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Management of delayed hemolytic transfusion reaction in sickle cell disease: Prevention, diagnosis, treatment.
Pirenne F, et al. Transfus Clin Biol 2017. PMID 28669521
Transfusion remains a key treatment of sickle cell disease complications. However, delayed hemolytic transfusion reaction, the most serious complication of transfusion, may be life-threatening if hyperhemolysis develops. ...Early diagnosis might make it possible to implement specific treatments in some cases, thereby avoiding the need for secondary transfusion. ...
Transfusion remains a key treatment of sickle cell disease complications. However, delayed hemolytic transfusion reaction
Transfusion-associated circulatory overload and transfusion-related acute lung injury.
Semple JW, et al. Blood 2019 - Review. PMID 30808638
Transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI) are syndromes of acute respiratory distress that occur within 6 hours of blood transfusion. ...Collectively, this may result in improved diagnostics and development of therapeutic approaches for these life-threatening transfusion reactions....
Transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI) are syndromes of acute re
Comparing transfusion reaction risks for various plasma products - an analysis of 7 years of ISTARE haemovigilance data.
Saadah NH, et al. Br J Haematol 2018. PMID 29318576
Plasma transfusions may result in transfusion reactions. We used the International Surveillance of Transfusion-Associated Reactions and Events (ISTARE) database, containing yearly reported national annual aggregate data on transfusion reactions from participating countries, to investigate risks of plasma transfusion reactions and compare transfusion reaction risks for different plasma types. We calculated risks for plasma transfusion reactions and compared transfusion reaction risks between plasma types using random effects regression on repeated measures. ...
Plasma transfusions may result in transfusion reactions. We used the International Surveillance of Transfusion-Associat …
The first case of severe acute hemolytic transfusion reaction caused by anti-Sc2.
Lemay AS, et al. Transfusion 2018. PMID 30299537
The transfusion history was reviewed and a monocyte monolayer assay (MMA) was performed. RESULTS: The patient was investigated for a RBC reaction 9 years prior, when she developed symptoms of HTR. ...Finally, the transfusion reaction reported herein occurred when she received by happenstance RBCs from the same donor who was associated with the remote reaction 9 years earlier. ...
The transfusion history was reviewed and a monocyte monolayer assay (MMA) was performed. RESULTS: The patient was investigated for a …
Transfusion-related red blood cell alloantibodies: induction and consequences.
Tormey CA and Hendrickson JE. Blood 2019 - Review. PMID 30808636 Free PMC article.
Blood transfusion is the most common procedure completed during a given hospitalization in the United States. Although often life-saving, transfusions are not risk-free. ...Alloantibodies may be clinically significant in future transfusion scenarios, potentially resulting in acute or delayed hemolytic transfusion reactions or in difficulty locating compatible RBC units for future transfusion. ...
Blood transfusion is the most common procedure completed during a given hospitalization in the United States. Although often life-sav …
How I safely transfuse patients with sickle-cell disease and manage delayed hemolytic transfusion reactions.
Pirenne F and Yazdanbakhsh K. Blood 2018 - Review. PMID 29724898 Free PMC article.
Development of antibodies against the transfused red blood cells (RBCs), resulting in delayed hemolytic transfusion reactions (DHTRs), can be life-threatening and pose unique challenges for this population with regard to treatment strategies and transfusion management protocols. ...Guidelines are needed for early diagnosis of DHTR because treatment may need to include temporarily withholding any new transfusions to avoid further hemolysis. ...
Development of antibodies against the transfused red blood cells (RBCs), resulting in delayed hemolytic transfusion reactions (DHTRs) …
Immuno-hematological findings in Delayed Hemolytic Transfusion Reaction (DHTR).
Thonier V. Transfus Clin Biol 2019 - Review. PMID 30885514
Transfusion is still a key treatment for patients suffering from this condition. As a result, SCD patients are much more exposed to transfusions and their risks than the general population. The most feared situation is delayed hemolytic transfusion reaction (DHTR). In certain situations, defined as hyperhemolysis, autologous red blood cells (RBCs) are also targeted and destroyed. ...
Transfusion is still a key treatment for patients suffering from this condition. As a result, SCD patients are much more exposed to
An acute transfusion reaction.
Webb C, et al. Clin Med (Lond) 2018. PMID 29436447 Free PMC article.
We present the case of a 67-year-old man who suffered an acute anaphylactic reaction during red cell transfusion due to the presence of anti-IgA antibodies. ...This case highlights the need to consider the potential risks of blood component transfusion against the purported benefit....
We present the case of a 67-year-old man who suffered an acute anaphylactic reaction during red cell transfusion due to the pr …
The Liver in Sickle Cell Disease
Theocharidou E and Suddle AR. Clin Liver Dis 2019 - Review. PMID 30947870
Patients with sickle cell disease can develop liver disease as a result of intrahepatic sickling of erythrocytes, viral hepatitis and iron overload secondary to multiple blood transfusions, and gallstone disease as a result of chronic hemolysis. ...Exchange blood transfusions may improve outcomes in the acute liver syndromes. Liver transplantation may be an option for chronic liver disease. ...
Patients with sickle cell disease can develop liver disease as a result of intrahepatic sickling of erythrocytes, viral hepatitis and iron o …
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