell-mediated anaphylaxis by the transcription factors GATA2 and microphthalmia-associated transcription factor (MITF) and the mechanisms by which GATA2 and MITF regulate Hdc gene expression in mouse and human mast cells. ...MITF bound to an enhancer located 8.8 kb upstream of the transcription start site of the Hdc gene and directed enhancer activity. ...
OBJECTIVE: We sought to investigate the in vivo regulation of IgE/mast cell-mediated anaphylaxis by the transcription factors GATA2 a …
Role of Forkhead Box Class O proteins in cancer progression and metastasis
Kim CG, et al. Semin Cancer Biol 2018 - Review. PMID 28774834 Free PMC article.
It is now widely accepted that several gene alterations including transcription factors are critically involved in cancer progression and metastasis. Forkhead Box Class O proteins (FoxOs) including FoxO1/FKHR, FoxO3/FKHRL1, FoxO4/AFX and FoxO6 transcription factors are known to play key roles in proliferation, apoptosis, metastasis, cell metabolism, aging and cancer biology through their phosphorylation, ubiquitination, acetylation and methylation. ...
It is now widely accepted that several gene alterations including transcription factors are critically involved in cancer progression …
The interplay of chromatin and transcription factors during cell fate transitions in development and reprogramming.
Peñalosa-Ruiz G, et al. Biochim Biophys Acta Gene Regul Mech 2019 - Review. PMID 31356991 Free article.
In addition, rewiring the transcriptional network back to pluripotency involves overcoming molecular barriers that protect or stabilize the somatic identity, whereas extrinsic and intrinsic cues will drive differentiation in an energetically favorable landscape in the embryo. This review focuses on how cell fate transitions in reprogramming and development are differentially governed by interactions between transcription factors and chromatin. ...
In addition, rewiring the transcriptional network back to pluripotency involves overcoming molecular barriers that protect or stabili …
Thrombocytopenia in leukemia: Pathogenesis and prognosis
Shahrabi S, et al. Histol Histopathol 2018 - Review. PMID 29460950
It can be stated that although translocations have been considered responsible for this complication in many studies, other factors such as bone marrow failure, genes polymorphism, a mutation in some transcription factors, and the adverse effects of treatment could be associated with pathogenesis and poor prognosis of thrombocytopenia in leukemias. ...
It can be stated that although translocations have been considered responsible for this complication in many studies, other factors such as …
Expression of transcription factors during area pellucida formation in intrauterine chicken embryos.
Han JY, et al. Int J Dev Biol 2018. PMID 29877574 Free article.
We traced the early expression of the transcription factors NANOG, POUV and EOMES at Eyal-Giladi and Kochav (EGK) stages VI through X using in situ hybridization. ...Our results on the spatiotemporal expression of transcription factors contribute to a greater understanding of the dynamic process of intrauterine development in chickens....
We traced the early expression of the transcription factors NANOG, POUV and EOMES at Eyal-Giladi and Kochav (EGK) stages VI through X …
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