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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1949 2
1956 2
1957 2
1958 3
1959 6
1960 4
1961 5
1962 5
1963 4
1964 9
1965 6
1972 3
1973 25
1974 47
1975 44
1976 24
1977 21
1978 18
1979 19
1980 16
1981 5
1982 14
1983 10
1984 12
1985 20
1986 25
1987 16
1988 22
1989 28
1990 30
1991 37
1992 35
1993 47
1994 60
1995 59
1996 64
1997 78
1998 75
1999 70
2000 94
2001 92
2002 97
2003 116
2004 115
2005 131
2006 151
2007 195
2008 181
2009 198
2010 176
2011 182
2012 214
2013 212
2014 225
2015 219
2016 207
2017 214
2018 216
2019 132
2020 1
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3,929 results
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Page 1
Dietary trehalose enhances virulence of epidemic Clostridium difficile.
Collins J, et al. Nature 2018. PMID 29310122 Free PMC article.
RT027 strains contain a single point mutation in the trehalose repressor that increases the sensitivity of this ribotype to trehalose by more than 500-fold. Furthermore, dietary trehalose increases the virulence of a RT027 strain in a mouse model of infection. RT078 strains acquired a cluster of four genes involved in trehalose metabolism, including a PTS permease that is both necessary and sufficient for growth on low concentrations of trehalose. ...
RT027 strains contain a single point mutation in the trehalose repressor that increases the sensitivity of this ribotype to trehal
Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways.
Mizunoe Y, et al. Redox Biol 2018. PMID 29241092 Free PMC article.
In addition, trehalose functions as an antioxidant though its underlying molecular mechanisms remain unclear. In this study, we showed that trehalose not only promoted autophagy, but also increased p62 protein expression, in an autophagy-independent manner. ...Moreover, treatment with trehalose significantly reduced amount of reactive oxygen species. Collectively, these results suggested that trehalose can function as a novel activator of the p62-Keap1/Nrf2 pathway, in addition to inducing autophagy. ...
In addition, trehalose functions as an antioxidant though its underlying molecular mechanisms remain unclear. In this study, we showe …
Trehalose in ophthalmology.
Cejka C, et al. Histol Histopathol 2019 - Review. PMID 30623968
Trehalose, a disaccharide of glucose, is a naturally occurring nontoxic and nonreducing bioactive sugar. Trehalose is synthetized by many organisms when cells are exposed to stressful conditions, including dehydration, heat, oxidation, hypoxia or even anoxia. ...Trehalose enables wound healing by protecting cells, especially cell membranes, from oxidative injury and dessication. When the injured cornea is treated with trehalose, corneal inflammation, scar formation and corneal neovascularization are suppressed. ...
Trehalose, a disaccharide of glucose, is a naturally occurring nontoxic and nonreducing bioactive sugar. Trehalose is syntheti
Autophagy induction by trehalose: Molecular mechanisms and therapeutic impacts.
Hosseinpour-Moghaddam K, et al. J Cell Physiol 2018 - Review. PMID 29663416
Trehalose, also known as mycose, is a natural disaccharide found extensively but not abundantly among several organisms. It is described that trehalose can work as an important autophagy modulator and can be proficiently used in the control several diseases in which autophagy plays an important role. On these bases, we describe here the role of trehalose as an innovative drug in the treatment of neurodegenerative diseases and other illnesses opening a new scenario of intervention in conditions difficult to be treated....
Trehalose, also known as mycose, is a natural disaccharide found extensively but not abundantly among several organisms. It is descri
Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction.
Lee HJ, et al. Cell Death Dis 2018 - Review. PMID 29907758 Free PMC article.
The mechanism underlying the neuroprotective effects of trehalose remains elusive. The prevailing hypothesis is that trehalose protects neurons by inducing autophagy, thereby clearing protein aggregates. ...Furthermore, a recent study with a thorough examination of autophagy flux showed that trehalose interfered with the flux from autophagosome to autolysosome, raising controversy on the direct effects of trehalose on autophagy. ...
The mechanism underlying the neuroprotective effects of trehalose remains elusive. The prevailing hypothesis is that trehalose
Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction.
Sciarretta S, et al. J Am Coll Cardiol 2018. PMID 29724354 Free PMC article.
Trehalose administration to mice overexpressing GFP-tagged LC3 significantly increased the number of GFP-LC3 dots, both in the presence and absence of chloroquine administration. ...To evaluate whether TRE exerted beneficial effects through activation of autophagy, trehalose was administered to beclin 1+/- mice. ...
Trehalose administration to mice overexpressing GFP-tagged LC3 significantly increased the number of GFP-LC3 dots, both in the presen
Trehalose 6-Phosphate Positively Regulates Fatty Acid Synthesis by Stabilizing WRINKLED1.
Zhai Z, et al. Plant Cell 2018. PMID 30249634 Free PMC article.
We tested the hypothesis that trehalose 6-phosphate (T6P), a signal of cellular sucrose status, can regulate fatty acid synthesis by inhibiting SnRK1. ...
We tested the hypothesis that trehalose 6-phosphate (T6P), a signal of cellular sucrose status, can regulate fatty acid synthesis by …
Trehalose in Water Revisited.
Soper AK, et al. J Phys Chem B 2018. PMID 29965765
In the first study, which looks at two concentrations of trehalose-water mole ratios of 1:100 and 1:25, the conclusion is that trehalose hydrogen-bonds to water rather weakly and has a relatively minor impact on the structure of water in solution compared to bulk water. On the other hand, for the other, using a mole ratio of 1:38, the conclusion is that the water structure is rather substantially modified by the presence of trehalose and that the hydrogen bonding between water and trehalose hydroxyl groups is significant. ...
In the first study, which looks at two concentrations of trehalose-water mole ratios of 1:100 and 1:25, the conclusion is that tre
TFEB and trehalose drive the macrophage autophagy-lysosome system to protect against atherosclerosis.
Evans TD, et al. Autophagy 2018. PMID 29394113 Free PMC article.
Further, we characterized the disaccharide trehalose as a novel inducer of TFEB with similar atheroprotective effects. Overall, these findings mechanistically interrogate the importance and therapeutic promise of a functional autophagy-lysosome degradation system in plaque macrophage biology....
Further, we characterized the disaccharide trehalose as a novel inducer of TFEB with similar atheroprotective effects. Overall, these …
Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency.
Lotfi P, et al. Autophagy 2018. PMID 29916295 Free PMC article.
To determine whether inducing macroautophagy/autophagy via small-molecule therapy would be effective for neuropathic LSDs due to enzyme deficiency, we treated a mouse model of mucopolysaccharidosis IIIB (MPS IIIB), a storage disorder caused by deficiency of the enzyme NAGLU (alpha-N-acetylglucosaminidase [Sanfilippo disease IIIB]), with the autophagy-inducing compound trehalose. ...
To determine whether inducing macroautophagy/autophagy via small-molecule therapy would be effective for neuropathic LSDs due to enzyme defi …
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