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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 3
1947 1
1948 3
1949 1
1950 2
1951 1
1955 1
1957 2
1959 1
1960 5
1961 7
1962 18
1963 26
1964 27
1965 16
1967 3
1969 1
1970 2
1971 5
1972 9
1973 8
1974 170
1975 321
1976 299
1977 298
1978 289
1979 346
1980 276
1981 315
1982 338
1983 380
1984 487
1985 529
1986 627
1987 570
1988 607
1989 567
1990 614
1991 649
1992 774
1993 767
1994 733
1995 800
1996 812
1997 781
1998 830
1999 811
2000 888
2001 883
2002 855
2003 870
2004 806
2005 883
2006 872
2007 973
2008 884
2009 767
2010 826
2011 860
2012 888
2013 828
2014 840
2015 786
2016 716
2017 660
2018 561
2019 303
2020 10
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Search Results

28,637 results
Results by year
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Page 1
A guide to genome engineering with programmable nucleases
Kim H and Kim JS. Nat Rev Genet 2014 - Review. PMID 24690881
Programmable nucleases - including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and RNA-guided engineered nucleases (RGENs) derived from the bacterial clustered regularly interspaced short palindromic repeat (CRISPR)-Cas (CRISPR-associated) system - enable targeted genetic modifications in cultured cells, as well as in whole animals and plants. ...
Programmable nucleases - including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and RNA-guided eng …
The establishment and application of preimplantation genetic haplotyping in embryo diagnosis for reciprocal and Robertsonian translocation carriers.
Zhang S, et al. BMC Med Genomics 2017. PMID 29041973 Free PMC article.
BACKGROUND: Preimplantation genetic diagnosis (PGD) is now widely used to select embryos free of chromosomal copy number variations (CNV) from chromosome balanced translocation carriers. ...METHODS: For this purpose, genome wide preimplantation genetic haplotyping (PGH) analysis was utilized based on single nucleotide polymorphism (SNP) microarray. ...
BACKGROUND: Preimplantation genetic diagnosis (PGD) is now widely used to select embryos free of chromosomal copy number variations ( …
Advances in chromosomal translocations and fusion genes in sarcomas and potential therapeutic applications.
Xiao X, et al. Cancer Treat Rev 2018 - Review. PMID 29247978
Chromosomal translocations and fusion genes are very common in human cancer especially in subtypes of sarcomas, such as rhabdomyosarcoma, Ewing's sarcoma, synovial sarcoma and liposarcoma. ...Recently, many novel chromosomal translocations and gene fusions have been identified in different types of sarcoma through NGS approaches. ...
Chromosomal translocations and fusion genes are very common in human cancer especially in subtypes of sarcomas, such as rhabdomyosarc …
BasePhasing: a highly efficient approach for preimplantation genetic haplotyping in clinical application of balanced translocation carriers.
Zhang S, et al. BMC Med Genomics 2019. PMID 30885195 Free PMC article.
BACKGROUND: Preimplantation genetic testing (PGT) has already been applied in chromosomally balanced translocation carriers to improve the clinical outcome of assisted reproduction. ...CONCLUSIONS: Infinium ASA bead chip based BasePhasing pipeline shows good performance in balanced translocation carrier testing. ...
BACKGROUND: Preimplantation genetic testing (PGT) has already been applied in chromosomally balanced translocation carriers to …
De novo unbalanced translocations have a complex history/aetiology.
Bonaglia MC, et al. Hum Genet 2018 - Clinical Trial. PMID 30276538
Notably, this mechanism also fits with the origin of some simple translocations in which the duplicated region was of paternal origin. ...Our data imply that there is no risk of recurrence in the following pregnancies for any of the de novo unbalanced translocations we discuss here....
Notably, this mechanism also fits with the origin of some simple translocations in which the duplicated region was of paternal origin …
Inhibition of Parp1 by BMN673 Effectively Sensitizes Cells to Radiotherapy by Upsetting the Balance of Repair Pathways Processing DNA Double-Strand Breaks
Soni A, et al. Mol Cancer Ther 2018. PMID 29970481 Free article.
The combined outcome of these effects is an abrogation in the inherent balance of DSB processing culminating in the formation of chromosomal translocations that underpin radiosensitization. ...
The combined outcome of these effects is an abrogation in the inherent balance of DSB processing culminating in the formation of chromosomal …
Twenty years of FISH-based translocation analysis for retrospective ionizing radiation biodosimetry.
Grégoire E, et al. Int J Radiat Biol 2018. PMID 29363380
The persistence of translocations enabled us to corroborate an overexposure 44 years earlier. Interpretation of the observed translocation yield requires the knowledge of the patient's other radiation exposures. ...When the radiation dose is greater than 1 Gy, the translocations in complex exchanges must be considered. Another relevant point is the use of an appropriate background yield of translocations. ...
The persistence of translocations enabled us to corroborate an overexposure 44 years earlier. Interpretation of the observed trans
The t(8;14)(q24.1;q32) and its variant translocations: A study of 34 cases.
Angi M, et al. Hematol Oncol Stem Cell Ther 2017. PMID 28390216 Free article.
RESULTS: There were 34 patients with 8q24 translocations (31, ALL and three myeloma). The t(8;14) was seen in 25 patients, t(8;22) in seven and t(2;8) in two. ...CONCLUSION: The frequency (1.7%) and distribution of these translocations in our series and the association with 1q and 13q abnormalities is similar to the literature. ...
RESULTS: There were 34 patients with 8q24 translocations (31, ALL and three myeloma). The t(8;14) was seen in 25 patients, t(8;22) in …
Chromosome kissing
Cavalli G. Curr Opin Genet Dev 2007 - Review. PMID 17933509
Promoting single-file DNA translocations through nanopores using electro-osmotic flow.
Ermann N, et al. J Chem Phys 2018. PMID 30384733
Double-stranded DNA translocates through sufficiently large nanopores either in a linear single-file fashion or in a folded hairpin conformation when captured somewhere along its length. ...At pH 8 in 1M LiCl or 0.35M KCl, single-file translocations make up more than 90% of the total. We attribute the effect to the onset of electro-osmotic flow from the pore at low ionic strength. ...
Double-stranded DNA translocates through sufficiently large nanopores either in a linear single-file fashion or in a folded hairpin c …
28,637 results
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