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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 2
1975 1
1976 1
1977 1
1978 1
1983 1
1985 2
1986 1
1988 1
1989 1
1991 2
1992 3
1993 3
1994 7
1995 3
1996 5
1997 8
1998 5
1999 5
2000 6
2001 12
2002 12
2003 12
2004 11
2005 16
2006 16
2007 20
2008 16
2009 27
2010 22
2011 16
2012 27
2013 19
2014 25
2015 27
2016 29
2017 41
2018 32
2019 21
2020 0
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418 results
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Page 1
Dietary trehalose enhances virulence of epidemic Clostridium difficile.
Collins J, et al. Nature 2018. PMID 29310122 Free PMC article.
RT027 strains contain a single point mutation in the trehalose repressor that increases the sensitivity of this ribotype to trehalose by more than 500-fold. Furthermore, dietary trehalose increases the virulence of a RT027 strain in a mouse model of infection. RT078 strains acquired a cluster of four genes involved in trehalose metabolism, including a PTS permease that is both necessary and sufficient for growth on low concentrations of trehalose. ...
RT027 strains contain a single point mutation in the trehalose repressor that increases the sensitivity of this ribotype to trehal
Trehalose in ophthalmology.
Cejka C, et al. Histol Histopathol 2019 - Review. PMID 30623968
Trehalose, a disaccharide of glucose, is a naturally occurring nontoxic and nonreducing bioactive sugar. Trehalose is synthetized by many organisms when cells are exposed to stressful conditions, including dehydration, heat, oxidation, hypoxia or even anoxia. ...Trehalose enables wound healing by protecting cells, especially cell membranes, from oxidative injury and dessication. When the injured cornea is treated with trehalose, corneal inflammation, scar formation and corneal neovascularization are suppressed. ...
Trehalose, a disaccharide of glucose, is a naturally occurring nontoxic and nonreducing bioactive sugar. Trehalose is syntheti
Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways.
Mizunoe Y, et al. Redox Biol 2018. PMID 29241092 Free PMC article.
In addition, trehalose functions as an antioxidant though its underlying molecular mechanisms remain unclear. In this study, we showed that trehalose not only promoted autophagy, but also increased p62 protein expression, in an autophagy-independent manner. ...Moreover, treatment with trehalose significantly reduced amount of reactive oxygen species. Collectively, these results suggested that trehalose can function as a novel activator of the p62-Keap1/Nrf2 pathway, in addition to inducing autophagy. ...
In addition, trehalose functions as an antioxidant though its underlying molecular mechanisms remain unclear. In this study, we showe …
Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction.
Lee HJ, et al. Cell Death Dis 2018 - Review. PMID 29907758 Free PMC article.
The mechanism underlying the neuroprotective effects of trehalose remains elusive. The prevailing hypothesis is that trehalose protects neurons by inducing autophagy, thereby clearing protein aggregates. ...Furthermore, a recent study with a thorough examination of autophagy flux showed that trehalose interfered with the flux from autophagosome to autolysosome, raising controversy on the direct effects of trehalose on autophagy. ...
The mechanism underlying the neuroprotective effects of trehalose remains elusive. The prevailing hypothesis is that trehalose
Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis
Sergin I, et al. Nat Commun 2017. PMID 28589926 Free PMC article.
In order to harness this degradative response therapeutically, we also describe a natural sugar called trehalose as an inducer of macrophage autophagy-lysosomal biogenesis and show trehalose's ability to recapitulate the atheroprotective properties of macrophage TFEB overexpression. ...
In order to harness this degradative response therapeutically, we also describe a natural sugar called trehalose as an inducer of mac …
TFEB-dependent induction of thermogenesis by the hepatocyte SLC2A inhibitor trehalose.
Zhang Y, et al. Autophagy 2018. PMID 29996716 Free PMC article.
However, although every major demonstration of trehalose action invokes activating autophagic flux as its primary function, the mechanism of action of trehalose in whole-body energy metabolism remains poorly defined. ...In contrast, we found that trehalose action on thermogenesis was independent of LEP (leptin) and the autophagy pathway, as there was robust thermogenic induction in trehalose-treated ob/ob, Becn1, Atg16l1, and Epg5 mutant mice. ...
However, although every major demonstration of trehalose action invokes activating autophagic flux as its primary function, the mecha …
TFEB and trehalose drive the macrophage autophagy-lysosome system to protect against atherosclerosis.
Evans TD, et al. Autophagy 2018. PMID 29394113 Free PMC article.
Conversely, in a recent study we hypothesized that enhancing the macrophage autophagy-lysosomal system through genetic or pharmacological means could protect against atherosclerosis. ...Further, we characterized the disaccharide trehalose as a novel inducer of TFEB with similar atheroprotective effects. Overall, these findings mechanistically interrogate the importance and therapeutic promise of a functional autophagy-lysosome degradation system in plaque macrophage biology....
Conversely, in a recent study we hypothesized that enhancing the macrophage autophagy-lysosomal system through genetic or pharmacological
mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases
Palmieri M, et al. Nat Commun 2017. PMID 28165011 Free PMC article.
Here we identify a pharmacologically actionable pathway that controls cellular clearance via Akt modulation of transcription factor EB (TFEB), a master regulator of lysosomal pathways. ...The autophagy enhancer trehalose activates TFEB by diminishing Akt activity. Administration of trehalose to a mouse model of Batten disease, a prototypical neurodegenerative disease presenting with intralysosomal storage, enhances clearance of proteolipid aggregates, reduces neuropathology and prolongs survival of diseased mice. ...
Here we identify a pharmacologically actionable pathway that controls cellular clearance via Akt modulation of transcription factor E …
Degradation-resistant trehalose analogues block utilization of trehalose by hypervirulent Clostridioides difficile.
Danielson ND, et al. Chem Commun (Camb) 2019. PMID 30968891 Free PMC article.
Furthermore, we demonstrate that trehalose analogues, but not the known trehalase inhibitor validamycin A, inhibit native trehalose utilization by hypervirulent C. difficile. Thus, degradation-resistant trehalose analogues are valuable as trehalase inhibitors and as surrogates for or co-additives with trehalose in applications where enzymatic breakdown is a concern....
Furthermore, we demonstrate that trehalose analogues, but not the known trehalase inhibitor validamycin A, inhibit native trehalos
Trehalose restores functional autophagy suppressed by high glucose.
Xu C, et al. Reprod Toxicol 2019. PMID 30769031
To determine whether trehalose directly induces autophagy, FITC-labeled trehalose was used for tracing its presence in autophagosome complexes. ...Trehalose effectively reversed high glucose-suppressed autophagy and reduced p62 protein expression. Trehalose abolished the disruption of autophagosome complexes under high glucose conditions in vitro and maternal diabetes in vivo. ...
To determine whether trehalose directly induces autophagy, FITC-labeled trehalose was used for tracing its presence in autopha …
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