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Year Number of Results
2000 1
2004 2
2005 5
2006 56
2007 124
2008 121
2009 117
2010 154
2011 146
2012 136
2013 147
2014 137
2015 151
2016 133
2017 152
2018 139
2019 46
2020 1
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1,499 results
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Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells.
Smith LC, et al. Respir Res 2018. PMID 30165855 Free PMC article.
Reports using cell lines have investigated molecular interactions between transforming growth factor beta1 (TGF-β1) and estrogen receptor (ESR) pathways in breast, prostate, and skin cells, but no such interactions have been described in human lung cells. ...
Reports using cell lines have investigated molecular interactions between transforming growth factor beta1 (TGF- …
Brain Transforming Growth Factor-β Resists Hypertension Via Regulating Microglial Activation.
Li Y, et al. Stroke 2017. PMID 28698257 Free PMC article.
Antibody, pharmacological chemical, and recombinant cytokine were administered to the brain through intracerebroventricular infusion. ...RESULTS: Transforming growth factor-β (TGF-β) is constitutively expressed in the brains of normotensive mice. Removal of TGF-β or blocking its signaling before hypertension induction accelerated hypertension progression, whereas supplementation of TGF-β1 substantially suppressed neuroinflammation, kidney norepinephrine level, and blood pressure. ...
Antibody, pharmacological chemical, and recombinant cytokine were administered to the brain through intracerebroventricular infusion. …
Role of the Transforming Growth Factor-β in regulating hepatocellular carcinoma oxidative metabolism.
Soukupova J, et al. Sci Rep 2017. PMID 28970582 Free PMC article.
Transforming Growth Factor beta (TGF-β) induces tumor cell migration and invasion. However, its role in inducing metabolic reprogramming is poorly understood. ...
Transforming Growth Factor beta (TGF-β) induces tumor cell migration and invasion. However, its role in inducing metabo
Hypoxia and transforming growth factor-beta1 pathway activation promote Chinese Hamster Ovary cell aggregation.
Qian Y, et al. Biotechnol Bioeng 2018. PMID 29251349
Significantly, hypoxia was identified to be a cause for promoting CHO cell aggregation, and transforming growth factor beta1 (TGFβ1) pathway activation served as an intermediate step mediating this biological cascade. ...
Significantly, hypoxia was identified to be a cause for promoting CHO cell aggregation, and transforming growth factor
Transforming growth factor-β1 protects against intestinal epithelial barrier dysfunction caused by hypoxia-reoxygenation.
Howe KL, et al. Shock 2015. PMID 25608140
Transforming growth factor-β1 pretreatment ameliorated HR-induced epithelial barrier dysfunction in T84 (at 1 - 3 h) and Caco-2 (1 h) monolayers. ...Transforming growth factor-β1 preserves loss of epithelial barrier integrity caused by the stress of HR via a mechanism that may involve the upregulation of HO-1 transcription. ...
Transforming growth factor-β1 pretreatment ameliorated HR-induced epithelial barrier dysfunction in T84 (at 1 - 3 h) an
Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1.
Jin J, et al. Respir Res 2019. PMID 31185973 Free PMC article.
BACKGROUND: Pirfenidone, an antifibrotic agent used for the treatment of idiopathic pulmonary fibrosis (IPF), functions by inhibiting myofibroblast differentiation, which is involved in transforming growth factor (TGF)-β1-induced IPF pathogenesis. ...The ability of two new pharmacological targets of pirfenidone, collagen triple helix repeat containing protein 1(CTHRC1) and four-and-a-half LIM domain protein 2 (FHL2), to mediate contraction of collagen gels and migration toward fibronectin were assessed in vitro. ...
BACKGROUND: Pirfenidone, an antifibrotic agent used for the treatment of idiopathic pulmonary fibrosis (IPF), functions by inhibiting myofib …
Transforming growth factor-beta1 regulates the fate of cultured spinal cord-derived neural progenitor cells.
Park SM, et al. Cell Prolif 2008. PMID 18336470
OBJECTIVES: We have evaluated the physiological roles of transforming growth factor-beta1 (TGF-beta1) on differentiation, migration, proliferation and anti-apoptosis characteristics of cultured spinal cord-derived neural progenitor cells. ...RESULTS AND CONCLUSIONS: Transforming growth factor-beta1-mediated cell population growth was activated after treatment and was also effectively blocked by an ALK41517-synthetic inhibitor (4-(5-benzo(1,3) dioxol-5-yl-4-pyridine-2-yl-1H-imidazole-2-yl) benzamide (SB431542) and ALK siRNA, thereby indicating the involvement of SMAD2 in the TGF-beta1-mediated growth and migration of these neural progenitors cells (NPC). ...
OBJECTIVES: We have evaluated the physiological roles of transforming growth factor-beta1 (TGF-beta1) on …
Role of transforming growth factor-beta1 in cyclosporine-induced epithelial-to-mesenchymal transition in gingival epithelium.
Fu MM, et al. J Periodontol 2015. PMID 25272978
The aims of the present study are to confirm the notion that EMT occurs in human gingival epithelial (hGE) cells after CsA treatment and to investigate the role of transforming growth factor beta1 (TGF-β1) on this CsA-induced EMT. ...
The aims of the present study are to confirm the notion that EMT occurs in human gingival epithelial (hGE) cells after CsA treatment and to …
Repressive role of stabilized hypoxia inducible factor 1α expression on transforming growth factor β-induced extracellular matrix production in lung cancer cells.
Ando A, et al. Cancer Sci 2019. PMID 31004547 Free PMC article.
Activation of transforming growth factor β (TGF-β) combined with persistent hypoxia often affects the tumor microenvironment. ...Stabilized HIF-1α protein expression inhibited the TGF-β-stimulated appearance of EMT phenotypes across cell types and species, independent of de novo vascular endothelial growth factor A (VEGFA) expression. ...
Activation of transforming growth factor β (TGF-β) combined with persistent hypoxia often affects the tumor microenviro …
Effect of exogenous transforming growth factor β1 (TGF-β1) on early bovine embryo development.
Barrera AD, et al. Zygote 2018. PMID 29880072
SummaryDuring preimplantation development, embryos are exposed and have the capacity to respond to different growth factors present in the maternal environment. Among these factors, transforming growth factor β1 (TGF-β1) is a well known modulator of embryonic growth and development. However, its action during the first stages of development, when the embryo transits through the oviduct, has not been yet elucidated. ...
SummaryDuring preimplantation development, embryos are exposed and have the capacity to respond to different growth factors present i …
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