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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2003 5
2004 2
2005 1
2006 2
2007 1
2008 3
2009 9
2010 60
2011 1115
2012 3227
2013 4293
2014 4758
2015 5020
2016 5461
2017 5987
2018 6266
2019 3749
2020 92
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35,548 results
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Page 1
Simultaneous epitope and transcriptome measurement in single cells.
Stoeckius M, et al. Nat Methods 2017. PMID 28759029 Free PMC article.
Here, we describe cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq), a method in which oligonucleotide-labeled antibodies are used to integrate cellular protein and transcriptome measurements into an efficient, single-cell readout. ...
Here, we describe cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq), a method in which oligonucleotide-labele …
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.
Xue J, et al. Immunity 2014. PMID 24530056 Free PMC article.
Macrophage activation is associated with profound transcriptional reprogramming. Although much progress has been made in the understanding of macrophage activation, polarization, and function, the transcriptional programs regulating these processes remain poorly characterized. ...Network analyses identified central transcriptional regulators associated with all macrophage activation complemented by regulators related to stimulus-specific programs. ...
Macrophage activation is associated with profound transcriptional reprogramming. Although much progress has been made in the understa …
Identifying cell populations with scRNASeq
Andrews TS and Hemberg M. Mol Aspects Med 2018 - Review. PMID 28712804 Free article.
Single-cell RNASeq (scRNASeq) has emerged as a powerful method for quantifying the transcriptome of individual cells. However, the data from scRNASeq experiments is often both noisy and high dimensional, making the computational analysis non-trivial. ...
Single-cell RNASeq (scRNASeq) has emerged as a powerful method for quantifying the transcriptome of individual cells. However, the da …
Quantifying tumor-infiltrating immune cells from transcriptomics data.
Finotello F and Trajanoski Z. Cancer Immunol Immunother 2018 - Review. PMID 29541787 Free PMC article.
In this review, we describe state-of-the-art computational methods for the quantification of immune cells from transcriptomics data and discuss the open challenges that must be addressed to accurately quantify immune infiltrates from RNA sequencing data of human bulk tumors....
In this review, we describe state-of-the-art computational methods for the quantification of immune cells from transcriptomics data a …
Barrier Properties and Transcriptome Expression in Human iPSC-Derived Models of the Blood-Brain Barrier.
Delsing L, et al. Stem Cells 2018. PMID 30171748 Free article.
Whole genome expression profiling revealed transcriptional changes that occur in coculture, including upregulation of tight junction proteins, such as claudins and neurotransmitter transporters. ...Our data suggest that coculture of iPSC-derived endothelial cells promotes barrier formation on a functional and transcriptional level. ...
Whole genome expression profiling revealed transcriptional changes that occur in coculture, including upregulation of tight junction …
The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease
Schiller HB, et al. Am J Respir Cell Mol Biol 2019 - Review. PMID 30995076 Free PMC article.
Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, aging, or disease. ...
Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to …
Transcriptome-wide discovery of coding and noncoding RNA-binding proteins.
Huang R, et al. Proc Natl Acad Sci U S A 2018. PMID 29636419 Free PMC article.
Transcriptome-wide identification of RNA-binding proteins (RBPs) is a prerequisite for understanding the posttranscriptional gene regulation networks. ...
Transcriptome-wide identification of RNA-binding proteins (RBPs) is a prerequisite for understanding the posttranscriptional gene reg
RUNX1-ETO Leukemia
Lin S, et al. Adv Exp Med Biol 2017 - Review. PMID 28299657
Proteomic surveies have shown that AML-ETO forms a stable complex with several transcription factors, including E proteins. Genome-wide transcriptome and ChIP-seq analyses have revealed the genes directly regulated by AML1-ETO, such as CEBPA. ...
Proteomic surveies have shown that AML-ETO forms a stable complex with several transcription factors, including E proteins. Genome-wi …
High-throughput single-cell transcriptomics on organoids.
Brazovskaja A, et al. Curr Opin Biotechnol 2019 - Review. PMID 30504008
Single-cell transcriptomics has been used to quantitate the similarity of organoid cells to primary tissue counterparts in the brain, intestine, liver, and kidney, as well as identify cell-specific responses to environmental variables and disease conditions. ...
Single-cell transcriptomics has been used to quantitate the similarity of organoid cells to primary tissue counterparts in the brain, …
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